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2014
Gametes and their precursors, the gametocytes, are the very special cell types that Plasmodium developed in the course of evolution to accomplish such key steps in its life cycle and are the subject of this chapter. In the main, cellular and molecular aspects of gametocyte and gamete formation will be covered here.
Pietro Alano, Oliver Billker
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Gametes and their precursors, the gametocytes, are the very special cell types that Plasmodium developed in the course of evolution to accomplish such key steps in its life cycle and are the subject of this chapter. In the main, cellular and molecular aspects of gametocyte and gamete formation will be covered here.
Pietro Alano, Oliver Billker
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Gametogenesis in culture by gametocytes of Plasmodium falciparum
Nature, 1977CONTINUOUS culture of human malaria parasites, Plasmodium falciparum, in human red blood cells was first reported by Trager and Jensen1 and subsequently by Haynes and co-workers2. The culture system described by Trager and Jensen supports the asexual multiplication of P.
R, Carter, R F, Beach
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The Fine Structure of the Gametocytes of an Adeleine Haemogregarine
The Journal of Protozoology, 1967SYNOPSIS. Gametocytes of an unidentified haemogregarine (Sporozoa, Telosporea, Coccidia, Eucoccida, Adeleina, Haemogregarinicae) from the frog Rana montezumae were examined by light and electron microscopy. The fully‐grown gametocytes lay in a vacuole in the erythrocyte, surrounded by a sheath which was probably of parasitic origin.
J R, Baker, R, Lainson
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A Loss of Gametocytes in Plasmodium elongatum
The Journal of Parasitology, 1947The following study grew out of work on the susceptibility of various species of mosquitoes to the avian malarial parasite, Plasmodium elongatum, and its transmission through the mosquito to the canary and the duck. A review of the literature revealed the following references to the sexual forms. P. elongatum was named after its gametocyte (Huff, 1930)
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The Optimal Production of Gametocytes byPlasmodium falciparum
Journal of Theoretical Biology, 1998We use a simple model of the blood-stage infection dynamics of the malaria parasite Plasmodium falciparum to consider the adaptive significance of different rates of conversion from its pathogenic, asexual stages to its transmissible, sexual forms. We find that maximize transmissivity in single-strain infections are generally greater than the highest ...
F E, McKenzie, W H, Bossert
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Observations on the infectiousness of gametocytes in hyperendemic malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1953Abstract 1. (1) There is a correlation between the probability of a mosquito's becoming infected and the gametocyte density of the carrier, when densities are broadly grouped. 2. (2) A small series of experiments in the hyperendemic zone of S. W. Nigeria are reported in which A.
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Gene expression in Plasmodium: from gametocytes to sporozoites
International Journal for Parasitology, 2004Completion of the complex developmental program of Plasmodium in the mosquito is essential for parasite transmission, yet this part of its life cycle is still poorly understood. In recent years, considerable progress has been made in the identification and characterization of genes expressed during parasite development in the mosquito.
C K, Moreira +2 more
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Identification of telomerase activity in gametocytes of Plasmodium falciparum
Biochemical and Biophysical Research Communications, 2003Telomerase, a specialized cellular reverse transcriptase, compensates the chromosome shortening during the replication of most eukaryotic cells and contributes to cellular immortalization in cell culture (in vitro) and cancerous cell (in vivo). In the present study, the telomerase activity in the gametocytes of Plasmodium falciparum was investigated ...
Dipak Kumar, Raj +3 more
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Eradication of Gametocytes To Prevent Introduction of Falciparum Malaria
JAMA: The Journal of the American Medical Association, 1971To the Editor:— The recent report of a case ofPlasmodium falciparummalaria by Berman and Holmes (215:291, 1971) notes the persistence of gametocytemia following therapy with chloroquine and advocates the use of primaquine to eradicate gametocytes for the primary purpose of preventing the introduction (through mosquitoes) of falciparum malaria into the
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Targeting Plasmodium falciparum gametocytes
2015Drugs that are active against gametocytes, the stages of the malaria parasite responsible for transmission, are recognized as key tools required for the global elimination of malaria. As the majority of drugs currently used to treat clinical malaria target asexual intra-erythrocytic parasites most have limited inhibitory effects on gametocytes.
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