Results 91 to 100 of about 12,504 (230)
Advanced Science, Volume 13, Issue 8, 9 February 2026.The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai +7 more
wiley +1 more source
CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target
Advanced Science, Volume 13, Issue 8, 9 February 2026.This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang +2 more
wiley +1 more source
P1‐028: Gamma—secretase modulators do not show a potency shift in high expressing model systems [PDF]
, 2011 Brian S. Bronk +6 more
openalex +1 more source
Advanced Science, Volume 13, Issue 9, 13 February 2026.This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang +5 more
wiley +1 more source
Figure S1 from Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma [PDF]
, 2023 Katherine M. Morgan +8 more
openalex +2 more sources
Folate deprivation increases presenilin expression, gamma‐secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S‐adenosyl methionine [PDF]
, 2007 Amy Chan, Thomas B. Shea
openalex +1 more source
Antibody‐Empowered Nanomedicine for Precise Biomedical Applications
Advanced Science, Volume 13, Issue 10, 18 February 2026.This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen +7 more
wiley +1 more source
Targeting gamma secretase: has progress moved up a Notch? [PDF]
, 2018 Ecaterina E. Dumbrava +2 more
openalex +1 more source
Advanced Science, Volume 13, Issue 12, 27 February 2026.Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély +5 more
wiley +1 more source