Results 41 to 50 of about 66,533 (308)

GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections

Nature Communications, 2018
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in neuronal systems, but the potential role for such neurotransmitters on the immune system are emerging.
Jin Kyung Kim, Yi Sak Kim, Hye-Mi Lee, Hyo Sun Jin, Chiranjivi Neupane, Sup Kim, Sang-Hee Lee, Jung-Joon Min, Miwa Sasai, Jae-Ho Jeong, Seong-Kyu Choe, Jin-Man Kim, Masahiro Yamamoto, Hyon E. Choy, Jin Bong Park, Eun-Kyeong Jo   +15 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Gamma-aminobutyric acid mediates nicotine biosynthesis in tobacco under flooding stress

Plant Diversity, 2016
Gamma-aminobutyric acid (GABA) is a four-carbon non-protein amino acid conserved from bacteria to plants and vertebrates. Increasing evidence supports a regulatory role for GABA in plant development and the plant's response to environmental stress.
Xiaoming Zhang, Hua-ming Lin, Hong Hu, Xiangyang Hu, Liwei Hu   +4 more
doaj   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Effects of dietary supplementation of different levels of gamma-aminobutyric acid on reproductive performance, glucose intolerance, and placental development of gilts [PDF]

, 2023
Shuo Ma, Jinfeng Li, Hongxuan Ye, Shuangbo Huang, Zihao Huang, Deyuan Wu, Kaidi Ma, Junyan Xie, Yulong Yin, Chengquan Tan   +9 more
openalex   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Synergy of piracetam and aminalon in the cerebroprotective effect of olatropyl.

Medičnì Perspektivi, 2018
Optimization of pharmacotherapy of neurological and psychosomatic diseases led to the creation of com­bined medicines containing two or more components with different mechanisms of action, differently affecting the pathogenesis and clinical ...
V. I. Mamchur, S. N. Dronov
doaj   +1 more source

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

Advanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien, Aneeth Kakkanattu Arunkumar, Rosalind Cross, Emilie Sunnucks, Frank Vollmer   +4 more
wiley   +1 more source

Cervical dystonia: a disorder of the midbrain network for covert attentional orienting.

Frontiers in Neurology, 2014
While the pathogenesis of cervical dystonia remains unknown, recent animal and clinical experimental studies have indicated its probable mechanisms. Abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new ...
Michael eHutchinson, Michael eHutchinson, Tadashi eIsa, Anna eMolloy, Anna eMolloy, Laura eWilliams, Laura eWilliams, Okka eKimmich, Okka eKimmich, Fiona eMolloy, Helena eMoore, Daniel G Healy, Tim eLynch, Cathal eWalsh, John eButler, Richard eReilly, Richard eWalsh, Sean eO'Riordan, Sean eO'Riordan   +18 more
doaj   +1 more source