Results 81 to 90 of about 18,519 (218)

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite

Traffic, Volume 27, Issue 1, March 2026.
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Jun Miao, Amuza Byaruhanga Lucky, Gang Ning, Xian Xia, Xiaoying Liang, Faiza Siddiqui, Hui Min, Chengqi Wang, Xiaolian Li, Z. Hong Zhou, Liwang Cui   +10 more
wiley   +1 more source

Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection

mBio, 2018
Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide. Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation, and it is often assumed that accumulation/sequestration in tissues is not an ...
Nicanor Obaldia, Elamaran Meibalan, Juliana M. Sa, Siyuan Ma, Martha A. Clark, Pedro Mejia, Roberto R. Moraes Barros, William Otero, Marcelo U. Ferreira, James R. Mitchell, Danny A. Milner, Curtis Huttenhower, Dyann F. Wirth, Manoj T. Duraisingh, Thomas E. Wellems, Matthias Marti   +15 more
doaj   +1 more source

Sulfadoxine-pyrimethamine–based combinations for malaria : a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi [PDF]

, 2008
Background: In Malawi, there has been a return of Plasmodium falciparum sensitivity to chloroquine (CQ) since sulfadoxinepyrimethamine (SP) replaced CQ as first line treatment for uncomplicated malaria.
David J. Bell, Suzgo K. Nyirongo, Mavuto Mukaka, Ed E. Zijlstra, Christopher V. Plowe, Malcolm E. Molyneux, Steve A. Ward, Peter A. Winstanley, Aric Gregson, CV Plowe, MK Laufer, P Olumese, CO Obonyo, P Brasseur, AF Gasasira, CS Hatton, KA Neftel, P Olliaro, AA Djimde, JG Kublin, CV Plowe, A Cattamanchi, JG Kublin, TO Abuya, SR Hawley, G Dorsey, CE Rwagacondo, WM Watkins, CT Happi, GS Humphreys, SL Nsobya, I Zongo, C Dokomajilar, C Sisowath, MT Duraisingh, AP Alker, PA Phillips-Howard, D Douer, R Carr, EG Rhodes, ME Ellis   +40 more
core   +7 more sources

Critical Steps of Plasmodium falciparum Ookinete Maturation [PDF]

, 2020
The egress and fertilization of Plasmodium gametes and development of a motile ookinete are the first crucial steps that mediate the successful transmission of the malaria parasites from humans to the Anopheles vector. However, limited information exists
Alano, P., Costa, G., Levashina, E., Siciliano, G., Suárez-Cortés, P., Valleriani, A.   +5 more
core   +1 more source

Benzoxaboroles Are Inhibitors of the η‐Class Carbonic Anhydrase From Plasmodium falciparum

Archiv der Pharmazie, Volume 359, Issue 2, February 2026.
Benzoxaborole‐based inhibitors demonstrate potent, low‐micromolar inhibition of the essential malaria target PfaCA and are effective in vitro suppression of P. falciparum. Molecular docking confirms target engagement via zinc coordination, establishing this chemotype as a promising scaffold for the development of next‐generation antimalarials ...
Alessandro Bonardi, Sharon Wein, Muhamad Mustafa, Rachel Cerdan, Viviana de Luca, Clemente Capasso, Paola Gratteri, Claudiu T. Supuran, Alessio Nocentini, Jean‐Yves Winum   +9 more
wiley   +1 more source

Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology [PDF]

, 2014
One of the critical gaps in malaria transmission biology and surveillance is our lack of knowledge about Plasmodium falciparum gametocyte biology, especially sexual dimorphic development and how sex ratios that may influence transmission from the human ...
Dinglasan, R. R., Goldowitz, I., Graham, D. R., King, J. G., Marti, M., Mathias, D. K., Moss, E., Pastrana-Mena, R., Tao, D., Tripathi, A., Ubaida-Mohien, C.   +10 more
core   +1 more source

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 589-605, February 2026.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates

BMC Genomics, 2017
Background The clinical symptoms of malaria are caused by the asexual replication of Plasmodium parasites in the blood of the vertebrate host. To spread to new hosts, however, the malaria parasite must differentiate into sexual forms, termed gametocytes,
Lee M. Yeoh, Christopher D. Goodman, Vanessa Mollard, Geoffrey I. McFadden, Stuart A. Ralph   +4 more
doaj   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, Volume 301, Issue 2, Page 122-150, February 2026.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Addressing the challenge of neonatal mortality.

, 2013
Reducing neonatal mortality remains a challenge with an estimated 3.0 million neonatal deaths in 2011, three-quarters of these in sub-Saharan Africa and Southern Asia.
Blencowe, H, Cousens, S
core   +1 more source