Results 241 to 250 of about 95,987 (292)
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Nature Reviews Clinical Oncology, 2009
Peripheral T-cell lymphomas (TCLs) are uncommon neoplasms, accounting for about 12% of all lymphoid tumors worldwide. TCLs in which gammadelta T-cell receptors are expressed (gammadelta TCLs) are extremely aggressive and rare (
TRIPODO, Claudio +6 more
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Peripheral T-cell lymphomas (TCLs) are uncommon neoplasms, accounting for about 12% of all lymphoid tumors worldwide. TCLs in which gammadelta T-cell receptors are expressed (gammadelta TCLs) are extremely aggressive and rare (
TRIPODO, Claudio +6 more
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Clinical and Applied Immunology Reviews, 2003
Abstract Protection from exogenous invaders and elimination of endogenous aberrations are the main contributions of T cells to homeostasis. T cells with Vγ9Vδ2-encoded T-cell receptors (TCRs) have a unique ability to interact with a plethora of phosphoantigens in a major histocompatibility complex (MHC)-unrestricted manner. The biological function of
Miroslav Malkovsky +8 more
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Abstract Protection from exogenous invaders and elimination of endogenous aberrations are the main contributions of T cells to homeostasis. T cells with Vγ9Vδ2-encoded T-cell receptors (TCRs) have a unique ability to interact with a plethora of phosphoantigens in a major histocompatibility complex (MHC)-unrestricted manner. The biological function of
Miroslav Malkovsky +8 more
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Evidence for clonal selection of gamma/delta T cells in response to a human pathogen. [PDF]
Journal of Experimental Medicine, 1991 T cells bearing gamma/delta antigen receptors comprise a resident population of intraepithelial lymphocytes in organs such as skin, gut, and lungs, where they are strategically located to contribute to the initial defense against infection.
K Uyemura, H Band, Craig T Morita
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Peptide antigens for gamma/delta T cells
Cellular and Molecular Life Sciences, 2011γδ T cells express adaptive antigen receptors encoded by rearranging genes. Their diversity is highest in the small region of TCR V-J junctions, especially in the δ chain, which should enable the γδ TCRs to distinguish differences in small epitopes.
Willi K, Born +7 more
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Hepatosplenic gamma-delta T-cell lymphoma
Critical Reviews in Oncology/Hematology, 2012Hepatosplenic T-cell lymphoma (HSTL) is a rare and aggressive extranodal lymphoma derived mostly from cytotoxic γδ T-cells. The peak incidence is in adolescents and young adults, and is more common in males. Up to 20% of HSTL arise in the setting of chronic immune suppression, most commonly solid organ transplantation or prolonged antigenic stimulation.
Ferreri AJ, Govi S, PILERI, STEFANO
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Gamma Delta T Cell Function in Ruminants
Veterinary Clinics of North America: Food Animal Practice, 2019Gamma delta (γδ) T cells constitute a major lymphocyte population in peripheral blood and epithelial surfaces. They play nonredundant roles in host defense against diverse pathogens. Although γδ T cells share functional features with other cells of the immune system, their distinct methods of antigen recognition, rapid response, and tissue tropism make
Mariana, Guerra-Maupome +2 more
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Mesenchymal cells inhibit expansion but not cytotoxicity exerted by gamma–delta T cells
European Journal of Clinical Investigation, 2009 Background Multipotent mesenchymal stromal cells (MSCs) exert a relevant immunosuppressive activity by inhibiting T- and B-lymphocytes, natural killer (NK) cells and dendritic cell expansion.
Iacopo Petrini +2 more
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2001
T cell receptor and function cosegregate in gamma-delta T Cell subsets, R.L. O'Brien, M. Lahn, W.K. Born, et al role of the IL-7 receptor in gamma-delta T cell development, K. Ikuta, H.-C. Lee, S.-K. Ye epidermal and dermal gamma-delta T cells, K. Tamaki, M. Sugaya, Y.
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T cell receptor and function cosegregate in gamma-delta T Cell subsets, R.L. O'Brien, M. Lahn, W.K. Born, et al role of the IL-7 receptor in gamma-delta T cell development, K. Ikuta, H.-C. Lee, S.-K. Ye epidermal and dermal gamma-delta T cells, K. Tamaki, M. Sugaya, Y.
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Lifespan of gamma/delta T cells.
The Journal of experimental medicine, 1998Information on the turnover and lifespan of murine gamma/delta cells was obtained by administering the DNA precursor, bromodeoxyuridine (BrdU), in the drinking water and staining lymphoid cells for BrdU incorporation. For TCR-gamma/delta (Vgamma2) transgenic mice, nearly all gamma/delta thymocytes became BrdU+ within 2 d and were released rapidly into ...
D F, Tough, J, Sprent
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Gamma-Delta T Cells in the Skin
2017The skin forms the body’s primary interface with the environment and, as such, is equipped with a network of immune cells to provide the first line of defence against infection and injury. While the role of conventional alpha-beta (αβ) T cell receptor (TCR) expressing lymphocytes in skin homeostasis and pathology has been studied in great detail ...
Sioh-Yang Tan +4 more
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