Results 21 to 30 of about 18,519 (218)
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionRecent evidence suggests that the bone marrow (BM) plays a key role in the diffusion of P. falciparum malaria by providing a “niche” for the maturation of the parasite gametocytes, responsible for human-to-mosquito transmission.
Samantha Donsante +11 more
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Cell Reports, 2019 Summary: Plasmodium falciparum gametocytes infect mosquitoes and are responsible for malaria transmission. New interventions that block transmission could accelerate malaria elimination. Gametocytes develop within erythrocytes and activate protein export
Charlie Jennison +8 more
doaj +1 more source
Detection of Plasmodium falciparum male and female gametocytes and determination of parasite sex ratio in human endemic populations by novel, cheap and robust RTqPCR assays [PDF]
, 2017 The presence of Plasmodium falciparum gametocytes in peripheral blood is essential for human to mosquito parasite transmission. The detection of submicroscopic infections with gametocytes and the estimation of the gametocyte sex ratio are crucial to ...
Alano, Pietro +8 more
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Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions? [PDF]
, 2012 A recent meta-analysis of mosquito feeding assays to determine the Plasmodium falciparum transmission potential of naturally infected gametocyte carriers highlighted considerable variation in transmission efficiency between assay methodologies and ...
Bousema, Teun +3 more
core +5 more sources
mSphere, 2020 We developed a flow-cytometry-based method to separate and collect cocultured male and female Plasmodium falciparum gametocytes responsible for malaria transmission. The purity of the collected cells was estimated at >97% using flow cytometry, and sorted
Melanie C. Ridgway +3 more
doaj +1 more source
mSphere, 2018 Sexual reproduction is an obligate step in the Plasmodium falciparum life cycle, with mature gametocytes being the only form of the parasite capable of human-to-mosquito transmission.
Katelyn A. Walzer +3 more
doaj +1 more source
Malaria Journal, 2012 Background Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear. Methods The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow ...
Farfour Eric +4 more
doaj +1 more source
Investigating the antiparasitic potential of the marine sesquiterpene avarone, its reduced form avarol, and the novel semisynthetic thiazinoquinone analogue thiazoavarone [PDF]
, 2020 The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal
AIELLO, ANNA +13 more
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Revisiting gametocyte biology in malaria parasites [PDF]
FEMS Microbiology Reviews, 2019 ABSTRACT Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito vector. They are present at low levels in blood circulation and significant knowledge gaps exist in their biology. Recent reductions in the global malaria burden have brought the possibility of elimination and eradication, with renewed ...
Ngotho, Priscilla +5 more
openaire +2 more sources
Plasticity in transmission strategies of the malaria parasite, Plasmodium chabaudi : environmental and genetic effects [PDF]
, 2012 Parasites may alter their behaviour to cope with changes in the within-host environment. In particular, investment in transmission may alter in response to the availability of parasite resources or host immune responses.
Cameron, Angus +4 more
core +1 more source