Results 41 to 50 of about 14,920 (249)

Improving statistical inference on pathogen densities estimated by quantitative molecular methods: malaria gametocytaemia as a case study [PDF]

, 2015
BACKGROUND: Quantitative molecular methods (QMMs) such as quantitative real-time polymerase chain reaction (q-PCR), reverse-transcriptase PCR (qRT-PCR) and quantitative nucleic acid sequence-based amplification (QT-NASBA) are increasingly used to ...
A Gelman, André Lin Ouédraogo, B Hoadley, C Eisenhart, C Fraser, C Osborne, CE McCulloch, Cornelus Hermsen, D Lunn, DJ Lunn, DJ Spiegelhalter, DL Massart, EC Fieller, F Ferre, FA Graybill, G Marsaglia, GK Shulka, HG Niesters, HS Mubarak El, J Jiang, J Wain, JF Cohen, JH McCulloch, JM Ruijter, JN Miller, JO Beer De, JS Murray, JS Yuan, K Danzer, K Khairnar, KK Lai, LC Okell, LJ Naszódi, M Plummer, M Sivaganesan, M Woodhead, Martin Walker, María-Gloria Basáñez, NM Ferguson, P Schneider, P Schneider, P Vankeerberghen, PF Mens, R Wampfler, S Nadarajah, SA Bustin, SA Bustin, SA Fiscus, T Nolan, T Ponnudurai, TD Schmittgen, Teun Bousema, Thomas S Churcher, TS Churcher, World Health Organization, Y Karlen, YW Tang   +56 more
core   +4 more sources

Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum. [PDF]

, 2017
Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P.
Batugedara, Gayani, Bunnik, Evelien M, Le Roch, Karine G, Lee, Michael, Lu, Xueqing Maggie, Prudhomme, Jacques   +5 more
core   +1 more source

Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach [PDF]

, 2019
We introduce an agent-based model describing a susceptible-infectious-susceptible (SIS) system of humans and mosquitoes to predict malaria epidemiological scenarios in realistic biological conditions.
Lind, Pedro G., Louçã, Jorge, Mendes, António M., Sequeira, João   +3 more
core   +2 more sources

Differential infectivity of gametocytes after artemisinin-based combination therapy of uncomplicated falciparum malaria

African Journal of Laboratory Medicine, 2018
Background: Most malaria-endemic countries use artemisinin-based combination therapy (ACT) as their first-line treatment. ACTs are known to be highly effective on asexual stages of the malaria parasite.
Dinkorma T. Ouologuem, Cheick O. Kone, Bakary Fofana, Bakary Sidibe, Amadou H. Togo, Demba Dembele, Sekou Toure, Sekou Koumare, Ousmane Toure, Issaka Sagara, Abdoulaye Toure, Adama Dao, Ogobara K. Doumbo, Abdoulaye A. Djimde   +13 more
doaj   +1 more source

Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes

Frontiers in Cellular and Infection Microbiology, 2022
Despite significant developments towards malaria reduction, parasite transmission in the common context of HIV-1 co-infection and treatment for one or both infections has not been fully characterized.
Ashleigh Roberds, Carolyne Kifude, Janet Oyieko, Stephen Ocholla, James Mutunga, James Mutunga, David Oullo, Charles Waga, Zhaozhang Li, Shirley Luckhart, V. Ann Stewart   +10 more
doaj   +1 more source

Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages [PDF]

, 2009
Malaria pathology is caused by multiplication of asexual parasites within erythrocytes, whereas mosquito transmission of malaria is mediated by sexual precursor cells (gametocytes).
Beitz, Billker, Bork, Bystrom, CCP4, Daily, Darbon, Deitsch, Duraisingh, Emsley, Feese, Fivelman, Gouet, Greenwood, Guan, Hansen, Herzberg, Holz, Hurley, Hurley, Liu, Mair, McCabe, Murshudov, Ormo, Perrakis, Promeneur, Roudier, Sambrook, Santiago, Sharp, Studier, Trager, Vagin, Vial, Witteveen, Yeh, Young   +37 more
core   +4 more sources

Identification and analysis of Eimeria nieschulzi gametocyte genes reveal splicing events of gam genes and conserved motifs in the wall-forming proteins within the genus Eimeria (Coccidia, Apicomplexa)

Parasite, 2017
The genus Eimeria (Apicomplexa, Coccidia) provides a wide range of different species with different hosts to study common and variable features within the genus and its species.
Wiedmer Stefanie, Erdbeer Alexander, Volke Beate, Randel Stephanie, Kapplusch Franz, Hanig Sacha, Kurth Michael   +6 more
doaj   +1 more source

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

Malaria Journal, 2010
Background There is renewed acknowledgement that targeting gametocytes is essential for malaria control and elimination efforts. Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation ...
Sawa Patrick, Omar Sabah, Griffin Jamie T, Shekalaghe Seif, Okell Lucy, Bousema Teun, Sutherland Colin, Sauerwein Robert, Ghani Azra C, Drakeley Chris   +9 more
doaj   +1 more source

Ultrastructure and function of mitochondria in gametocytic stage of Plasmodium falciparum

Parasite, 2000
Morphological properties of the mitochondrial organelles in the asexual and sexual gametocytic stages of Plasmodium falciparum have been analyzed and found to be markedly different.
Krungkrai J., Prapunwattana P., Krungkrai S.R.   +2 more
doaj   +1 more source

Gametocyte carriage in Plasmodium falciparum-infected travellers [PDF]

Malaria Journal, 2013
Abstract Background Gametocytes are the sexual stage of Plasmodium parasites. The determinants of gametocyte carriage have been studied extensively in endemic areas, but have rarely been explored in travellers with malaria.
Roberts, CH, Armstrong, M, Zatyka, E, Boadi, S, Warren, S, Chiodini, PL, Sutherland, CJ, Doherty, T   +7 more
openaire   +6 more sources