Results 171 to 180 of about 11,895 (194)

Presenilin function and gamma-secretase activity.

Journal of neurochemistry, 2005
Alzheimer's disease (AD) is the most common form of dementia and is characterized pathologically by the accumulation of beta-amyloid (Abeta) plaques and neurofibrillary tangles in the brain. Genetic studies of AD first highlighted the importance of the presenilins (PS).
A L, Brunkan, A M, Goate
openaire   +1 more source

Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer’s disease

Cell Reports, 2021
Jonghee Han, Yoonseo Oh, Youbin Kim
exaly  

Gamma Secretase

2007
Sharie Haugabook, Kumar Sambamurti
openaire   +1 more source

Gamma-secretase inhibitors and Alzheimer's disease.

Advanced drug delivery reviews, 2003
The existence of pathogenic mutations in beta-APP and the presenilin genes provides strong support for the hypothesis that Abeta production and deposition contribute to the etiology of Alzheimer's disease (AD). The heterogeneous carboxyl termini of Abeta molecules deposited in the hippocampus, cortex and cerebrovasculature of AD patients are generated ...
openaire   +1 more source

Gamma-Secretase (Complex)

2005
openaire   +2 more sources

Gamma-Secretase (Complex)

2011
openaire   +2 more sources

Gamma Secretase-Activating Protein Is a Substrate for Caspase-3: Implications for Alzheimer’s Disease

Biological Psychiatry, 2015
Jin Chu, Yash B Joshi, Phillip F Giannopoulos   +2 more
exaly  

Complex regulation of γ-secretase: from obligatory to modulatory subunits

Frontiers in Aging Neuroscience, 2015
Yue-Ming Li, Li Yueming
exaly  

Gamma secretase inhibitors: a patent review (2013 - 2015)

Expert Opinion on Therapeutic Patents, 2017
Hongzhi Lin, Siyu He, Haopeng Sun
exaly  

Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings

Current Medical Research and Opinion, 2014
David B Henley, Gopalan Sethuraman, Sherie A Dowsett   +2 more
exaly