Results 21 to 30 of about 218,731 (306)

Evaluation of neuroprotective agents acting via the BDNF–TrkB pathway using AI‐enabled predictions of ligand–receptor interactions

open access: yesMedComm – Future Medicine, 2022
Glaucoma is the leading cause of irreversible blindness globally and is associated with retinal ganglion cell (RGC) death. Brain‐derived neurotrophic factor (BDNF) is a potent neurotrophin that promotes neuronal survival via its receptor, tropomyosin ...
Jing Zhu   +13 more
doaj   +1 more source

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

open access: yesMolecular Brain, 2018
Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma.
James R. Tribble   +4 more
doaj   +1 more source

Changes in intrinsic excitability of ganglion cells in degenerated retinas of RCS rats [PDF]

open access: yesInternational Journal of Ophthalmology, 2018
AIM: To evaluate the intrinsic excitability of retinal ganglion cells (RGCs) in degenerated retinas. METHODS: The intrinsic excitability of various morphologically defined RGC types using a combination of patch-clamp recording and the Lucifer yellow ...
Yi-Ming Ren   +3 more
doaj   +1 more source

GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons

open access: yeseLife, 2021
Output signals of neural circuits, including the retina, are shaped by a combination of excitatory and inhibitory signals. Inhibitory signals can act presynaptically on axon terminals to control neurotransmitter release and regulate circuit function ...
Jenna Nagy   +3 more
doaj   +1 more source

Organization of the dorsal lateral geniculate nucleus in the mouse [PDF]

open access: yes, 2017
The dorsal lateral geniculate nucleus (dLGN) of the thalamus is the principal conduit for visual information from retina to visual cortex. Viewed initially as a simple relay, recent studies in the mouse reveal far greater complexity in the way input from
Guido, William, Kerschensteiner, Daniel
core   +2 more sources

Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina. [PDF]

open access: yes, 2014
This paper examines the role of inhibition in generating the receptive-field properties of local edge detector (LED) ganglion cells in the rabbit retina. We confirm that the feed-forward inhibition is largely glycinergic but, contrary to a recent report,
Buldyrev, Ilya   +5 more
core   +4 more sources

Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. [PDF]

open access: yes, 2018
The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events.
Hashimoto, Takao   +3 more
core   +1 more source

Transformation of stimulus correlations by the retina [PDF]

open access: yes, 2013
Redundancies and correlations in the responses of sensory neurons seem to waste neural resources but can carry cues about structured stimuli and may help the brain to correct for response errors.
Balasubramanian, V.   +7 more
core   +7 more sources

Phototransduction in ganglion-cell photoreceptors [PDF]

open access: yesPflügers Archiv - European Journal of Physiology, 2007
A third class of photoreceptors has recently been identified in the mammalian retina. They are a rare cell type within the class of ganglion cells, which are the output cells of the retina. These intrinsically photosensitive retinal ganglion cells support a variety of physiological responses to daylight, including synchronization of circadian rhythms ...
openaire   +2 more sources

Higher Network Activity Induced by Tactile Compared to Electrical Stimulation of Leech Mechanoreceptors [PDF]

open access: yes, 2018
The tiny ensemble of neurons in the leech ganglion can discriminate the locations of touch stimuli on the skin as precisely as a human fingertip. The leech uses this ability to locally bend the body-wall away from the stimulus. It is assumed that a three-
Fathiazar, Elham   +2 more
core   +3 more sources

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