Results 1 to 10 of about 218,731 (306)
miRNA Changes in Retinal Ganglion Cells after Optic Nerve Crush and Glaucomatous Damage
Cells, 2021 The purpose of this study was to characterize the miRNA profile of purified retinal ganglion cells (RGC) from healthy and diseased rat retina. Diseased retina includes those after a traumatic optic nerve crush (ONC), and after ocular hypertension ...
Ben Mead +3 more
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eLife, 2023 Melanopsin signaling within intrinsically photosensitive retinal ganglion cell (ipRGC) subtypes impacts a broad range of behaviors from circadian photoentrainment to conscious visual perception.
Ely Contreras +4 more
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Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]
PLoS Genetics, 2005 In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby +6 more
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Acta Neuropathologica Communications, 2023 Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range.
Alessio Canovai +7 more
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Journal of the Egyptian Ophthalmological Society, 2020 Purpose The aim was to assess radial peripapillary capillary (RPC) and macular vascular density in eyes with primary open angle glaucoma (POAG). Patients and methods This observational cross-sectional study included 60 eyes of normal person and 67 eyes ...
Haitham Y Al-Nashar +2 more
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Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma. [PDF]
PLoS ONE, 2013 Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and accompanying visual field loss.
Pete A Williams +6 more
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Protecting retinal ganglion cells [PDF]
Eye, 2017 Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including ...
T Z, Khatib, K R, Martin
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Expression of EFR3A in the mouse cochlea during degeneration of spiral ganglion following hair cell loss. [PDF]
PLoS ONE, 2015 Retrograde degeneration of spiral ganglion cells in the cochlea following hair cell loss is similar to dying back in pathology. The EFR3A gene has recently been discovered to be involved in the pathogenesis of dying back.
Chen Nie +5 more
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Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies
Biology, 2021 Retinal ganglion cells (RGCs) comprise a heterogenous group of projection neurons that transmit visual information from the retina to the brain. Progressive degeneration of these cells, as it occurs in inflammatory, ischemic, traumatic or glaucomatous ...
Yue Hu +3 more
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Retinal ganglion cells in diabetes [PDF]
The Journal of Physiology, 2008 Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting
Timothy S, Kern, Alistair J, Barber
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