Results 61 to 70 of about 66,550 (299)

Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis: A shared phenotype across brain‐expressed sodium channelopathies

Epilepsia, EarlyView.
Abstract Objective Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis (NDEEMA) represents the most severe end of the gain‐of‐function (GOF) SCN1A disorder spectrum. Sporadic cases of congenital arthrogryposis have also been reported in individuals with SCN2A‐, SCN3A‐, and SCN8A‐related developmental and ...
Sopio Gverdtsiteli, Sebastian Ortiz, Tobias Brünger, Francesca Furia, Carmen Barba, Trine Bjørg‐Hammer, Ingo Borggraefe, Roberto Caraballo, Sebahattin Cirak, Alberto Espeche, Walid Fazeli, Renzo Guerrini, Matias Juanes, Karin Kassahn, Maria Kinali, Johannes Krämer, Judith Kröll, Maria Concepción Miranda Herrero, Renske Oegema, Katrin Ounap, Oscar Peñuela, Konrad Platzer, Asuri Narayan Prasad, Aurora Pujol, Karit Reinson, Alfonso Represa, Eugenia Roza, Gabriela Reyes Valenzuela, Agustí Rodríguez‐Palmero, Suzanne Sallevelt, Maria Iciar Sanchez‐Albiusa, Ingrid E. Scheffer, Cory Smid, Carl E. Stafstrom, Eva‐Lena Stattin, Jen R. Suarez, Steffen Syrbe, Kette D. Valente, Matias Wagner, Saskia Wortmann, Elena Gardella, Dennis Lal, Andreas Brunklaus, Rikke S. Møller   +43 more
wiley   +1 more source

Synergy of piracetam and aminalon in the cerebroprotective effect of olatropyl.

Medičnì Perspektivi, 2018
Optimization of pharmacotherapy of neurological and psychosomatic diseases led to the creation of com­bined medicines containing two or more components with different mechanisms of action, differently affecting the pathogenesis and clinical ...
V. I. Mamchur, S. N. Dronov
doaj   +1 more source

CaMKIIβ insufficiency disrupts cortical networks, producing aberrant low‐gamma oscillations and seizure susceptibility

Epilepsia, EarlyView.
Abstract Objective Pathogenic variants in the calcium/calmodulin‐dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear.
Hiroki Mutoh, Kazushi Aoto, Atsuo Fukuda, Hirotomo Saitsu   +3 more
wiley   +1 more source

Gamma-aminobutyric acid mediates nicotine biosynthesis in tobacco under flooding stress

Plant Diversity, 2016
Gamma-aminobutyric acid (GABA) is a four-carbon non-protein amino acid conserved from bacteria to plants and vertebrates. Increasing evidence supports a regulatory role for GABA in plant development and the plant's response to environmental stress.
Xiaoming Zhang, Hua-ming Lin, Hong Hu, Xiangyang Hu, Liwei Hu   +4 more
doaj   +1 more source

Dual role of spreading depolarization in an epileptic focus

Epilepsia, EarlyView.
Abstract Objective Spreading depolarizations (SDs) are often associated with epileptic discharges. Although SDs are traditionally thought to contribute to postictal depression and termination of epileptic discharges, seizures may also occur during SDs or may even follow SDs, suggesting that interactions between SD and seizures are more complex.
Daria Vinokurova, Karina Tukhvatullina, Roustem Khazipov, Azat Nasretdinov   +3 more
wiley   +1 more source

STANDARDIZATION OF THE AMINO ACIDS TABLETS BY DIFFUSE REFLECTION IR SPECTROSCOPY

Разработка и регистрация лекарственных средств, 2019
The possibility of using the infrared spectra of the diffuse reflection in the near and medium field of standardization and optimization of the technological process of tablet forms of aliphatic amino acids: butyric, β-alanine, γ-aminobutyric acid. Shown
A. A. Maryin, I. G. Tansereva, Y. G. Chistohin   +2 more
doaj  

Gamma-aminobutyric acid improves cold tolerance of wheat seedlings

Plant, Soil and Environment
To provide a new agent to enhance wheat cold tolerance, we investigated the impacts of gamma-aminobutyric acid (GABA) on wheat antioxidant and photosynthetic capacity and growth parameters under cold stress (CS).
Changjuan Shan, Zhimin Yuan
doaj   +1 more source

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze, Robyn Whitney, Dorothée Ville, Nathalie Villeneuve, Anna‐Maria Hartmann, Lisa Becker, Jens Hausmann, Jinwei Zhang, Cathy Brier, Lucie I. Pisella, Perrine Friedel, Audrey Labalme, Eudeline Alix, Nicolas Chatron, Damien Sanlaville, Sylvie Gory‐Fauré, Eric Denarier, Christophe Porcher, Gaetan Lesca, Igor Medina   +19 more
wiley   +1 more source

Effects of Lycopene and Sodium Valproate on Pentylenetetrazol-Induced Kindling in Mice

Iranian Journal of Medical Sciences, 2016
Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against ...
Vinay Kumar, Sandeep Kumar Sharma, K Nagarajan, Praveen Kumar Dixit   +3 more
doaj  

Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway

Molecular Pain, 2018
Background Neuropathic pain is observed in patients as chemotherapeutic oxaliplatin is used to treat metastatic digestive tumors; however, the mechanisms responsible for hyperalgesia are not well understood.
Dongsheng Xu, Hui Zhao, Han Gao, Huiling Zhao, Dandan Liu, Jing Li   +5 more
doaj   +1 more source