Results 91 to 100 of about 13,563 (220)

Exploration of in Vivo Efficacy of Artemether-Lumefantrine Against Uncomplicated Plasmodium Falciparum Malaria in Under Fives in Tabora Region, Tanzania. [PDF]

, 2013
Tanzania adopted artemether-lumefantrine (AL) as first-line drug for uncomplicated malaria in 2006. Recently, there was an anecdotal report on high malaria recurrence rate following AL treatment in in the (urban and peri-urban), western part of Tanzania.
Hulser, Ruth, Joseph, Deokary, Kabanywanyi, Abdunoor M, Minzi, Omary Ms, Mugittu, Kefas, Premji, Zulfiqarali   +5 more
core   +3 more sources

Scientists' Warning on the Rapid Evolution of Parasites in the Anthropocene

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT Human activities are changing the natural world at an accelerating pace, and as a consequence exerting novel and often strong selection pressures on living organisms. For species with traits conferring huge inherent evolutionary potential, like parasites, the outcome may be rapid adaptive responses spanning multiple phenotypic traits. The rise
Robert Poulin, Jerusha Bennett, Isabel Blasco‐Costa, Daniela de Angeli Dutra, Jean‐François Doherty, Eddy Dowle, Antoine Filion, Brian L. Fredensborg, Ryota Hasegawa, Kristin K. Herrmann, Devon B. Keeney, Anson V. Koehler, Janet Koprivnikar, Clément Lagrue, Henry S. Lane, Tommy L. F. Leung, Chen‐Hua Li, Colin D. MacLeod, Kim N. Mouritsen, Chris N. Niebuhr, Katie O'Dwyer, Eunji Park, Rachel A. Paterson, Bronwen Presswell, Haseeb S. Randhawa, Brandon Ruehle, Amandine Sabadel, Priscila M. Salloum, David W. Thieltges, Frédéric Thomas, Christian Selbach   +30 more
wiley   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Host age and Plasmodium falciparum multiclonality are associated with gametocyte prevalence: a 1-year prospective cohort study

Malaria Journal, 2017
Background Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of the life cycle.
Yaw Adomako-Ankomah, Matthew S. Chenoweth, Aaron M. Tocker, Saibou Doumbia, Drissa Konate, Mory Doumbouya, Abdoul S. Keita, Jennifer M. Anderson, Rick M. Fairhurst, Mahamadou Diakite, Kazutoyo Miura, Carole A. Long   +11 more
doaj   +1 more source

Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination

, 2015
Antimalarial drugs are a powerful tool for malaria control and elimination. Artemisinin-based combination therapies (ACTs) can reduce transmission when widely distributed in a campaign setting.
Eckhoff, Philip, Gerardin, Jaline, Wenger, Edward A.   +2 more
core   +1 more source

Prospective evaluation of BDProbeTec strand displacement amplification (SDA) system for diagnosis of tuberculosis in non-respiratory and respiratory samples. [PDF]

, 2004
Nucleic acid amplification techniques (NAATs) have been demonstrated to make significant improvements in the diagnosis of tuberculosis (TB), particularly in the time to diagnosis and the diagnosis of smear-negative TB. The BD ProbeTec strand displacement
Billington, OJ, Gillespie, SH, Gosling, RD, Ling, CL, Lipman, MC, McHugh, TD, Patel, S, Pope, CF   +7 more
core   +2 more sources

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, Volume 31, Issue 3, Page 254-273, March 2026.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation [PDF]

, 2012
<b>Background</b> Malaria parasites undergo, in the vertebrate host, a developmental switch from asexual replication to sexual differentiation leading to the formation of gametocytes, the only form able to survive in the mosquito vector ...
AG Maier, AM Talman, Andrew Tomlins, C Aurrecoechea, Christian Doerig, CJ Tonkin, EK De Silva, F Silvestrini, J Miao, JA Braks, KG Le Roch, L O’Regan, L Reininger, L Reininger, L Reininger, LM Quarmby, Luc Reininger, M Dyer, MC Bruce, Miguel Garcia, N Hall, P Alano, R Carter, RE Sinden, S Eksi, S Singh, SM Khan, Sylke Müller   +27 more
core   +6 more sources

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite

Traffic, Volume 27, Issue 1, March 2026.
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Jun Miao, Amuza Byaruhanga Lucky, Gang Ning, Xian Xia, Xiaoying Liang, Faiza Siddiqui, Hui Min, Chengqi Wang, Xiaolian Li, Z. Hong Zhou, Liwang Cui   +10 more
wiley   +1 more source

Benzoxaboroles Are Inhibitors of the η‐Class Carbonic Anhydrase From Plasmodium falciparum

Archiv der Pharmazie, Volume 359, Issue 2, February 2026.
Benzoxaborole‐based inhibitors demonstrate potent, low‐micromolar inhibition of the essential malaria target PfaCA and are effective in vitro suppression of P. falciparum. Molecular docking confirms target engagement via zinc coordination, establishing this chemotype as a promising scaffold for the development of next‐generation antimalarials ...
Alessandro Bonardi, Sharon Wein, Muhamad Mustafa, Rachel Cerdan, Viviana de Luca, Clemente Capasso, Paola Gratteri, Claudiu T. Supuran, Alessio Nocentini, Jean‐Yves Winum   +9 more
wiley   +1 more source