Results 11 to 20 of about 14,920 (249)

The Coming-Out of Malaria Gametocytes [PDF]

Journal of Biomedicine and Biotechnology, 2010
The tropical disease malaria, which results in more than one million deaths annually, is caused by protozoan parasites of the genusPlasmodiumand transmitted by blood-feeding Anopheline mosquitoes. Parasite transition from the human host to the mosquito vector is mediated by gametocytes, sexual stages that are formed in human erythrocytes, which ...
Andrea Kuehn, Gabriele Pradel
  +6 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission-blocking target. [PDF]

FEBS Lett
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Huppertz F, Caturelli MS, Lehmann LS, Kurth F, Maier AG, Matuschewski K.   +5 more
europepmc   +2 more sources

Erythrocyte tropism of malarial parasites: The reticulocyte appeal

Frontiers in Microbiology, 2022
Erythrocytes are formed from the enucleation of erythroblasts in the bone marrow, and as erythrocytes develop from immature reticulocytes into mature normocytes, they undergo extensive cellular changes through their passage in the blood. During the blood
Yew Wai Leong, Bruce Russell, Benoit Malleret, Benoit Malleret, Laurent Rénia, Laurent Rénia, Laurent Rénia   +6 more
doaj   +1 more source

Plasmodium vivax gametocytes and transmission

Parasitology International, 2022
Malaria elimination means cessation of parasite transmission. At present, the declining malaria incidence in many countries has made elimination a feasible goal. Transmission control has thus been placed at the center of the national malaria control programs.
Sirasate, Bantuchai, Hisham, Imad, Wang, Nguitragool   +2 more
openaire   +2 more sources

School-based screening and treatment may reduce P. falciparum transmission

Scientific Reports, 2021
In areas where malaria remains entrenched, novel transmission-reducing interventions are essential for malaria elimination. We report the impact screening-and-treatment of asymptomatic Malawian schoolchildren (n = 364 in the rainy season and 341 in the ...
Lauren M. Cohee, Clarissa Valim, Jenna E. Coalson, Andrew Nyambalo, Moses Chilombe, Andrew Ngwira, Andy Bauleni, Karl B. Seydel, Mark L. Wilson, Terrie E. Taylor, Don P. Mathanga, Miriam K. Laufer   +11 more
doaj   +1 more source

The activity of methylene blue against asexual and sexual stages of Plasmodium vivax

Frontiers in Cellular and Infection Microbiology, 2023
Methylene blue (MB) is an alternative for combating drug-resistant malaria parasites. Its transmission-blocking potential has been demonstrated in vivo in murine models, in vitro, and in clinical trials.
Camila Fabbri, Camila Fabbri, Glenda Quaresma Ramos, Glenda Quaresma Ramos, Glenda Quaresma Ramos, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Alexandre Oliveira Trindade, Luis Carlos Salazar-Alvarez, Juliana Costa Ferreira Neves, Juliana Costa Ferreira Neves, Ivanildes dos Santos Bastos, Ivanildes dos Santos Bastos, Allyson Guimarães Costa, Allyson Guimarães Costa, Allyson Guimarães Costa, Marcus Vinicius Guimarães Lacerda, Marcus Vinicius Guimarães Lacerda, Marcus Vinicius Guimarães Lacerda, Wuelton Marcelo Monteiro, Wuelton Marcelo Monteiro, Fabio Trindade Maranhão Costa, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes   +27 more
doaj   +1 more source

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
A Dawn, A Heiber, A Merckx, A Pantaleo, A Sudo, AE Bianco, Audrey Lorthiois, Bernina Naissant, C Lavazec, C Lavazec, C Syin, Catherine Lavazec, CJ Taylor, D Yokoyama, DA Baker, David A. Baker, DK Muhia, Dominique Soldati-Favre, Donatella Taramelli, E Farfour, E Lasonder, E Ling, Eloise Thompson, F Hawking, F Silvestrini, F Silvestrini, Florence Breil, Florian Dupuy, G Deplaine, Ghania Ramdani, Gordon Langsley, HM Taylor, I Koshino, J Bain, K Leykauf, Kenneth Vernick, KM Tang, L Chen, L McRobert, L Wentzinger, LK Read, M Aingaran, M Boolell, M Hliscs, M Tiburcio, M Tiburcio, ME Smalley, MJ Lopez-Barragan, MK Dearnley, MW Dixon, N Goto, N Mohandas, Odile Mercereau-Puijalon, QL Fivelman, R Aguilar, R Joice, RE Sinden, RE Sinden, RL Coppel, Ross Cummings, RW Moon, S D'Alessandro, S Kunz, S Sanyal, SM Knebel, SP Davies, SP Kim, T Bousema, T Harrison, T Ono, T Seebeck, W Trager, WB Smith 2nd, Yoann Duffier, Yolanda Corbett   +74 more
core   +24 more sources

HIV-1 Infection Is Associated With Increased Prevalence and Abundance of Plasmodium falciparum Gametocyte-Specific Transcripts in Asymptomatic Adults in Western Kenya

Frontiers in Cellular and Infection Microbiology, 2021
As morbidity and mortality due to malaria continue to decline, the identification of individuals with a high likelihood of transmitting malaria is needed to further reduce the prevalence of malaria.
Deborah M. Stiffler, Janet Oyieko, Carolyne M. Kifude, David M. Rockabrand, Shirley Luckhart, V. Ann Stewart   +5 more
doaj   +1 more source

Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development. [PDF]

, 2014
BACKGROUND: Gametocytes are the Plasmodium life stage that is solely responsible for malaria transmission. Despite their important role in perpetuating malaria, gametocyte differentiation and development is poorly understood.
Delves, MJ, Lamour, SD, Saric, J, Straschil, U   +3 more
core   +3 more sources

Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology [PDF]

, 2014
One of the critical gaps in malaria transmission biology and surveillance is our lack of knowledge about Plasmodium falciparum gametocyte biology, especially sexual dimorphic development and how sex ratios that may influence transmission from the human ...
Dinglasan, R. R., Goldowitz, I., Graham, D. R., King, J. G., Marti, M., Mathias, D. K., Moss, E., Pastrana-Mena, R., Tao, D., Tripathi, A., Ubaida-Mohien, C.   +10 more
core   +1 more source