Results 221 to 230 of about 110,079 (354)

Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro

Epilepsia, EarlyView.
Abstract Objective Autoimmune encephalitis (AE) is characterized by inflammatory processes in the central nervous system and frequently presents with seizures. Even though an ictogenic potential has been shown for some antibodies against neuronal surface antigens (NSAbs), AE pathophysiology is complex, and NSAbs‐independent mechanisms are likely to ...
Sara Prevosti, Alessio Passalacqua, Maria Cristina Regondi, Giada D'Ambrosio, Alessandra Morano, Michele Romoli, Giulia Maira, Flavio Villani, Pietro Mattioli, Diego Franciotta, Andrea Stabile, Marco de Curtis, Matteo Gastaldi, Francesco Deleo, Laura Librizzi   +14 more
wiley   +1 more source

Astrocytic monoamine oxidase B (MAOB)-gamma-aminobutyric acid (GABA) axis as a molecular brake on repair following spinal cord injury. [PDF]

Signal Transduct Target Ther
Lee HY, Lee JM, Lee HL, Park J, An H, Park EK, Hwang SY, Yoon SL, Hwang GY, Kim KN, Nam MH, Lee SE, Kang H, Won J, Jang BK, Lee EH, Choi S, Park MG, Kim SW, Park KD, Lee S, Lee CJ, Ha Y.   +22 more
europepmc   +1 more source

Absence seizures and sleep–wake abnormalities in a rat model of GRIN2B neurodevelopmental disorder

Epilepsia, EarlyView.
Abstract Objective Pathogenic mutations in GRIN2B are an important cause of severe neurodevelopmental disorders resulting in epilepsy, autism, and intellectual disability. GRIN2B encodes the GluN2B subunit of N‐methyl‐d‐aspartate receptors (NMDARs), which are ionotropic glutamate receptors critical for normal development of the nervous system and ...
Katerina Hristova, Melissa C. M. Fasol, Niamh McLaughlin, Mohammad Sarfaraz Nawaz, Mehmet Taskiran, Ingrid Buller‐Peralta, Anjanette P. Harris, Andrew Sutherland, Alejandro Bassi, Adrian Ocampo‐Garces, Javier Escudero, Peter C. Kind, Alfredo Gonzalez‐Sulser   +12 more
wiley   +1 more source

Potential role of astrocyte on gamma-aminobutyric acid tone regulation during developmental period. [PDF]

Neural Regen Res
Ozkan E, Koh W.
europepmc   +1 more source

Synthesis of alkyl-substituted arecoline derivatives as .gamma.-aminobutyric acid uptake inhibitors

, 1986
Christian Mueller-Uri, E. SINGER, Wilhelm Fleischhacker   +2 more
openalex   +1 more source

Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction

Epilepsia, EarlyView.
Abstract SCN2A encodes for the alpha subunit of the voltage‐gated sodium channel NaV1.2, which is involved in action potential initiation and backpropagation in excitatory neurons. Currently, it is one of the highest monogenetic risk factors for both epilepsy and autism spectrum disorder.
Katelin E. J. Scott, Maria Fernanda Hermosillo Arrieta, Aislinn J. Williams   +2 more
wiley   +1 more source

Proteomic Learning of Gamma-Aminobutyric Acid (GABA) Receptor-Mediated Anesthesia. [PDF]

J Chem Inf Model
Jiang J, Chen L, Zhu Y, Shi Y, Qiu H, Zhang B, Zhou T, Wei GW.   +7 more
europepmc   +1 more source

Potassium–chloride cotransporter 2 activity dampens induced ictal‐like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients

Epilepsia, EarlyView.
The K⁺/Cl− cotransporter (KCC2) limits induced ictal‐like events and their spread in the supragranular layer of human neocortical slices from the seizure‐propagation zone of temporal lobe epilepsy patients. Cl⁻ extrusion is present in supragranular pyramidal neurons but limited under high somatic Cl⁻ load.
Alice Falck, Janna Lehnhoff, Mahraz Behbood, Egor Byvaltcev, Annette Aigner, Helena Radbruch, Pawel Fidzinski, Jan‐Hendrik Schleimer, Gabriel M. S. Janach, Noah Döhne, Julia Onken, Thilo Kalbhenn, Thomas Sauvigny, Rudolf A. Deisz, Susanne Schreiber, Martin Holtkamp, Ulf Strauss   +16 more
wiley   +1 more source

Anti-Gamma-Aminobutyric Acid B (GABA-B) Receptor Encephalitis: A Case Series Analyzing Treatment Modalities and Cancer Screening Recommendations. [PDF]

Cureus
Garza Hernandez S, Johnson H, Wagle B, Kiani Nia N.   +3 more
europepmc   +1 more source

Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of .gamma.-aminobutyric acid acting as selective GABA-A antagonists

, 1987
Camille G. Wermuth, Jean Bourguignon, Gilbert Schlewer, Jean Pierre Gies, Angèle Schoenfelder, Anita Melikian, Marie Jeanne Bouchet, Dominique Chantreux, Jean Charles Molimard   +8 more
openalex   +1 more source