Results 81 to 90 of about 9,031 (203)

Prediction of Methotrexate toxicity in Algerian Rheumatoid Arthritis Patients: Implication of GGH rs11545078 polymorphism

Journal de la Faculté de Médecine d'Oran
Objectives - The aim of this study is to determine the impact of the gamma glutamyl hydrolase (GGH) c.452C>T (dbSNP Id: rs 11545078) polymorphism on the Methotrexate (MTX) adverse drug reactions (ADRs) and on MTX gastro intestinal toxicity (GIT) in ...
Wefa Boughrara, Ahmed Benzaoui, Meriem Aberkane, Fatima Zohra Moghtit, Samia Dorgham, Abdellah Boudjema   +5 more
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Global transcriptome response in during growth on ribose [PDF]

, 2011
Background Lactobacillus sakei is valuable in the fermentation of meat products and exhibits properties that allow for better preservation of meat and fish. On these substrates, glucose and ribose are the main carbon sources available for growth. We used
Naterstad Kristine, Snipen Lars, McLeod Anette, Axelsson Lars   +3 more
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Widespread impact of horizontal gene transfer on plant colonization of land [PDF]

, 2012
In complex multicellular eukaryotes such as animals and plants, horizontal gene transfer is commonly considered rare with very limited evolutionary significance.
A Schaller, AA Wiszniewski, AK Werner, AO Richardson, B Wang, B Zhu, C Esser, C Zhao, D Cove, D Pisani, DC Price, EG Danchin, G Emiliani, G Noctor, G Ricard, G Sun, G Sun, H Ochman, H Philippe, H Tanaka, HA Schmidt, J Huang, J Huang, J Huang, JD Hackett, JO Andersson, JO Andersson, JO Andersson, JO Andersson, JP Gogarten, L Belbahri, L Klasson, LE Graham, LW Neuteboom, M Koulintchenko, M Syvanen, MC Brundrett, MJ Sanderson, NA Moran, PA Christin, PJ Keeling, R Alcazar, R Bock, S Guindon, S Yoshida, SD Copley, T Davidsen, T Flores, T Kusano, T Ni, TA Richards, TM Keane, U Bergthorsson, VV Goremykin, W Martin, Y Cheng   +55 more
core   +1 more source

Folate Network Genetic Variation, Plasma Homocysteine, and Global Genomic Methylation Content: A Genetic Association Study [PDF]

, 2013
Background: Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease.
Baccarelli, Andrea, Bollati, Valentina, Cassano, Patricia A, Clark, Andrew G., Gaziano, John Michael, Litonjua, Augusto Ampil, Schwartz, Joel David, Stover, Patrick J, Tucker, Katherine L, Weiss, Scott Tillman, Wells, Martin T, Wernimont, Susan M   +11 more
core   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias.

Oncology research, 1997
Decreased methotrexate (MTX) long-chain polyglutamate formation is associated with MTX resistance whereas high levels of MTX polyglutamate accumulation are found in the blasts of leukemia patients who respond to therapy and have improved outcome. The steady-state level of long-chain MTX polyglutamates depends on the balance of activities of two enzymes:
G S, Longo, R, Gorlick, W P, Tong, S, Lin, P, Steinherz, J R, Bertino   +5 more
openaire   +1 more source

Método para reconstrução in silico de redes metabólicas de fungos : um estudo de caso para o Paracoccidioides lutzii [PDF]

, 2014
Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Exatas, Departamento de Ciência da Computação, 2014.Os fungos produzem uma variedade de metabólitos com aplicações na indústria e na medicina, ao mesmo tempo que podem ser patógenos ...
Silva, Waldeyr Mendes Cordeiro da
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Knocking down 10-formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement [PDF]

[[incitationindex ...
[[corresponding]]Fu TF, Chang WN, Lee GH, Kao TT, Lin CY, Hsiao TH, Tsai JN, Chen BH, Chen YH, Wu HR, Tsai HJ, Fu TF   +1 more
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Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate.

The Journal of biological chemistry, 2002
gamma-Glutamyl hydrolase catalyzes the cleavage of the gamma-glutamyl chain of folylpoly-gamma-glutamyl substrates and is a central enzyme in folyl and antifolyl poly-gamma-glutamate metabolism. The crystal structure of human gamma-glutamyl hydrolase, determined at 1.6-A resolution, reveals that the protein is a homodimer.
Hongmin, Li, Thomas J, Ryan, Karen J, Chave, Patrick, Van Roey   +3 more
openaire   +1 more source

Secretoma do fungo biocontrolador Metarhizium anisopliae relacionado à infecção do carrapato bovino Rhipicephalus microplus [PDF]

, 2016
O controle biológico é considerado uma alternativa natural e ecológica para o controle de pragas, evitando os problemas causados pela utilização de agentes químicos.
Scherer, Karine
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