Results 151 to 160 of about 22,547 (314)

New Insights Into Factors Shaping CMV‐Specific T‐Cell Polyfunctionality After Hematopoietic Cell Transplantation

open access: yesAmerican Journal of Hematology, Volume 101, Issue 2, Page 255-268, February 2026.
ABSTRACT Polyfunctional cytomegalovirus (CMV)‐specific T cells are critical for antiviral immunity in allogeneic hematopoietic cell transplantation (HCT) recipients. However, gaps remain in managing refractory CMV and optimizing virus‐specific cellular therapy (VST).
Alicja Sadowska‐Klasa   +9 more
wiley   +1 more source

Single‐cell analysis reveals cytotoxic and memory CD8+ T cells associated with prolonged survival in relapsed/refractory leukaemia patients after haplo+cord haematopoietic stem cell transplantation

open access: yesClinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. Haplo+cord HSCT yields superior survival compared with single cord HSCT in patients with R/R leukaemia. 2. Single‐cell RNA‐seq revealed a functionally critical CD8⁺ T cell population, with cytotoxic and memory phenotypes, which expands after haplo+cord HSCT and tracks with prolonged survival. 3. Multi‐omics profiling at single‐cell resolution showed
Hua Li   +18 more
wiley   +1 more source

Acute severe cholestatic hepatitis and lymphopenia characterize pediatric hepatitis‐associated aplastic anemia

open access: yesJournal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 374-382, February 2026.
Abstract Objectives Hepatitis‐associated aplastic anemia (HAAA) is described as acute severe hepatitis of unknown origin followed by bone marrow failure (BMF). We aimed to provide a comprehensive picture of pediatric HAAA. Methods Two‐center retrospective analysis was performed using data from children diagnosed with acquired BMF, including severe ...
Daniel Tegtmeyer   +8 more
wiley   +1 more source

Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Stem cells offer multifaceted therapeutic approaches for inflammatory diseases, each exhibiting distinct therapeutic properties. Hematopoietic stem cells, primarily through hematopoietic stem cell transplantation (HSCT), can effectively remodel the immune environment, showing particular promise in treating genetically linked cases.
Chen Wu   +4 more
wiley   +1 more source

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 515-528, February 2026.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper   +6 more
wiley   +1 more source

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