Results 171 to 180 of about 7,401 (195)
Control of Gammaherpesvirus Latency by Latent Antigen-Specific Cd8+ T Cells
Journal of Experimental Medicine, 2000 The contribution of the latent antigen-specific CD8(+) T cell response to the control of gammaherpesvirus latency is currently obscure. Some latent antigens induce potent T cell responses, but little is known about their induction or the role they play ...
Edward J Usherwood +2 more
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Pathogenesis of gammaherpesvirus infections
Veterinary Microbiology, 2006Gammaherpesviruses are members of an emerging subfamily among the Herpesviridae. Two genera are discriminated: (i) lymphocryptovirus, including its type species Epstein-Barr virus (EBV), and (ii) rhadinovirus, including viruses of interest for medicine, veterinary medicine, and biomedical research, i.e.
Mathias Ackermann
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Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis
Seminars in Cancer Biology, 1999Herpesvirus saimiri (HVS) causes T-lymphoproliferative dis-$borders in several New World and Old World primate species and in certain rabbits.In vitro infection leads to permanent growth of primary T cells of primate and human origins. The transformation-relevant proteins of HVS interact with cellular proto-oncoproteins which results in cell growth ...
J U, Jung +3 more
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Murine Gammaherpesvirus 68: A Small Animal Model for Gammaherpesvirus-Associated Diseases
2017Murine gammaherpesvirus 68 (MHV68) is a naturally occurring pathogen of murid rodents that is genetically related to the human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV). Viral, immunologic, and disease parameters following experimental infection of laboratory mice with MHV68 closely resemble what ...
Sihan, Dong +2 more
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Virology, 2011 Association of herpesvirus DNA with histones has important implications for lytic and latent infections; thus herpesviruses arbitrate interactions with histones to productively infect host cells.
Bryan C Mounce, Vera L Tarakanova
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Interactions of the murine gammaherpesvirus with the immune system
Current Opinion in Immunology, 1994Our understanding of the host response to gammaherpesviruses comes largely from studies on Epstein-Barr virus. A recent addition to this family is murine herpesvirus-68 which, like Epstein-Barr virus, establishes a latent infection in B lymphocytes and is associated with lymphoproliferative disease.
A A, Nash, N P, Sunil-Chandra
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Detection of a novel bat gammaherpesvirus in Hungary
Acta Veterinaria Hungarica, 2008This paper describes the detection of a novel herpesvirus in a Serotine bat ( Eptesicus serotinus ) in Hungary. The rescued animal showed signs of icterus and anorexia and died within a day, in spite of immediate supportive therapy. Autopsy confirmed the clinical picture by the major lesions observed in the liver.
Molnár, Viktor +7 more
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Virology, 2011 Gammaherpesvirus protein kinases are an attractive therapeutic target as they support lytic replication and latency. Via an unknown mechanism these kinases enhance expression of select viral genes and DNA synthesis.
Bryan C Mounce +2 more
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Immune Mechanisms in Murine Gammaherpesvirus-68 Infection
Viral Immunology, 2005The murine gamma-herpesvirus-68 (MHV-68) is a relative of the Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) that infects mice. All these gamma-herpesviruses are subject to immune control, but limit the impact of this control through immune evasion. Molecular evasion mechanisms have been described in abundance.
Stevenson, Philip G., Efstathiou, Stacey
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Animal Models of Human Gammaherpesvirus Infections
2018Humans are the only natural host of both Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), and this strict host tropism has hampered the development of animal models of these human gammaherpesviruses. To overcome this difficulty and develop useful models for these viruses, three main approaches have been employed: first ...
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