Results 81 to 90 of about 9,642 (218)

Specific expression and export of the Plasmodium falciparum Gametocyte EXported Protein-5 marks the gametocyte ring stage [PDF]

Malaria Journal, 2015
Plasmodium falciparum sexual development plays a fundamental role in the transmission and spread of malaria. The ability to generate gametocytes can be lost during culture in vitro, often associated with the loss of a subtelomeric region of chromosome 9. Gametocytogenesis starts with erythrocyte invasion by a sexually committed merozoite, but the first
Tiburcio, M, Dixon, MWA, Looker, O, Younis, SY, Tilley, L, Alano, P   +5 more
openaire   +3 more sources

Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate. [PDF]

, 2007
BACKGROUND: P. falciparum gametocytes may persist after treatment with sulphadoxine-pyrimethamine (SP) plus artesunate (AS) and contribute considerably to malaria transmission.
Alifrangis, M., Mosha, F., Anders Enevold, Bousema, Teun, Arnold Ndaro, Shekalaghe Seif, Shekalaghe, Seif, van Meegeren Monique, Sauerwein Robert, Sauerwein, R.W., Seif Shekalaghe, Gosling Roly, Shekalaghe, S., Ndaro, A., Frank Mosha, Enevold Anders, Drakeley, Chris, Gosling, R., Chris Drakeley, Monique van Meegeren, Teun Bousema, Meegeren, M. van, Robert Sauerwein, van Meegeren, Monique, Enevold, A., Bousema, T., Sauerwein, R., Mosha, Frank, Alifrangis Michael, Drakeley Chris, Bousema Teun, Ndaro Arnold, Gosling, Roly, Drakeley, C., Enevold, Anders, Michael Alifrangis, Alifrangis, Michael, Sauerwein, Robert, Mosha Frank, Meegeren, M.E.R. van, Roly Gosling, Ndaro, Arnold   +41 more
core   +2 more sources

Multivariate predictors of gametocyte positivity and density.

, 2021
Multivariate predictors of gametocyte positivity and density.
Ingrid Felger (92160), Andrew W. Darcy (11349367), Wang Nguitragool (546889), Marcus Lacerda (742724), Wuelton Monteiro (752733), Quique Bassat (89288), Maria Ome-Kaius (735581), Eline Kattenberg (7338002), Jetsumon Sattabongkot (82977), Ivo Mueller (46609), Leanne J. Robinson (8582340), Anne Cristine Gomes de Almeida (11349364), Thomas Obadia (5662633), Patricia Rarau (137896), James Kazura (426081), Andreea Waltmann (742598), Cristian Koepfli (191306), Lyndes Wini (4801131), Andrea Kuehn (621792)   +18 more
core   +1 more source

Quantitative and Clinical Pharmacology Perspectives on Next‐Generation Malaria Prevention Using Vaccines and Long‐Acting Monoclonal Antibodies

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Malaria remains a significant global health burden, particularly among pediatric populations in endemic regions. Recent advances in preventive interventions highlight the complementary roles of vaccines and long‐acting monoclonal antibodies (mAbs) in reducing infection risk.
Sabiha R. Mim, Leonardo C. Xavier, Francine J. Azeredo, Sihem Ait‐Oudhia   +3 more
wiley   +1 more source

Antibodies to PfsEGXP, an Early Gametocyte-Enriched Phosphoprotein, Predict Decreased Plasmodium falciparum Gametocyte Density in Humans [PDF]

The Journal of Infectious Diseases, 2018
Antigametocyte-specific immune responses may regulate Plasmodium falciparum gametocyte density, providing the rationale for pursuing transmission-blocking vaccines (TBVs) that target gametocytes in the human host.To identify novel antigametocyte TBV antigens, we interrogated the gametocyte proteome with our whole proteome differential screening method ...
Christian P Nixon, Christina E Nixon, Ian C Michelow, Rayna A Silva-Viera, Bonnie Colantuono, Aisha S Obeidallah, Ambrish Jha, Dominique Dockery, Dipak Raj, Sangshin Park, Patrick E Duffy, Jonathan D Kurtis   +11 more
openaire   +2 more sources

Plasmodium falciparum gametocyte dynamics after pyronaridine–artesunate or artemether–lumefantrine treatment

Malaria Journal, 2018
Background Artemisinin-based combinations differ in their impact on gametocyte prevalence and density. This study assessed female and male gametocyte dynamics after treating children with uncomplicated Plasmodium falciparum malaria with either ...
Johanna M. Roth, Patrick Sawa, George Omweri, Victor Osoti, Nicodemus Makio, John Bradley, Teun Bousema, Henk D. F. H. Schallig, Pètra F. Mens   +8 more
doaj   +1 more source

Heritability of the human infectious reservoir of malaria parasites. [PDF]

PLoS ONE, 2010
BackgroundStudies on human genetic factors associated with malaria have hitherto concentrated on their role in susceptibility to and protection from disease. In contrast, virtually no attention has been paid to the role of human genetics in eliciting the
Yaye Ramatoulaye Lawaly, Anavaj Sakuntabhai, Laurence Marrama, Lassana Konate, Waraphon Phimpraphi, Cheikh Sokhna, Adama Tall, Fatoumata Diène Sarr, Chayanon Peerapittayamongkol, Chalisa Louicharoen, Bradley S Schneider, Anaïs Levescot, Arthur Talman, Isabelle Casademont, Didier Menard, Jean-François Trape, Christophe Rogier, Jaranit Kaewkunwal, Thanyachai Sura, Issarang Nuchprayoon, Frederic Ariey, Laurence Baril, Pratap Singhasivanon, Odile Mercereau-Puijalon, Rick Paul   +24 more
doaj   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Plasmodium falciparum Gametocyte-Specific Antibody Profiling Reveals Boosting through Natural Infection and Identifies Potential Markers of Gametocyte Exposure [PDF]

, 2015
Malaria elimination efforts would benefit from vaccines that block transmission of Plasmodium falciparum gametocytes from humans to mosquitoes. A clear understanding of gametocyte-specific antibody responses in exposed populations could help determine ...
Crompton, Peter D, Jeff Skinner, Philip L. Felgner, Michael Waisberg, Boubacar Traore, Williamson, Kim C, Felgner, Philip L, Traore, Boubacar, Kassoum Kayentao, Huang, Chiung-Yu, Kayentao, Kassoum, Ogobara K. Doumbo, Ongoiba, Aissata, Skinner, Jeff, Chiung-Yu Huang, Kim C. Williamson, Waisberg, Michael, Aissata Ongoiba, Peter D. Crompton, Doumbo, Ogobara K   +19 more
core   +1 more source

Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin

Cytoskeleton, Volume 83, Issue 7, Page 479-483, July 2026.
ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel, Friedrich Frischknecht, Matthias Marti   +2 more
wiley   +1 more source