Results 41 to 50 of about 7,720 (145)

Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission. [PDF]

PLoS ONE, 2009
BACKGROUND:Man to mosquito transmission of malaria depends on the presence of the sexual stage parasites, gametocytes, that often circulate at low densities.
André Lin Ouédraogo, Teun Bousema, Petra Schneider, Sake J de Vlas, Edith Ilboudo-Sanogo, Nadine Cuzin-Ouattara, Issa Nébié, Will Roeffen, Jan Peter Verhave, Adrian J F Luty, Robert Sauerwein   +10 more
doaj   +1 more source

Coordinated regulation of gene expression inPlasmodiumfemale gametocytes by two transcription factors [PDF]

, 2023
Yuho Murata, Tsubasa Nishi, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda   +4 more
openalex   +1 more source

Heritability of the human infectious reservoir of malaria parasites. [PDF]

PLoS ONE, 2010
BackgroundStudies on human genetic factors associated with malaria have hitherto concentrated on their role in susceptibility to and protection from disease. In contrast, virtually no attention has been paid to the role of human genetics in eliciting the
Yaye Ramatoulaye Lawaly, Anavaj Sakuntabhai, Laurence Marrama, Lassana Konate, Waraphon Phimpraphi, Cheikh Sokhna, Adama Tall, Fatoumata Diène Sarr, Chayanon Peerapittayamongkol, Chalisa Louicharoen, Bradley S Schneider, Anaïs Levescot, Arthur Talman, Isabelle Casademont, Didier Menard, Jean-François Trape, Christophe Rogier, Jaranit Kaewkunwal, Thanyachai Sura, Issarang Nuchprayoon, Frederic Ariey, Laurence Baril, Pratap Singhasivanon, Odile Mercereau-Puijalon, Rick Paul   +24 more
doaj   +1 more source

Plasmodium falciparum gametocyte dynamics after pyronaridine–artesunate or artemether–lumefantrine treatment

Malaria Journal, 2018
Background Artemisinin-based combinations differ in their impact on gametocyte prevalence and density. This study assessed female and male gametocyte dynamics after treating children with uncomplicated Plasmodium falciparum malaria with either ...
Johanna M. Roth, Patrick Sawa, George Omweri, Victor Osoti, Nicodemus Makio, John Bradley, Teun Bousema, Henk D. F. H. Schallig, Pètra F. Mens   +8 more
doaj   +1 more source

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

eLife, 2018
Background: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is ...
Isaie J Reuling, Lisanne A van de Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Quirijn de Mast, André J van der Ven, Karen Ivinson, Cornelus C Hermsen, Sake de Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W Sauerwein, Teun Bousema   +20 more
doaj   +1 more source

Real-time PCR assays for detection and quantification of early P. falciparum gametocyte stages

Scientific Reports, 2021
The use of quantitative qRT-PCR assays for detection and quantification of late gametocyte stages has revealed the high transmission capacity of the human malaria parasite, Plasmodium falciparum. To understand how the parasite adjusts its transmission in
Amal A. H. Gadalla, Giulia Siciliano, Ryan Farid, Pietro Alano, Lisa Ranford-Cartwright, James S. McCarthy, Joanne Thompson, Hamza A Babiker   +7 more
doaj   +1 more source

Sex-specific Separation of Plasmodium falciparum Gametocyte Populations [PDF]

, 2021
Melanie C. Ridgway, Daniela Cihalova, Alexander G. Maier   +2 more
openalex   +1 more source

Plasmodium falciparumincreases its investment in gametocytes in the wet season in asymptomatic individuals [PDF]

, 2020
Colins O. Oduma, Sidney Ogolla, Harrysone Atieli, Bartholomew N. Ondigo, Ming‐Chieh Lee, Andrew K. Githeko, Arlene E. Dent, James W. Kazura, Guiyun Yan, Cristian Koepfli   +9 more
openalex   +1 more source

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

eLife
It is currently unknown whether all Plasmodium falciparum-infected mosquitoes are equally infectious. We assessed sporogonic development using cultured gametocytes in the Netherlands and naturally circulating strains in Burkina Faso.
Chiara Andolina, Wouter Graumans, Moussa Guelbeogo, Geert-Jan van Gemert, Jordache Ramijth, Soré Harouna, Zongo Soumanaba, Rianne Stoter, Marga Vegte-Bolmer, Martina Pangos, Photini Sinnis, Katharine Collins, Sarah G Staedke, Alfred B Tiono, Chris Drakeley, Kjerstin Lanke, Teun Bousema   +16 more
doaj   +1 more source

Modeling the impact of Plasmodium falciparum sexual stage immunity on the composition and dynamics of the human infectious reservoir for malaria in natural settings.

PLoS Pathogens, 2018
Malaria transmission remains high in Sub-Saharan Africa despite large-scale implementation of malaria control interventions. A comprehensive understanding of the transmissibility of infections to mosquitoes may guide the design of more effective ...
André Lin Ouédraogo, Philip A Eckhoff, Adrian J F Luty, Will Roeffen, Robert W Sauerwein, Teun Bousema, Edward A Wenger   +6 more
doaj   +1 more source