Results 61 to 70 of about 9,031 (203)

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Plant-derived anticancer agents: Lessons from the pharmacology of geniposide and its aglycone, genipin [PDF]

, 2018
For centuries, plants have been exploited by mankind as sources of numerous cancer chemotherapeutic agents. Good examples of anticancer compounds of clinical significance today include the taxanes (e.g., taxol), vincristine, vinblastine, and the ...
Berthiaume, Butler, Cheng, Lau, Lee, Nakayachi, Sánchez-Medina, Wang, Yang, Yao, Zhang   +10 more
core   +2 more sources

From Gene to Enzyme: Multidimensional Decoding of the GGT Molecular Family and Its Clinical Tumor Diagnosis

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Gamma‐glutamyltransferase (GGT) is a membrane‐bound enzyme involved in glutathione metabolism and oxidative stress regulation. Although it is traditionally viewed as a liver function marker, emerging evidence suggests that its aberrant expression is closely associated with tumorigenesis, progression, and therapeutic resistance ...
Fei Wang, Jianshan Yang, Feng Zhu, Xuebing Xu, Junpeng Zhao, Xudong Xie, Xuyang He, Yuxuan Huang, Lirong Zhou, Xiaogang Hu, Xiaomin Lu, Mingbing Xiao   +11 more
wiley   +1 more source

Metabolic Functions and Mechanisms of Selenium, Selenocysteine, and GPX4 Mediated Immune Regulation Through Autophagy in Solid Tumors

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This paper focuses on selenium, selenocysteine, and GPX4, elaborating on their metabolic functions and mechanisms in mediating immune regulation through autophagy in solid tumors. It explores the characteristics of selenium metabolism in tumors and the roles of related enzymes, providing new directions for cancer treatment.
Liang Yang, Yu Jiang, Haoyue Wu, Jinnan Sun, Xinyue Huang, Jingfeng Hong, Bin Zheng, Jinmiao Zhu   +7 more
wiley   +1 more source

Progression and Metastasis of Lung Cancer: Clinical Features, Molecular Mechanisms, and Clinical Managements

MedComm, Volume 6, Issue 12, December 2025.
Lung cancer represents a significant global health threat. Despite progress in treatment, metastasis continues to present a major clinical challenge. This article reviews the metastases of lung cancer to the liver, bone, and brain, focusing on clinical symptoms, molecular mechanisms, and treatment strategies.
Yunkui Zhang, Meixi Chen, Xumeng Fang, Yu Han, Yingke Li   +4 more
wiley   +1 more source

Development and validation of chromatographic methods to study folate derivatives produced by yeasts [PDF]

, 2007
Folate, or folic acid, is an important water soluble B vitamin that exists in many different forms. Its presence is necessary for synthesis of DNA and RNA and methylation of homocysteine to methionine.
Patring, Johan
core  

Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity:Implications for atopic dermatitis [PDF]

, 2018
Background: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products [natural moisturizing factors (NMFs ...
Barrett, Bartnikas, Breternitz, Brough, Brown, Carson, Chittock, Clements, Dapic, DeLapp, Fallon, Fluhr, Gibbs, Halkjaer, Hoath, Horimukai, Hsu, Irvine, Kamata, Kamata, Kashibuchi, Kelleher, Kennedy, Kuroda, Ludriksone, McAleer, Mohammed, Mohammed, Raj, Raj, Rawlings, Sandilands, Sandilands, Schwartz, Scott, Simpson, Stamatas, Stamatas, Strid, Strid, Tagami, Takahashi, Takeda, Takeda, Visscher, Voegeli, Voegeli, Weidinger, Yamamoto, Yamazaki   +49 more
core   +3 more sources

γ-Glutamyl Hydrolase, Not Glutamate Carboxypeptidase II, Hydrolyzes Dietary Folate in Rat Small Intestine [PDF]

The Journal of Nutrition, 2007
Dietary polyglutamyl folates are hydrolyzed to monoglutamyl folate derivatives prior to intestinal transport. In humans and pigs, the reaction occurs at pH 6.5 at the jejunal brush border membrane by folate hydrolase and is encoded by the glutamate carboxypeptidase II (GCPII) gene.
Tracy B, Shafizadeh, Charles H, Halsted
openaire   +2 more sources

Unveiling the Potential of Lentilactobacillus hilgardii in Malolactic Fermentation: Comparative Genomics and Fermentation Dynamics

Microbial Biotechnology, Volume 18, Issue 12, December 2025.
This study explores the metabolic potential of Lentilactobacillus hilgardii for malolactic fermentation in winemaking. Genomic and in silico analyses, combined with experimental validation, reveal its resilience at low temperatures and unique enzymatic traits. Comparative insights with Oenococcus oeni highlight L.
Giacomo Mantegazza, Nicola Mangieri, Elnaz Vojoudi Yazdi, Pasquale Russo, Diego Mora, Giorgio Gargari   +5 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source