Results 101 to 110 of about 13,563 (220)

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 589-605, February 2026.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Plasmodium falciparum gametocyte dynamics after pyronaridine–artesunate or artemether–lumefantrine treatment

Malaria Journal, 2018
Background Artemisinin-based combinations differ in their impact on gametocyte prevalence and density. This study assessed female and male gametocyte dynamics after treating children with uncomplicated Plasmodium falciparum malaria with either ...
Johanna M. Roth, Patrick Sawa, George Omweri, Victor Osoti, Nicodemus Makio, John Bradley, Teun Bousema, Henk D. F. H. Schallig, Pètra F. Mens   +8 more
doaj   +1 more source

Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission. [PDF]

PLoS ONE, 2009
BACKGROUND:Man to mosquito transmission of malaria depends on the presence of the sexual stage parasites, gametocytes, that often circulate at low densities.
André Lin Ouédraogo, Teun Bousema, Petra Schneider, Sake J de Vlas, Edith Ilboudo-Sanogo, Nadine Cuzin-Ouattara, Issa Nébié, Will Roeffen, Jan Peter Verhave, Adrian J F Luty, Robert Sauerwein   +10 more
doaj   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, Volume 301, Issue 2, Page 122-150, February 2026.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Probing Plasmodium falciparum sexual commitment at the single-cell level [PDF]

, 2018
Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure.
Birren, Bruce W., Brancucci, Nicolas M.B., De Niz, Mariana, Marti, Matthias, Neafsey, Daniel E., Ravel, Deepali, Sollelis, Lauriane, Straub, Timothy J., Voss, Till S.   +8 more
core   +4 more sources

Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology

Journal of Microscopy, Volume 301, Issue 2, Page 280-329, February 2026.
Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz, Sara Silva Pereira, David Kirchenbuechler, Leandro Lemgruber, Constadina Arvanitis   +4 more
wiley   +1 more source

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

eLife
It is currently unknown whether all Plasmodium falciparum-infected mosquitoes are equally infectious. We assessed sporogonic development using cultured gametocytes in the Netherlands and naturally circulating strains in Burkina Faso.
Chiara Andolina, Wouter Graumans, Moussa Guelbeogo, Geert-Jan van Gemert, Jordache Ramijth, Soré Harouna, Zongo Soumanaba, Rianne Stoter, Marga Vegte-Bolmer, Martina Pangos, Photini Sinnis, Katharine Collins, Sarah G Staedke, Alfred B Tiono, Chris Drakeley, Kjerstin Lanke, Teun Bousema   +16 more
doaj   +1 more source

Peripheral Blood Erythrophagocytosis in Plasmodium falciparum Malaria

American Journal of Hematology, Volume 101, Issue 6, Page 1268-1268, June 2026.
Teresa Almeida, Cristina Avelar Ferreira
wiley   +1 more source

Cellular Hallmarks From Volume Electron Microscopy Reveal Developmental Progression of Plasmodium Ookinetes

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Nedal Darif, Marco Rheinnecker, Kolja Hildenbrand, Thanat Chookajorn, Lilian P. Dorner, Jean‐Karim Hériché, Sara Henriksson, Charlotta Funaya, Franziska Hentzschel, Linda Sandblad, Oliver Billker, Yannick Schwab, Friedrich Frischknecht   +12 more
wiley   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source