Results 31 to 40 of about 11,895 (194)
Neuronal apoptosis and synaptic density in the dentate gyrus of ischemic rats' response to chronic mild stress and the effects of Notch signaling. [PDF]
PLoS ONE, 2012 Our previous research highlighted an inconsistency with Notch1 signaling-related compensatory neurogenesis after chronic mild stress (CMS) in rodents suffering from cerebral ischemia, which continue to display post-stroke depressive symptoms.
Shaohua Wang +6 more
doaj +1 more source
Gamma secretase inhibitors of Notch signaling
OncoTargets and Therapy, 2013 The numerous processes involved in the etiology of breast cancer such as cell survival, metabolism, proliferation, differentiation, and angiogenesis are currently being elucidated. However, underlying mechanisms that drive breast cancer progression and drug resistance are still poorly understood.
Olsauskas-Kuprys ,Roma +2 more
openaire +4 more sources
Presenilins and γ-Secretase in Membrane Proteostasis
Cells, 2019 The presenilin (PS) proteins exert a crucial role in the pathogenesis of Alzheimer disease (AD) by mediating the intramembranous cleavage of amyloid precursor protein (APP) and the generation of amyloid β-protein (Aβ).
Naoto Oikawa, Jochen Walter
doaj +1 more source
Presenilin/γ-secretase and inflammation
Frontiers in Aging Neuroscience, 2010 Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins.
Carlos A Saura
doaj +1 more source
Indian Journal of Dermatology, 2023 Background: Hidradenitis suppurativa (HS) is a complex, chronic inflammatory skin disorder whose pathophysiology is poorly understood. Genetic studies have shown that HS is predisposed by mutations in the γ-secretase gene, but only a proportion of ...
Uppala Ratnamala +6 more
doaj +1 more source
Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease [PDF]
International Journal of Alzheimer's Disease, 2012 The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD)—formation of amyloid plaques, neurofibrillary tangles, synaptic loss, neurodegeneration, and cognitive decline—are triggered by Aβpeptide dysregulation (Kakuda et al., 2006, Sato et al., 2003, Qi-Takahara et al., 2005).
Barbara Tate +12 more
openaire +2 more sources
Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. [PDF]
PLoS Biology, 2008 The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP)
LiMei Wang +8 more
doaj +1 more source
Intracellular pH regulates amyloid precursor protein intracellular domain accumulation
Neurobiology of Disease, 2007 The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux +8 more
doaj +1 more source
Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity. [PDF]
PLoS ONE, 2008 Presenilin1 (PS1) is a component of the gamma-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated.
Imma Raurell +6 more
doaj +1 more source
Biomedicines, 2022 Our studies reveal changes in the expression of the main participants in the processing of amyloid precursor protein (APP) in neurons and astrocytes after photothrombotic stroke (PTS). Here we show the increase in the level of N- and C-terminal fragments
Svetlana Sharifulina +10 more
doaj +1 more source