Results 51 to 60 of about 18,519 (218)

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission [PDF]

, 2020
Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear.
Abel, Steven, Batugedara, Gayani, Bottrill, Andrew R., Boucher, Matthew, Brady, Declan, Daniel, Emilie, Freville, Aline, Gupta, Dinesh, Holder, Anthony A., Hollin, Thomas, Le Roch, Karine G., Lu, Xueqing Maggie, Pandey, Rajan, Rea, Edward, Stanway, Rebecca R., Tewari, Rita, Wall, Richard J., Wheatley, Sally, Zeeshan, Mohammad   +18 more
core   +3 more sources

Gametocyte carriage in Plasmodium falciparum-infected travellers [PDF]

Malaria Journal, 2013
Abstract Background Gametocytes are the sexual stage of Plasmodium parasites. The determinants of gametocyte carriage have been studied extensively in endemic areas, but have rarely been explored in travellers with malaria.
Roberts, CH, Armstrong, M, Zatyka, E, Boadi, S, Warren, S, Chiodini, PL, Sutherland, CJ, Doherty, T   +7 more
openaire   +6 more sources

Mesenchymal stem cells of the bone marrow raise infectivity of Plasmodium falciparum gametocytes

mBio, 2023
Plasmodium falciparum is a parasite that causes the deadly human disease, malaria, and exhibits a complex life cycle in human and mosquito hosts. In the sexual stages of the parasite, gametocytes mature in the human body and propagate malaria when they ...
Ragavan Varadharajan Suresh, Bingbing Deng, Yonas Gebremicale, Kyle Roche, Kazutoyo Miura, Carole Long   +5 more
doaj   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.

, 2001
Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by reducing gametocyte infectivity would be an additional benefit.
Targett, G, Drakeley, C, Jawara, M, von Seidlein, L, Coleman, R, Deen, J, Pinder, M, Doherty, T, Sutherland, C, Walraven, G, Milligan, P   +10 more
core   +1 more source

Unraveling Occurrence Patterns and Diversity of Avian Malaria Parasites in Iberian Obligate and Facultative Scavenger Birds

Integrative Zoology, EarlyView.
Low overall haemosporidian occurrence (3.4%; 13/383). Unexpected high lineage diversity (10 new host–parasite interactions). Novel Leucocytozoon lineage (GYPBAR01) in all European vultures except the griffon vulture. Plasmodium relictum (lineage SGS1) in adult red kites.
Pilar Oliva‐Vidal, Jaime Muriel, Alfonso Marzal, Grethell Mabel López del Aguila, José María Martínez, Antoni Margalida   +5 more
wiley   +1 more source

NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.

, 2010
We characterized vaccine-induced cellular responses to rabies virus in naive adult volunteers. Contrary to current paradigms, we observed potent and prolonged in vitro NK cell cytokine production and degranulation responses after restimulation of PBMCs ...
Behrens, Ron H, Fooks, Anthony R, Horowitz, Amir, Okell, Lucy, Riley, Eleanor M   +4 more
core   +1 more source

Molecular evidence of incipient speciation within Anopheles gambiae s.s. in West Africa [PDF]

, 2001
We karyotyped and identified by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis Anopheles gambiae s.s. samples collected in several African countries. The data show the existence of two non-panmictic molecular forms,
Akogbeto, M, Coluzzi, M, della Torre, A, Dossou-Yovo, J, Fanello, C, Favia, G, Petrarca, V   +6 more
core   +1 more source

Genomic Content in Avian Haemosporidian Parasites Suggests Co‐Regulation of Apicoplast and Mitochondrial Nucleoids

Integrative Zoology, EarlyView.
Apicoplast genomic content and mitochondrial genomic content were found to be strongly correlated (rho = 0.93) for infections going from low to high. Apicoplast and mitochondrial genomic content were deemed as more predictive factors of parasitemia for different infection intensities.
Gaia Porporato, Peter Pibaque, Alanis Cruz Flores, Simone Cescutti, Nayden Chakarov   +4 more
wiley   +1 more source

Antibodies to PfsEGXP, an Early Gametocyte-Enriched Phosphoprotein, Predict Decreased Plasmodium falciparum Gametocyte Density in Humans [PDF]

The Journal of Infectious Diseases, 2018
Antigametocyte-specific immune responses may regulate Plasmodium falciparum gametocyte density, providing the rationale for pursuing transmission-blocking vaccines (TBVs) that target gametocytes in the human host.To identify novel antigametocyte TBV antigens, we interrogated the gametocyte proteome with our whole proteome differential screening method ...
Christian P Nixon, Christina E Nixon, Ian C Michelow, Rayna A Silva-Viera, Bonnie Colantuono, Aisha S Obeidallah, Ambrish Jha, Dominique Dockery, Dipak Raj, Sangshin Park, Patrick E Duffy, Jonathan D Kurtis   +11 more
openaire   +2 more sources