Results 21 to 30 of about 803 (130)

Revisiting gametocyte biology in malaria parasites [PDF]

FEMS Microbiology Reviews, 2019
ABSTRACT Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito vector. They are present at low levels in blood circulation and significant knowledge gaps exist in their biology. Recent reductions in the global malaria burden have brought the possibility of elimination and eradication, with renewed ...
Ngotho, Priscilla, Blancke Soares, Alexandra, Hentzschel, Franziska, Achcar, Fiona, Bertuccini, Lucia, Marti, Matthias   +5 more
openaire   +2 more sources

Real-time PCR assays for detection and quantification of early P. falciparum gametocyte stages

Scientific Reports, 2021
The use of quantitative qRT-PCR assays for detection and quantification of late gametocyte stages has revealed the high transmission capacity of the human malaria parasite, Plasmodium falciparum. To understand how the parasite adjusts its transmission in
Amal A. H. Gadalla, Giulia Siciliano, Ryan Farid, Pietro Alano, Lisa Ranford-Cartwright, James S. McCarthy, Joanne Thompson, Hamza A Babiker   +7 more
doaj   +1 more source

Immune Responses to the Sexual Stages of Plasmodium falciparum Parasites

Frontiers in Immunology, 2019
Malaria infections remain a serious global health problem in the world, particularly among children and pregnant women in Sub-Saharan Africa. Moreover, malaria control and elimination is hampered by rapid development of resistance by the parasite and the
Jonas A. Kengne-Ouafo, Colin J. Sutherland, Fred N. Binka, Gordon A. Awandare, Britta C. Urban, Bismarck Dinko   +5 more
doaj   +1 more source

Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation

BMC Biology, 2023
Background The protozoan malaria parasite Plasmodium falciparum has a complex life cycle during which it needs to differentiate into multiple morphologically distinct life forms.
Myriam D. Jeninga, Jingyi Tang, Shamista A. Selvarajah, Alexander G. Maier, Michael F. Duffy, Michaela Petter   +5 more
doaj   +1 more source

Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies

Microorganisms, 2023
Malaria elimination may never succeed without the implementation of transmission-blocking strategies. The transmission of Plasmodium spp. parasites from the human host to the mosquito vector depends on circulating gametocytes in the peripheral blood of ...
Dinkorma T. Ouologuem, Antoine Dara, Aminatou Kone, Amed Ouattara, Abdoulaye A. Djimde   +4 more
doaj   +1 more source

Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia

Memorias do Instituto Oswaldo Cruz, 2002
The effect of antimalarials on gametocytes can influence transmission and the spread of drug resistance. In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with ...
Lyda Osorio, Beatriz E Ferro, Carmen M Castillo   +2 more
doaj   +1 more source

Mesenchymal stem cells of the bone marrow raise infectivity of Plasmodium falciparum gametocytes

mBio, 2023
Plasmodium falciparum is a parasite that causes the deadly human disease, malaria, and exhibits a complex life cycle in human and mosquito hosts. In the sexual stages of the parasite, gametocytes mature in the human body and propagate malaria when they ...
Ragavan Varadharajan Suresh, Bingbing Deng, Yonas Gebremicale, Kyle Roche, Kazutoyo Miura, Carole Long   +5 more
doaj   +1 more source

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

eLife, 2018
Background: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is ...
Isaie J Reuling, Lisanne A van de Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Quirijn de Mast, André J van der Ven, Karen Ivinson, Cornelus C Hermsen, Sake de Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W Sauerwein, Teun Bousema   +20 more
doaj   +1 more source

The role of cytokines in Plasmodium vivax malaria

Memorias do Instituto Oswaldo Cruz, 1992
The cytokine tumor necrosis factor and other as yet unidentified factor(s) which together mediate the killing of intraerythrocytic malaria parasites are transiently elevated in sera during paroxysms in human Plasmodium vivax infections in non-immunes ...
K. N. Mendis, R. Carter
doaj   +1 more source

Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes

Frontiers in Cellular and Infection Microbiology, 2022
Despite significant developments towards malaria reduction, parasite transmission in the common context of HIV-1 co-infection and treatment for one or both infections has not been fully characterized.
Ashleigh Roberds, Carolyne Kifude, Janet Oyieko, Stephen Ocholla, James Mutunga, James Mutunga, David Oullo, Charles Waga, Zhaozhang Li, Shirley Luckhart, V. Ann Stewart   +10 more
doaj   +1 more source