Results 101 to 110 of about 110,079 (354)

Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies

open access: yesChemistry – A European Journal, EarlyView.
This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley   +1 more source

Potentiation of gamma aminobutyric acid receptors (GABAAR) by Ethanol: How are inhibitory receptors affected?

open access: yesFrontiers in Cellular Neuroscience, 2016
In recent years there has been an increase in the understanding of ethanol actions on the type A -aminobutyric acid chloride channel (GABAAR), a member of the pentameric ligand gated ion channels (pLGICs).
Benjamin eFörstera   +3 more
doaj   +1 more source

GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations [PDF]

open access: yes, 2003
Gamma (30–80 Hz) oscillations occur in mammalian electroencephalogram in a manner that indicates cognitive relevance. In vitro models of gamma oscillations demonstrate two forms of oscillation: one occurring transiently and driven by discrete afferent ...
A. Bibbig   +25 more
core   +2 more sources

Surveillance of Phenibut in Wastewater During a Brazilian Carnival

open access: yesDrug Testing and Analysis, EarlyView.
This study reports the first detection of phenibut in Brazilian wastewater. Phenibut, a substance readily sold online to improve concentration, reaches wastewater treatment plants (WWTPs) after consumption by the population. Samples from WWTPs in the cities of Recife and Olinda in Northeastern Brazil were collected during the world's largest Carnival ...
Bruna R. de S. Gomes   +5 more
wiley   +1 more source

Prebiotic Organic Globules [PDF]

open access: yes, 2010
Analogs of organic globules observed in carbonaceous chondrite meteorites and in interplanetary dust particles and of rod to spherical structures observed in terrestrial archean microstructures have been synthesized in our experiments conducted with ...
Marie-Paule Bassez, Yoshinori Takano
core   +1 more source

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document

open access: yesEuropean Journal of Heart Failure, EarlyView.
Main categories of harmful drugs in heart failure. CCB, calcium channel blocker; DPP4i, dipeptidyl peptidase‐4 inhibitor; HER2‐TT, human epidermal growth factor receptor 2‐targeted therapy; NSAID, non‐steroidal anti‐inflammatory drug; TKI, tyrosine kinase inhibitor; TZD, thiazolidinedione; VEGF Inh, vascular endothelial growth factor inhibitor.
Amr Abdin   +16 more
wiley   +1 more source

Excitability of the motor cortex in patients with migraine changes with the time elapsed from the last attack [PDF]

open access: yes, 2017
BACKGROUND: Motor-evoked potentials (MEPs) produced by single-pulse transcranial magnetic stimulation (TMS) of the motor cortex can be an objective measure of cortical excitability.
COPPOLA, GIANLUCA   +6 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

open access: yesEpilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Gamma-aminobutyric acid ameliorates gamma rays-induced oxidative stress in the small intestine of rats

open access: yesJournal of Basic and Applied Zoology, 2017
Background The current study aimed to evaluate the role of gamma-amino butyric acid (GABA) in modulating histopathological and biochemical disturbances in the rat’s small intestine following gamma radiation exposure. Results The results showed that whole
Amr M. Abd El-Hady   +3 more
doaj   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

open access: yes, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama   +4 more
core   +1 more source

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