Results 251 to 260 of about 110,079 (354)

A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures

open access: yesEpilepsia, EarlyView.
A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures. Abstract Objectives This randomized, double‐blind, placebo‐controlled study (NCT04557085), conducted in China, Japan, and the Republic of Korea, evaluated the efficacy and safety of ...
Sang Kun Lee   +20 more
wiley   +1 more source

Insights and progress on the biosynthesis, metabolism, and physiological functions of gamma-aminobutyric acid (GABA): a review. [PDF]

open access: yesPeerJ
Zhang Q   +16 more
europepmc   +1 more source

Epilepsy in dentatorubral–pallidoluysian atrophy: A systematic review and meta‐analysis

open access: yesEpilepsia, EarlyView.
Summary of key clinical and electrophysiological characteristics of DRPLA‐related epilepsy from a systematic review and meta‐analysis of 1,191 patients. DRPLA patients with epilepsy showed earlier disease onset, longer CAG repeat expansion, and a tendency toward paternal inheritance. EEG findings frequently included photoparoxysmal responses.
Toru Horinouchi   +10 more
wiley   +1 more source

Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats

open access: yesEpilepsia, EarlyView.
Abstract Objective For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produces robust seizure suppression in a range of seizure models.
Devin Palmer, Patrick A. Forcelli
wiley   +1 more source

A simple and effective method to enhance the level of gamma-aminobutyric acid in Chinese yam tubers while preserving its original appearance. [PDF]

open access: yesFood Chem X
Wang Q   +12 more
europepmc   +1 more source

Daily intermittent fasting is an effective multiscale treatment in preclinical models of absence epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Absence epilepsy is characterized by brief but frequent seizures with loss of consciousness. Existing treatments, which come with heavy side effects, are only partially effective and do not address the associated comorbidities, including cognitive and social deficits.
Coline Rulhe   +9 more
wiley   +1 more source

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