Results 61 to 70 of about 131,516 (182)

Synergy of piracetam and aminalon in the cerebroprotective effect of olatropyl.

Medičnì Perspektivi, 2018
Optimization of pharmacotherapy of neurological and psychosomatic diseases led to the creation of com­bined medicines containing two or more components with different mechanisms of action, differently affecting the pathogenesis and clinical ...
V. I. Mamchur, S. N. Dronov
doaj   +1 more source

Developmental changes in gamma-aminobutyric acid levels in attention-deficit/hyperactivity disorder

Translational Psychiatry, 2015
While the neurobiological basis and developmental course of attention-deficit/hyperactivity disorder (ADHD) have not yet been fully established, an imbalance between inhibitory/excitatory neurotransmitters is thought to have an important role in the ...
S. Bollmann, C. Ghisleni, Simon-Shlomo Poil, E. Martin, Joseph A. Ball, D. Eich-Höchli, R. Edden, P. Klaver, L. Michels, D. Brandeis, R. O'Gorman   +10 more
semanticscholar   +1 more source

Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. [PDF]

, 2018
There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABAA-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models.
Dang, Hoa, Kaufman, Daniel L, Olsen, Richard, Tian, Jide, Wallner, Martin   +4 more
core   +3 more sources

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

Neural Regeneration Research
Pain is often comorbid with emotional disorders such as anxiety and depression. Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric
Lu Guan, Mengting Qiu, Na Li, Zhengxiang Zhou, Ru Ye, Liyan Zhong, Yashuang Xu, Junhui Ren, Yi Liang, Xiaomei Shao, Jianqiao Fang, Junfan Fang, Junying Du   +12 more
doaj   +1 more source

Efficient gamma-aminobutyric acid bioconversion by engineered Escherichia coli

Biotechnology & Biotechnological Equipment, 2018
Gamma-aminobutyric acid (GABA) can be converted into 2-pyrrolidone, an intermediate in the synthesis of nylon 4 and agrochemicals, which has great potential for application in the chemical industry. The main aim of this work was to construct a simple and
Chongrong Ke, Jie Wei, Yang Ren, Xinwei Yang, Jia Chen, Jianzhong Huang   +5 more
doaj   +1 more source

Temporal coding at the immature depolarizing GABAergic synapse

Frontiers in Cellular Neuroscience, 2010
In the developing hippocampus, GABA exerts depolarizing and excitatory actions and contributes to the generation of neuronal network driven Giant Depolarizing Potentials (GDPs).
Guzel Valeeva, Guzel Valeeva, Azat Abdullin, Azat Abdullin, Azat Abdullin, Roman Tyzio, Andrei Skorinkin, Evgeny Nikolski, Yehezkiel Ben-Ari, Rustem Khazipov   +9 more
doaj   +1 more source

Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.

Sleep, 2014
STUDY OBJECTIVES To test if posttraumatic stress disorder (PTSD) is associated with low brain gamma-aminobutyric acid (GABA) levels and if reduced GABA is mediated by poor sleep quality.
D. Meyerhoff, A. Mon, T. Metzler, T. Neylan   +3 more
semanticscholar   +1 more source

Multiple functional neurosteroid binding sites on GABAA receptors [PDF]

, 2019
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav, Bracamontes, John R, Budelier, Melissa M, Chen, Zi-Wei, Cheng, Wayland W. L., Covey, Douglas F, Evers, Alex S, Germann, Allison L, Kathiresan, Krishnan, Manion, Brad, Qian, Ming-Xing, Reichert, David E, Shin, Daniel J   +12 more
core   +3 more sources

GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections

Nature Communications, 2018
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in neuronal systems, but the potential role for such neurotransmitters on the immune system are emerging.
Jin Kyung Kim, Yi Sak Kim, Hye-Mi Lee, Hyo Sun Jin, Chiranjivi Neupane, Sup Kim, Sang-Hee Lee, Jung-Joon Min, Miwa Sasai, Jae-Ho Jeong, Seong-Kyu Choe, Jin-Man Kim, Masahiro Yamamoto, Hyon E. Choy, Jin Bong Park, Eun-Kyeong Jo   +15 more
doaj   +1 more source

Prebiotic Organic Microstructures [PDF]

, 2011
Micro- and sub-micrometer spheres, tubules and fiber-filament soft structures have been synthesized in our experiments conducted with 3 MeV proton irradiations of a mixture of simple inorganic constituents, CO, N2 and H2O.
A Yoshihara, AM Hessler, CJ Hale, DI Foustoukos, F Klein, H Kurihara, J Takahashi, K Kobayashi, K Kobayashi, K Kobayashi, K Kobayashi, K Kvenvolden, Kensei Kobayashi, M Yoshizaki, Marie-Paule Bassez, MP Bassez, MP Bassez, O Botta, S Miyakawa, SL Seewald, T McCollom, T McCollom, Y Takano, Y Takano, Y Takano, Y Takano, Yoshinori Takano   +26 more
core   +2 more sources