Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders [PDF]
, 2004 Background Cerebral palsy (CP) is an heterogeneous group of neurological disorders of movement and/or posture, with an estimated incidence of 1 in 1000 live births.
A Lernmark +57 more
core +2 more sources
Midazolam: an essential palliative care drug
Palliative Care and Social Practice, 2020 Midazolam is a commonly used benzodiazepine in palliative care and is considered one of the four essential drugs needed for the promotion of quality care in dying patients.
Eric Prommer
doaj +1 more source
Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]
, 2017 A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa +3 more
core +1 more source
The Importance of Gamma Aminobutyric Acid Produced by Lactic Acid Bacteria
Turkish Journal of Agriculture: Food Science and Technology, 2019 Gamma aminobutyric acid (GABA) is known as an important inhibitory neurotransmitter in the human brain. Recent studies have proved the beneficial effects of GABA on human health.
Seda Yalçınkaya +2 more
doaj +1 more source
International Journal of Preventive Medicine, 2021 Background: Diabetes mellitus (DM) is an endocrine disorder characterized by hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system (CNS) of humans and other mammals.
Hayder M Al-Kuraishy +5 more
doaj +1 more source
Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. [PDF]
, 2018 There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABAA-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models.
Dang, Hoa +4 more
core +3 more sources
Characterising the role of GABA and its metabolism in the wheat pathogen Stagonospora nodorum [PDF]
, 2015 A reverse genetics approach was used to investigate the role of γ-aminobutyric acid metabolism in the wheat pathogenic fungus Stagonospora nodorum. The creation of mutants lacking Sdh1, the gene encoding succinic semialdehyde dehydrogenase, resulted in ...
Mead, Oliver +3 more
core +1 more source
Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation [PDF]
, 2001 Gamma oscillations synchronized between distant neuronal populations may be critical for binding together brain regions devoted to common processing tasks.
A. Bibbig +51 more
core +3 more sources
Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. [PDF]
, 2014 Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread.
Chen, Zheying +4 more
core +1 more source
Cell Reports, 2018 Summary: Brown adipose tissue (BAT) is a metabolically active organ that contributes to the maintenance of systemic metabolism. The sympathetic nervous system plays important roles in the homeostasis of BAT and promotes its browning and activation ...
Ryutaro Ikegami +16 more
doaj +1 more source