Results 81 to 90 of about 2,375,747 (287)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Retomando o futuro: a reconstrução de si por meio de grupos de apoio = Retaking the future: rebuilding the self through support groups = Reanudar el futuro: reconstruirse a través de grupos de apoyo

Civitas - Revista de Ciências Sociais, 2022
Neste artigo, por meio de uma pesquisa qualitativa envolvendo observações e entrevistas, analiso dois “grupos de apoio” na cidade do Rio de Janeiro que assistem a pessoas que tiveram um grave contato com a morte, direta ou indiretamente.
Talone, Vittorio da Gamma
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Radiative Decays involving a0(980) and f0(980) in the Vector Meson Dominance Model [PDF]

, 2003
We summarize some features of the vector meson dominance model which was recently proposed for studying radiative decays involving the scalar mesons.
Black, Deirdre, Harada, Masayasu, Schechter, Joseph   +2 more
core   +2 more sources

Feasibility of Multiple Repeat Gamma Knife Radiosurgeries for Trigeminal Neuralgia: A Case Report and Review of the Literature

Case Reports in Medicine, 2011
Treatment options for trigeminal neuralgia (TN) must be customized for the individual patient, and physicians must be aware of the medical, surgical, and radiation treatment modalities to prescribe optimal treatment courses for specific patients.
Guy C. Jones, Ameer L. Elaimy, John J. Demakas, Hansi Jiang, Wayne T. Lamoreaux, Robert K. Fairbanks, Alexander R. Mackay, Barton S. Cooke, Christopher M. Lee   +8 more
doaj   +1 more source

Sensitivities on the anomalous quartic $$\gamma \gamma \gamma \gamma $$ and $$\gamma \gamma \gamma Z$$ couplings at the CLIC

The European Physical Journal C
AbstractIt is essential to directly investigate the self-couplings of gauge bosons in the Standard Model (SM) due to its non-Abelian nature, as these couplings play a significant role in comprehending the gauge structure of the model. The discrepancies between the Standard Model’s expectations and the measured value of gauge boson self-couplings serve ...
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Dysphagia, dysphonia & dyspnoe caused by ostrich beak-like anterior C1-C2 cervical osteophyte

Interdisciplinary Neurosurgery, 2019
Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is associated with cervical osteophytes, most commonly at the C5–6 level. We report a large beak-like anterior osteophyte at C1/C2 level presenting with severe dysphagia, dysphonia ...
Hardik Sardana, M.Ch., Hitesh Inder Singh Rai, MBBS, Amandeep Kumar, M.Ch., Deepak Agrawal, M.Ch., S.S. Kale, M.Ch.   +4 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source