Results 71 to 80 of about 12,504 (230)

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and γ-secretase inhibitors

Haematologica, 2010
T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations and Notch can transcriptionally down-regulate the tumor suppressor PTEN.
Ana Silva, Patrícia Y. Jotta, André B. Silveira, Daniel Ribeiro, Silvia R. Brandalise, J. Andrés Yunes, João T. Barata   +6 more
doaj   +1 more source

Targeting the Notch receptor dimerization domain to inhibit Notch signalling—A new avenue of therapeutics

The FEBS Journal, EarlyView.
Notch signalling is an evolutionarily conserved signalling pathway that directs cell growth and differentiation across multiple tissue types, and its regulation must be controlled across the lifespan. Aberrant Notch signalling due to genetic mutations that occur within the negative regulatory region of the Notch 1 gene is linked to the development of ...
Gerard F Hoyne
wiley   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Figure S6 from Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma [PDF]

, 2023
Katherine M. Morgan, Bruce S. Fischer, Francis Y. Lee, Jamie J. Shah, Joseph R. Bertino, Jeffrey V. Rosenfeld, Amartya Singh, Hossein Khiabanian, Sharon R. Pine   +8 more
openalex   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Gamma Secretase Inhibitors in Cancer

International Journal of Trends in OncoScience
Gamma secretase inhibitors (GSIs), for Alzheimer's disease treatment, have been repurposed as anticancer agents because they inhibit receptor cleavage. Preclinical studies suggested that GSIs effectively promote the differentiation and apoptosis of cancer stem-like cells while obstructing epithelial-to-mesenchymal transition and increasing sensitivity ...
Dr. V. Aruna, Dr. Anand Mohan Jha, Dr Riffat A Fatima, Dr. Abikesh Prasada Kumar Mahapatra   +3 more
openaire   +1 more source

Novel NOTCH3 alteration expanding the molecular spectrum of pericytic tumours: report of two cases

Histopathology, Volume 88, Issue 4, Page 922-927, March 2026.
Introduction Myofibromas are part of the pericytic tumour family, which includes myopericytomas, glomus tumours and angioleiomyomas. While they typically display benign behaviour when arising in the skin and subcutaneous tissues of the head and neck, rare aggressive variants have been reported, particularly those with visceral or intracranial ...
Irena Antonia Ungureanu, Megane Le Quang, Rihab Azmani, Marie Ancelle, Henri Margot, Guillaume Chotard, François Le Loarer, Nathalène Truffaux   +7 more
wiley   +1 more source

Specific Lipid Peroxidation Products in Erythrocytes and Their Relationship to the Pathogenesis of Alzheimer's Disease

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Alzheimer's disease (AD) is a highly complex and multifactorial disorder in which oxidative stress acts as a key amplifying mechanism in the disease progression. Lipofuscin‐like pigments (LFP), end products of lipid peroxidation, reflect oxidative damage and are capable of crossing the blood–brain barrier into the circulation.
Lenka Martináková, Zuzana Chmátalová, Kateřina Veverová, Vanesa Jurášová, Alžběta Katonová, Martina Laczó, Jan Laczó, Martin Vyhnálek, Jakub Hort, Alice Skoumalová   +9 more
wiley   +1 more source

A Review of Current Computational Tools for Peptide–Protein Docking

Journal of Computational Chemistry, Volume 47, Issue 5, 15 February 2026.
In this review, we compare 14 specialized peptide‐protein docking programs, adaptable small‐molecule docking tools, and emerging AI‐driven approaches. By clarifying how each method works, we offer researchers an accessible guide to selecting the most suitable tools for biochemical studies and peptide‐focused drug discovery.
Fábio G. Martins, Hélder A. Santos, Sérgio F. Sousa   +2 more
wiley   +1 more source