Results 61 to 70 of about 93,041 (352)
Arthritis Care &Research, EarlyView.As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox +3 more
wiley +1 more source
Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]
, 2014 Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J +2 more
core +1 more source
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
Applied Food Biotechnology, 2022 Background and Objective: Gamma aminobutyric acid (GABA) is a non-protein amino acid with various physiological properties that is used as synthetic drugs for curing anxiety, acute stress, and hypertension.
Ali Moayedi +3 more
doaj +1 more source
Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. [PDF]
, 2012 Tetramethylenedisulfotetramine (TETS) is a potent convulsant that is considered a chemical threat agent. We characterized TETS as an activator of spontaneous Ca²⁺ oscillations and electrical burst discharges in mouse hippocampal neuronal cultures at 13 ...
Cao, Zhengyu +5 more
core +2 more sources
A Neuransistor with Excitatory and Inhibitory Neuronal Behaviors for Liquid State Machine
Advanced Materials, EarlyView.The neuransistor integrates hybrid excitatory and inhibitory dynamics, enabling liquid state machine implementation. It operates via charge trapping in a two‐dimensional electron electron gas (2DEG)/TiO2−x structure and features a three‐terminal design for efficient masking functionality. Simulations demonstrate its effectiveness in predicting temporal
Woon Hyung Cheong +6 more
wiley +1 more source
THYMOL ESTER OF GAMMA-AMINOBUTYRIC ACID: SYNTHESIS AND ANTICONVULSANT ACTIVITY
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, 2015 Thymol ester of gamma-aminobutyric acid (GABA) − 2-isopropyl-5-methylphenyl 4-aminobutyrate hydrochloride − was synthesized via Steglich esterification and characterized by 1H NMR, IR and mass spectral studies.
M. V. Nesterkina, I. A. Kravchenko
doaj +1 more source
Disrupted GABAergic facilitation of working memory performance in people with schizophrenia. [PDF]
, 2020 ObjectivesGamma-Amiobutyric acid (GABA) is a primary inhibitory neurotransmitter that facilitates neural oscillations that coordinate neural activity between brain networks to facilitate cognition.
Carter, CS +7 more
core
Geometric-algebraic approach to aqueous solutions of diprotic acids and its buffer mixtures [PDF]
arXiv, 2023 A closed-form analytical expression for $\ce{[H3O+]}$ has been obtained for aqueous solutions of diprotic acids and its soluble salts. This formula allows to calculate the pH of aqueous solutions of diprotic acids, their buffer solutions, and the titrations of these two by a strong base, from the values of p$K_1$, p$K_2$, and the effective ...
arxiv
Advanced Science, EarlyView.Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang +4 more
wiley +1 more source