Results 81 to 90 of about 108,344 (304)

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Effects of Lycopene and Sodium Valproate on Pentylenetetrazol-Induced Kindling in Mice

Iranian Journal of Medical Sciences, 2016
Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against ...
Vinay Kumar, Sandeep Kumar Sharma, K Nagarajan, Praveen Kumar Dixit   +3 more
doaj  

Enhancing the cellular uptake of Py–Im polyamides through next-generation aryl turns [PDF]

, 2012
Pyrrole–imidazole (Py–Im) hairpin polyamides are a class of programmable, sequence-specific DNA binding oligomers capable of disrupting protein–DNA interactions and modulating gene expression in living cells.
Baird, Belitsky, Best, Bijsterbosch, Bradford, Chenoweth, Chenoweth, Chenoweth, Cleutjens, Cohen, Crowley, David C. Montgomery, Dervan, Dervan, Dickinson, Dose, D’Adamio, Edelson, Edwards, Gissot, Herman, Hesselberth, Hsu, Hsu, Jacobs, Johnson, Jordan L. Meier, Krutzik, Kwon, Magee, Mapp, Matsuda, Meijsing, Mrksich, Muzikar, Nickols, Nickols, Nickols, Nishijima, Ohtsukia, Olenyuk, Peter B. Dervan, Poulin-Kerstien, Reddy, Riegman, Rucker, Schmidt, Schultz, So, Swalley, Tsai, Van Dyke, Vaquerizas, Vichai, Yao   +54 more
core   +2 more sources

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Preserved Function of Afferent Parvalbumin-Positive Perisomatic Inhibitory Synapses of Dentate Granule Cells in Rapidly Kindled Mice

Frontiers in Cellular Neuroscience, 2018
Parvalbumin- (PV-) containing basket cells constitute perisomatic GABAergic inhibitory interneurons innervating principal cells at perisomatic area, a strategic location that allows them to efficiently control the output and synchronize oscillatory ...
Marita G. Hansen, Litsa N. Ledri, Deniz Kirik, Merab Kokaia, Marco Ledri   +4 more
doaj   +1 more source

Ametryn removal by Metarhizium brunneum: Biodegradation pathway proposal and metabolic background revealed [PDF]

, 2018
Ametryn is a representative of a class of s-triazine herbicides absorbed by plant roots and leaves and characterized as a photosynthesis inhibitor. It is still in use in some countries in the farming of pineapples, soybean, corn, cotton, sugar cane or ...
Abigail, Allan, Anna Kuśmierska, Bernat, Bernat, Borges, Chen, Chen, Chirnside, Długoński, Elbashir, Fang, Fujii, Gao, Govantes, Grillo, Hayes, Ji, Krishnan, Lee, Liang, Liu, Liu, Lobos, Ma, Navaratna, Noguchi, Payá, Pereira, Peters, Prosen, Przemysław Bernat, QuEChERS, Rafał Szewczyk, Rocha, Różalska, Sandoval-Carrasco, Scialli, Shah, Signorelli, Soboń, Solomon, Stoker, Szewczyk, Szewczyk, Tejada, Tripathi, Velisek, World Health Organization   +48 more
core   +1 more source

Impact of secured prescription implementation on ambulatory pregabalin use in France: A regional assessment in the French Nouvelle‐Aquitaine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The French authorities mandated the use of secure prescriptions for pregabalin on May 2021. This study aimed to evaluate the impact of this measure on pregabalin use and misuse in Nouvelle‐Aquitaine, a southwestern French region with around six million inhabitants.
Maika Munech‐Herran, Véronique Moysan, Bruno Lescarret, Clément Mathieu, Antoine Pariente, Nicolas Rousselot   +5 more
wiley   +1 more source

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]

, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong, Jones, Emily A, Najm, Ramsey   +2 more
core   +1 more source

Complete genome sequence of the gamma-aminobutyric acid-producing strain Streptococcus thermophilus APC151 [PDF]

, 2017
Here is presented the whole-genome sequence of Streptococcus thermophiles APC151, isolated from a marine fish. This bacterium produces gamma-aminobutyric acid (GABA) in high yields and is biotechnologically suitable to produce naturally GABA-enriched ...
Arboleya, Silvia, Linares, Daniel M., Ross, R. Paul, Stanton, Catherine   +3 more
core   +1 more source

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, EarlyView.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source