Results 61 to 70 of about 66,533 (308)

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Safety and pharmacokinetics of a novel potent GABA analogue crisugabalin in Chinese subjects with various degrees of renal impairment

British Journal of Clinical Pharmacology, EarlyView.
Aims Crisugabalin is a novel calcium channel α2δ subunit ligand and a highly selective oral gamma‐aminobutyric acid (GABA) analogue developed for the treatment of diabetic peripheral neuropathic pain (DPNP) and postherpetic neuralgia (PHN). This study investigated pharmacokinetic properties and safety of crisugabalin in subjects with renal impairment ...
Shibeilei Lin, Ye Wang, Chao Hu, Yanhuan Feng, Xi Tang, Ping Fu, Jia Miao   +6 more
wiley   +1 more source

Synergistic effects of gamma-aminobutyric acid and melatonin on seed germination and cadmium tolerance in tomato [PDF]

, 2023
Yiying Lv, Yongteng Zhao, Yuansheng He, Jiming Wang, Yuanxian Zheng, Xiaolong Chen, Feiyan Huang, Jiani Liu, Lei Yu   +8 more
openalex   +1 more source

Rubrolides A, D, P, T, U: Total Syntheses and Antibacterial Evaluation of Highly Brominated Marine Natural Products

ChemistryEurope, EarlyView.
Following the Danube Flow. The first total syntheses of highly brominated rubrolides T, U, and U‐analog, together with the efficient and divergent syntheses of rubrolides A, D, and P. The dibrominated key intermediate, obtained via a Suzuki‐Miyaura cross‐coupling reaction, is the centerpiece of the synthesis.
Jasmin Janneschütz, Paul G. Schebek, Alexander Meyer, Celina Haller, Sophia Khom, Wolfgang R. Streit, Ifey Alio, Nina Schützenmeister   +7 more
wiley   +1 more source

INHIBITORY NEUROTRANSMITTERS AND THEIR INFLUENCE ON TUMOR IN PATIENTS WITH GLIOMAS

Сибирский онкологический журнал, 2016
The review deals with the problem of activity of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter, in gliomas. It has been shown that GABA has an antitumor activity in most models and cancer patients have an increased level of GABA ...
A. V. Kartashev, V. B. Voitenkov
doaj  

Advances in Parahydrogen‐Induced Polarization for Nuclear Magnetic Resonance of Peptides, Proteins, and Biopolymers

ChemistryEurope, EarlyView.
Hyperpolarization by parahydrogen‐induced polarization enhances the sensitivity of nuclear magnetic resonance spectroscopy of amino acids, peptides, mini‐proteins, and biopolymers using nonnatural amino acids with unsaturated side chains up to three orders of magnitude.
Gerd Buntkowsky
wiley   +1 more source

Detection of acetylcholinesterase activity and gamma-aminobutyric acid binding sites in Dicrocoelium dendriticum

Parasite, 2000
In the present study we report the presence of acetylcholinesterase activity and gamma-aminobutyric acid binding sites in crude extracts of Dicrocoelium dendriticum. This indirectly demonstrates the presence of acetylcholine and GABA.
Giménez-Pardo C., Ros-Moreno R.M., Armas-Serra C.De., Rodriguez-Caabeiro F.   +3 more
doaj   +1 more source

Development of tCAP(N3): Affinity Peptide‐Aided, pH‐Triggered Strategy for Site‐Specific Native IgG Modification

Chemistry – A European Journal, EarlyView.
The tCAP(N3) reagent, featuring a stable and self‐activating precursor, enables site‐specific conjugation of native IgGs. This Fc‐affinity peptide approach selectively transfers an Ac‐Lys(N3)‐Gly‐Gly payload to Lys248, producing divalently azidated antibody while preserving its biological function.
Hiroko Kawakami, Abdur Rafique, Shugo Tsuda, Asaki Nagashima, Yukie Nohara, Naoki Dozono, Ken Sakamoto, Shun Masuda, Masato Kiyoshi, Hiroko Shibata, Akiko Ishii‐Watabe, Taku Yoshiya, Yuji Ito   +12 more
wiley   +1 more source

Enhancement of Antioxidant Activity and Bioactive Compounds in Soy Whey Fermented with Lactiplantibacillus plantarum and Weissella confusa [PDF]

مجله پژوهش‌های علوم و صنایع غذایی ایران
Soy whey (SW) is a byproduct from tofu and soy protein isolate (SPI) production that contains various nutrients such as protein, amino acids, minerals, carbohydrates, isoflavones.
Shadi Atashgahi, Ali Moayedi, Alireza Sadeghi Mahoonak, Hoda Shahiri Tabarestani, Alireza Sadeghi   +4 more
doaj   +1 more source

Crossed cerebellar diaschisis in status epilepticus: A systematic review of the literature

Epileptic Disorders, EarlyView.
Abstract Objective Crossed cerebellar diaschisis is a neuroimaging phenomenon observed in various neurological conditions, including status epilepticus. This systematic review aims to summarize the clinical and radiological characteristics of patients developing crossed cerebellar diaschisis following status epilepticus and to discuss potential ...
Payam Tabaee Damavandi, Pilar Bosque‐Varela, Helena Barbosa Horta Santos, Bassam Al‐Fatly, Lukas Machegger, Eugen Trinka, Giorgi Kuchukhidze   +6 more
wiley   +1 more source