Results 31 to 40 of about 14,920 (249)

Quantifying Reductions in Plasmodium falciparum Infectivity to Mosquitos: A Sample Size Calculator to Inform Clinical Trials on Transmission-Reducing Interventions

Frontiers in Immunology, 2022
Malaria transmission depends on the presence of mature Plasmodium transmission stages (gametocytes) that may render blood-feeding Anopheles mosquitos infectious.
Jordache Ramjith, Jordache Ramjith, Manon Alkema, John Bradley, Alassane Dicko, Chris Drakeley, Will Stone, Teun Bousema   +7 more
doaj   +1 more source

Probing Plasmodium falciparum sexual commitment at the single-cell level [PDF]

, 2018
Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure.
Birren, Bruce W., Brancucci, Nicolas M.B., De Niz, Mariana, Marti, Matthias, Neafsey, Daniel E., Ravel, Deepali, Sollelis, Lauriane, Straub, Timothy J., Voss, Till S.   +8 more
core   +4 more sources

Revisiting gametocyte biology in malaria parasites [PDF]

FEMS Microbiology Reviews, 2019
ABSTRACT Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito vector. They are present at low levels in blood circulation and significant knowledge gaps exist in their biology. Recent reductions in the global malaria burden have brought the possibility of elimination and eradication, with renewed ...
Ngotho, Priscilla, Blancke Soares, Alexandra, Hentzschel, Franziska, Achcar, Fiona, Bertuccini, Lucia, Marti, Matthias   +5 more
openaire   +2 more sources

Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

Malaria Journal, 2017
Background Mosquito-feeding assays are important tools to guide the development and support the evaluation of transmission-blocking interventions. These functional bioassays measure the sporogonic development of gametocytes in blood-fed mosquitoes ...
Isaie J. Reuling, Will J. R. Stone, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Wouter Graumans, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein   +8 more
doaj   +1 more source

Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionUnderstanding the human immune response to Plasmodium falciparum gametocytes and its association with gametocytemia is essential for understanding the transmission of malaria as well as progressing transmission blocking vaccine candidates ...
Katherine O’Flaherty, Jo-Anne Chan, Jo-Anne Chan, Jo-Anne Chan, Julia C. Cutts, Julia C. Cutts, Sophie G. Zaloumis, Elizabeth A. Ashley, Elizabeth A. Ashley, Aung Pyae Phyo, Damien R. Drew, Arjen M. Dondorp, Arjen M. Dondorp, Nicholas P. Day, Nicholas P. Day, Mehul Dhorda, Mehul Dhorda, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, Mayfong Mayxay, Mayfong Mayxay, M. Abul Faiz, Olugbenga A. Mokuolu, Marie A. Onyamboko, Caterina Fanello, Caterina Fanello, Caterina Fanello, Eizo Takashima, Takafumi Tsuboi, Michael Theisen, Michael Theisen, Francois Nosten, Francois Nosten, Francois Nosten, James G. Beeson, James G. Beeson, James G. Beeson, James G. Beeson, Julie A. Simpson, Nicholas J. White, Nicholas J. White, Freya J. I. Fowkes, Freya J. I. Fowkes, Freya J. I. Fowkes   +50 more
doaj   +1 more source

Detection of Plasmodium falciparum male and female gametocytes and determination of parasite sex ratio in human endemic populations by novel, cheap and robust RTqPCR assays [PDF]

, 2017
The presence of Plasmodium falciparum gametocytes in peripheral blood is essential for human to mosquito parasite transmission. The detection of submicroscopic infections with gametocytes and the estimation of the gametocyte sex ratio are crucial to ...
Alano, Pietro, Avellino, Pamela, Lombardo, Fabrizio, Mangano, Valentina Dianora, Modiano, David, Ouédraogo, Jean Bosco, Santolamazza, Federica, Siciliano, Giulia, Yao, Franck Adama   +8 more
core   +2 more sources

Critical Steps of Plasmodium falciparum Ookinete Maturation [PDF]

, 2020
The egress and fertilization of Plasmodium gametes and development of a motile ookinete are the first crucial steps that mediate the successful transmission of the malaria parasites from humans to the Anopheles vector. However, limited information exists
Alano, P., Costa, G., Levashina, E., Siciliano, G., Suárez-Cortés, P., Valleriani, A.   +5 more
core   +1 more source

Prospective evaluation of BDProbeTec strand displacement amplification (SDA) system for diagnosis of tuberculosis in non-respiratory and respiratory samples. [PDF]

, 2004
Nucleic acid amplification techniques (NAATs) have been demonstrated to make significant improvements in the diagnosis of tuberculosis (TB), particularly in the time to diagnosis and the diagnosis of smear-negative TB. The BD ProbeTec strand displacement
Billington, OJ, Gillespie, SH, Gosling, RD, Ling, CL, Lipman, MC, McHugh, TD, Patel, S, Pope, CF   +7 more
core   +2 more sources

Transmission immunity in malaria: reflections on the underlying immune mechanisms during natural infections and following artificial immunization

Memorias do Instituto Oswaldo Cruz, 1992
Malaria transmission-blocking immunity has been studied in natural malaria infections in man, during infections in animals and following artificial immunization of animals with sexual stage malaria parasites.
Richard Carter, Kamini Mendis
doaj   +1 more source

Erythrocyte Membrane Makeover by Plasmodium falciparum Gametocytes [PDF]

Frontiers in Microbiology, 2019
Plasmodium falciparum sexual parasites, called gametocytes, are the only parasite stages responsible for transmission from humans to Anopheles mosquitoes. During their maturation, P. falciparum gametocytes remodel the structural and mechanical properties of the membrane of their erythrocyte host.
Gaëlle Neveu, Gaëlle Neveu, Catherine Lavazec, Catherine Lavazec   +3 more
openaire   +4 more sources