Results 71 to 80 of about 18,519 (218)

Improving statistical inference on pathogen densities estimated by quantitative molecular methods: malaria gametocytaemia as a case study [PDF]

, 2015
BACKGROUND: Quantitative molecular methods (QMMs) such as quantitative real-time polymerase chain reaction (q-PCR), reverse-transcriptase PCR (qRT-PCR) and quantitative nucleic acid sequence-based amplification (QT-NASBA) are increasingly used to ...
A Gelman, André Lin Ouédraogo, B Hoadley, C Eisenhart, C Fraser, C Osborne, CE McCulloch, Cornelus Hermsen, D Lunn, DJ Lunn, DJ Spiegelhalter, DL Massart, EC Fieller, F Ferre, FA Graybill, G Marsaglia, GK Shulka, HG Niesters, HS Mubarak El, J Jiang, J Wain, JF Cohen, JH McCulloch, JM Ruijter, JN Miller, JO Beer De, JS Murray, JS Yuan, K Danzer, K Khairnar, KK Lai, LC Okell, LJ Naszódi, M Plummer, M Sivaganesan, M Woodhead, Martin Walker, María-Gloria Basáñez, NM Ferguson, P Schneider, P Schneider, P Vankeerberghen, PF Mens, R Wampfler, S Nadarajah, SA Bustin, SA Bustin, SA Fiscus, T Nolan, T Ponnudurai, TD Schmittgen, Teun Bousema, Thomas S Churcher, TS Churcher, World Health Organization, Y Karlen, YW Tang   +56 more
core   +4 more sources

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Declining Burden of Malaria Over two Decades in a Rural Community of Muheza District, North-Eastern Tanzania. [PDF]

, 2013
The recently reported declining burden of malaria in some African countries has been attributed to scaling-up of different interventions although in some areas, these changes started before implementation of major interventions.
A Bhattarai, AC Ghani, AM Ronn, AS Rutta, BA Okech, BL Sharp, BP Mmbando, Bruno P Mmbando, C Karema, C Lengeler, Deus S Ishengoma, DS Ishengoma, DW Meyrowitsch, E Chizema-Kawesha, EA Okiro, EA Okiro, FO ter Kuile, G Mtove, G O'Connor, H Reyburn, HD Teklehaimanot, I Kleinschmidt, I Kleinschmidt, Ib C Bygbjerg, J Mufunda, J Picard, JC Beier, JP Lusingu, KI Barnes, M Alifrangis, M Lemnge, M Otten, Martha M Lemnge, Method D Segeja, MH Craig, MH Craig, Michael Alifrangis, Ministry of Health, Ministry of Health, MK Bouyou-Akotet, MM Lemnge, MM Lemnge, MS Hsiang, MW Aregawi, National Malaria Control Programme, P Chanda, P Winskill, PH Jakobsen, PM Graves, PM Nyarango, R Maharaj, RJ Manuel, RW Steketee, SJ Ceesay, SJ Ceesay, SM Magesa, T Bousema, T Jelinek, T Jelinek, VA Kilimali, WHO, WHO, WHO, WP O'Meara, WP O'Meara, YA Derua   +65 more
core   +2 more sources

Scientists' Warning on the Rapid Evolution of Parasites in the Anthropocene

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT Human activities are changing the natural world at an accelerating pace, and as a consequence exerting novel and often strong selection pressures on living organisms. For species with traits conferring huge inherent evolutionary potential, like parasites, the outcome may be rapid adaptive responses spanning multiple phenotypic traits. The rise
Robert Poulin, Jerusha Bennett, Isabel Blasco‐Costa, Daniela de Angeli Dutra, Jean‐François Doherty, Eddy Dowle, Antoine Filion, Brian L. Fredensborg, Ryota Hasegawa, Kristin K. Herrmann, Devon B. Keeney, Anson V. Koehler, Janet Koprivnikar, Clément Lagrue, Henry S. Lane, Tommy L. F. Leung, Chen‐Hua Li, Colin D. MacLeod, Kim N. Mouritsen, Chris N. Niebuhr, Katie O'Dwyer, Eunji Park, Rachel A. Paterson, Bronwen Presswell, Haseeb S. Randhawa, Brandon Ruehle, Amandine Sabadel, Priscila M. Salloum, David W. Thieltges, Frédéric Thomas, Christian Selbach   +30 more
wiley   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Towards clinical development of a Pfs48/45-based transmission blocking malaria vaccine

Expert Review of Vaccines, 2017
Introduction: Malaria is a devastating vector-borne disease caused by the Plasmodium parasite, resulting in almost 0.5 million casualties per year. The parasite has a complex life-cycle that includes asexual replication in human red blood cells, causing ...
Michael Theisen, Matthijs M. Jore, Robert Sauerwein   +2 more
doaj   +1 more source

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. [PDF]

, 2006
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.
Balkan, S, Checchi, F, Durand, R, Grandesso, F, Guthmann, J P, Hagerman, A, Kamara, S, Lam, E, Scollo, G   +8 more
core   +2 more sources

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, Volume 31, Issue 3, Page 254-273, March 2026.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation

BMC Biology, 2023
Background The protozoan malaria parasite Plasmodium falciparum has a complex life cycle during which it needs to differentiate into multiple morphologically distinct life forms.
Myriam D. Jeninga, Jingyi Tang, Shamista A. Selvarajah, Alexander G. Maier, Michael F. Duffy, Michaela Petter   +5 more
doaj   +1 more source

The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation [PDF]

, 2012
<b>Background</b> Malaria parasites undergo, in the vertebrate host, a developmental switch from asexual replication to sexual differentiation leading to the formation of gametocytes, the only form able to survive in the mosquito vector ...
AG Maier, AM Talman, Andrew Tomlins, C Aurrecoechea, Christian Doerig, CJ Tonkin, EK De Silva, F Silvestrini, J Miao, JA Braks, KG Le Roch, L O’Regan, L Reininger, L Reininger, L Reininger, LM Quarmby, Luc Reininger, M Dyer, MC Bruce, Miguel Garcia, N Hall, P Alano, R Carter, RE Sinden, S Eksi, S Singh, SM Khan, Sylke Müller   +27 more
core   +6 more sources