Results 211 to 220 of about 12,504 (230)
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Advances in gamma-secretase modulation.
Current opinion in drug discovery & development, 2007Inhibition of the production of insoluble amyloid-Beta (ABeta) is a widely pursued strategy for the treatment of Alzheimer's disease (AD). The final step in the generation of ABeta from the amyloid precursor protein (APP) involves cleavage by gamma-secretase, and gamma-secretase inhibitors (GSIs) have been shown to reduce the amyloid burden in animal ...
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Presenilin function and gamma-secretase activity.
Journal of neurochemistry, 2005Alzheimer's disease (AD) is the most common form of dementia and is characterized pathologically by the accumulation of beta-amyloid (Abeta) plaques and neurofibrillary tangles in the brain. Genetic studies of AD first highlighted the importance of the presenilins (PS).
A L, Brunkan, A M, Goate
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Development of Specific Gamma Secretase Inhibitors
2009Secretases are aspartic proteases, which specifically trim important, medically relevant targets such as the amyloid-precursor protein (APP) or the Notch-receptor. Therefore, changes in their activity can lead to dramatic diseases like M. Alzheimer caused by aggregation of peptidic fragments.
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Identity and function of gamma-secretase.
Journal of neuroscience research, 2003gamma-Secretase catalyzes intramembrane proteolysis of various type I membrane proteins, including the amyloid-beta precursor protein and the Notch receptor. Despite its importance in the pathogenesis of Alzheimer's disease and to normal development, this protease has eluded identification until only very recently.
W Taylor, Kimberly, Michael S, Wolfe
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Gamma-secretase inhibitors and Alzheimer's disease.
Advanced drug delivery reviews, 2003The existence of pathogenic mutations in beta-APP and the presenilin genes provides strong support for the hypothesis that Abeta production and deposition contribute to the etiology of Alzheimer's disease (AD). The heterogeneous carboxyl termini of Abeta molecules deposited in the hippocampus, cortex and cerebrovasculature of AD patients are generated ...
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gamma-Secretase in biology and medicine.
Seminars in cell & developmental biology, 2009gamma-Secretase is a membrane-embedded proteolytic complex composed of presenilin and three other subunits. The gamma-secretase complex generates the amyloid beta-peptide of Alzheimer's disease but also plays important roles in normal physiology, especially in signaling from the Notch receptor.
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MUC1 is a substrate for gamma-secretase.
Journal of cellular biochemistry, 2010Understanding the underlying mechanisms by which a normal cell avoids the oncogenic potential of MUC1 signaling requires further definition of the pathways by which the MUC1 cytoplasmic tail is processed in both normal and tumor-derived cells. In the present study we describe the processing pathway initiated by TACE/ADAM17 cleavage of MUC1.
Joanne, Julian +2 more
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[Gamma-secretase inhibitors in Alzheimer's disease therapy].
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2012Neuritic plaques, which are situated in the brain of Alzheimer's disease (AD) patients, are composed mainly of peptides containing 40 or 42 amino acid residues known as ß-amyloid plaques (Aß). The Aß peptide is the result of the enzymatic cleavage of the amyloid precursor protein (APP).
Spilovská, Katarína +3 more
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