Epithelial-mesenchymal transition as a potential route for DAPT resistance in breast cancer cells
Türk Biyokimya Dergisi, 2023 Notch is a conserved pathway involved in cell-fate determination and homeostasis. Its dysregulation plays a role in poor prognosis and drug resistance in breast cancer.
Telli Kubra, Yalcin-Ozuysal Ozden
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PLoS ONE, 2012 The gamma-secretase complex is involved in the intramembranous proteolysis of a variety of substrates, including the amyloid precursor protein and the Notch receptor.
Jung-Soon Mo +10 more
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Neuronal apoptosis and synaptic density in the dentate gyrus of ischemic rats' response to chronic mild stress and the effects of Notch signaling. [PDF]
PLoS ONE, 2012 Our previous research highlighted an inconsistency with Notch1 signaling-related compensatory neurogenesis after chronic mild stress (CMS) in rodents suffering from cerebral ischemia, which continue to display post-stroke depressive symptoms.
Shaohua Wang +6 more
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Presenilins and γ-Secretase in Membrane Proteostasis
Cells, 2019 The presenilin (PS) proteins exert a crucial role in the pathogenesis of Alzheimer disease (AD) by mediating the intramembranous cleavage of amyloid precursor protein (APP) and the generation of amyloid β-protein (Aβ).
Naoto Oikawa, Jochen Walter
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Effect of Eight Weeks of Positive Slope and Negative Slope Training, Along with Royal Jelly on The Hippocampal Expression Of Β- Amyloid And Γ-Secretase in Trimethyltin-Induced Alzheimer's Disease Rats [PDF]
Journal of Fasting and Health, 2021 Introduction: One of the main causes of Alzheimer's disease is an increase in amyloid-beta (Aβ) peptides, which are produced by the activity of the enzyme gamma-secretase (γ-secretase). Although exercise and the use of royal jelly have protective effects
Zahra Giti +3 more
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Gamma secretase inhibitors of Notch signaling
OncoTargets and Therapy, 2013 The numerous processes involved in the etiology of breast cancer such as cell survival, metabolism, proliferation, differentiation, and angiogenesis are currently being elucidated. However, underlying mechanisms that drive breast cancer progression and drug resistance are still poorly understood.
Osipo, Clodia +2 more
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Presenilin/γ-secretase and inflammation
Frontiers in Aging Neuroscience, 2010 Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins.
Carlos A Saura
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Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. [PDF]
PLoS Biology, 2008 The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP)
LiMei Wang +8 more
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Indian Journal of Dermatology, 2023 Background: Hidradenitis suppurativa (HS) is a complex, chronic inflammatory skin disorder whose pathophysiology is poorly understood. Genetic studies have shown that HS is predisposed by mutations in the γ-secretase gene, but only a proportion of ...
Uppala Ratnamala +6 more
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Intracellular pH regulates amyloid precursor protein intracellular domain accumulation
Neurobiology of Disease, 2007 The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux +8 more
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