Results 171 to 180 of about 12,504 (230)

P2‐461: Selective modulation of gamma‐secretase cleavage of the amyloid precursor family of proteins [PDF]

, 2008
Carlo Sala Frigerio, Thomas Kukar, Pamela Osenkowski, Paul C. Engel, Michael S. Wolfe, Todd E. Golde, Dominic M. Walsh   +6 more
openalex   +1 more source

Additional file 1 of PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia

, 2021
Inge Govaerts, Cristina Prieto, Charlien Vandersmissen, Olga Gielen, Kris Jacobs, Sarah Provost, David Nittner, Johan Maertens, Nancy Boeckx, Kim De Keersmaecker, Heidi Segers, Jan Cools   +11 more
openalex   +1 more source

A novel generation of potent gamma-secretase modulators: Combat Alzheimer's disease and Down syndrome-associated Alzheimer's disease. [PDF]

Neural Regen Res
Chen XQ.
europepmc   +1 more source

Allogeneic Anti-BCMA CAR T Cells Are Superior to Multiple Myeloma-derived CAR T Cells in Preclinical Studies and May Be Combined with Gamma Secretase Inhibitors. [PDF]

Cancer Res Commun, 2022
Metelo AM, Jozwik A, Luong LA, Dominey-Foy D, Graham C, Attwood C, Inam S, Dunlop A, Sanchez K, Cuthill K, Rice C, Streetly M, Bentley T, Boldajipour B, Sommer C, Sasu B, Benjamin R.   +16 more
europepmc   +1 more source

PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease. [PDF]

Acta Neuropathol Commun
Perrin F, Anderson LC, Mitchell SPC, Sinha P, Turchyna Y, Maesako M, Houser MCQ, Zhang C, Wagner SL, Tanzi RE, Berezovska O.   +10 more
europepmc   +1 more source

Use of an Intramolecular Quenched Fluorescence (IQF) Cleavage Assay for Assessing Enzyme Kinetics of Gamma-Secretase in Human Skin Fibroblasts and Keratinocytes. [PDF]

Methods Mol Biol
Badiei B, Garza LA.
europepmc   +1 more source

Supporting data for the effect of gamma-secretase inhibitors in osteoclast differentiation and spreading

, 2016
Won Jong Jin, Bong-Jun Kim, Jung‐Wook Kim, Hong‐Hee Kim, Hyunil Ha, Zang Hee Lee   +5 more
openalex   +1 more source

Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates. [PDF]

J Exp Med, 2020
Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C.   +14 more
europepmc   +1 more source

Molecular understanding of a rat model with schizophrenia-related features. Gene-dosage imbalance of the gamma-secretase component Aph-1b in APO-SUS and -UNSUS rats

, 2006
Marcellus Wilhelmus. Coolen
openalex   +1 more source

Investigating Complex Formation of C99 with Gamma-Secretase, Using Atomistic MM-MD Simulations and Free Energy Calculations [PDF]

, 2018
Manuel Hitzenberger, Martin Zacharias
openalex   +1 more source