Results 181 to 190 of about 108,344 (304)

Gamma-aminobutyric acid attenuates cortisol-induced damage in human colorectal adenocarcinoma cells via Nrf2 signaling. [PDF]

Naturwissenschaften
Liu Y, Wu Y.
europepmc   +1 more source

Crystal structure of the plant GABA aminotransferase AtGABA‐T from Arabidopsis thaliana

Acta Crystallographica Section F, EarlyView.
The crystal structure of A. thaliana γ‐aminobutyric acid aminotransferase (GABA‐T) reveals that plant GABA‐T belongs to the class III aminotransferase family and employs a C‐terminal arginine residue for γ‐aminobutyric acid recognition, in contrast to the N‐terminal arginine used by class II enzymes.γ‐Aminobutyric acid aminotransferase (GABA‐T) is a ...
Naofumi Okoda, Suguru Okuda, Kenta Tsutsumi, Hideaki Itoh, Ken Okamoto, Hiroshi Kawakami, Kaori Sano, Kenji Kobata, Koji Nagata   +8 more
wiley   +1 more source

The beneficial effect of gamma aminobutyric acid on diabetic nephropathy in type 2 diabetic rat model and their offspring. [PDF]

Res Pharm Sci
Rezazadeh H, Maghareh-Dehkordi S, Touliat MV, Talebi A, Soltani N.   +4 more
europepmc   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Fluorine-18 Radiolabeled Single-Chain Antibody Variable Fragment 1F4 Targets α1-Subunit Gamma-Aminobutyric Acid Type A Receptors in Mice. [PDF]

J Med Chem
García de Lucas Á, Samani NA, Moisio O, Kovacs L, Savela R, Soini SL, Oksanen S, Helin JS, Rajander J, Airaksinen AJ, Lamminmäki U, López-Picón F.   +11 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Perfluorooctanesulfonic acid (PFOS) antagonizes gamma-aminobutyric acid (GABA) receptors in larval zebrafish and mammalian models. [PDF]

Toxicol Sci
Owen R, de Macedo G, Nerlich J, Scharkin I, Bartmann K, Döbler J, Engelmann B, Rolle-Kampczyk UE, Leuthold D, Gutsfeld S, Schweiger N, Tal T.   +11 more
europepmc   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

British Journal of Pharmacology, EarlyView.
Background and Purpose Maternal hypoxia is a recognised risk factor for neurodevelopmental disorders in offspring. Although rodent models of hypoxia have been reported, the detailed pathogenesis of maternal hypoxia‐induced neurodevelopmental disorders remains unclear.
Kentaro Tokudome, Masaaki Ueki, Takujiro Homma, Shinji Matsunaga, Saki Shimizu, Yukihiro Ohno, Shuhei Tomita   +6 more
wiley   +1 more source

Construction of a co-reaction system for ethanol-promoted gamma-aminobutyric acid synthesis by Pediococcus pentosaceus. [PDF]

Amino Acids
Yang SY, Li YJ, Hong WC.
europepmc   +1 more source