Results 51 to 60 of about 218,731 (306)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma

Neural Regeneration Research
Glaucoma is characterized by chronic progressive optic nerve damage and retinal ganglion cell death. Although extensive research has been conducted on neuroprotection for retinal ganglion cells, there is still no treatment for clinical use.
Esmahan Durmaz, Maryam Esmaeili, Philip Lewis, Gloria Cimaglia, Aled Clayton, Ben Mead   +5 more
doaj   +1 more source

Strategic Positioning of Connexin36 Gap Junctions Across Human Retinal Ganglion Cell Dendritic Arbors

Frontiers in Cellular Neuroscience, 2018
Connexin36 (Cx36) subunits form gap junctions (GJ) between neurons throughout the central nervous system. Such GJs of the mammalian retina serve the transmission, averaging and correlation of signals prior to conveying visual information to the brain ...
Orsolya Kántor, Orsolya Kántor, Orsolya Kántor, Gergely Szarka, Gergely Szarka, Gergely Szarka, Gergely Szarka, Zsigmond Benkő, Zoltán Somogyvári, Emese Pálfi, Gábor Baksa, Gergely Rácz, Roland Nitschke, Roland Nitschke, Gábor Debertin, Gábor Debertin, Gábor Debertin, Gábor Debertin, Béla Völgyi, Béla Völgyi, Béla Völgyi, Béla Völgyi   +21 more
doaj   +1 more source

Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. [PDF]

PLoS ONE, 2013
Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown.
Jun Yu, Lu Wang, Shi-Jun Weng, Xiong-Li Yang, Dao-Qi Zhang, Yong-Mei Zhong   +5 more
doaj   +1 more source

A Nonlinear Model of Spatiotemporal Retinal Processing: Simulations of X and Y Retinal Ganglion Cell Behavior [PDF]

, 1993
This article describes a nonlinear model of neural processing in the vertebrate retina, comprising model photoreceptors, model push-pull bipolar cells, and model ganglion cells.
Gaudiano, Paolo
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Live Demonstration: Retinal ganglion cell software and FPGA implementation for object detection and tracking [PDF]

, 2016
This demonstration shows how object detection and tracking are possible thanks to a new implementation which takes inspiration from the visual processing of a particular type of ganglion cell in the ...
Delbrück, Tobias, Linares Barranco, Alejandro, Moeys, Diederick P., Ríos Navarro, José Antonio   +3 more
core  

Encoding of Tactile Stimuli by Mechanoreceptors and Interneurons of the Medicinal Leech [PDF]

, 2016
For many animals processing of tactile information is a crucial task in behavioral contexts like exploration, foraging, and stimulus avoidance. The leech, having infrequent access to food, developed an energy efficient reaction to tactile stimuli ...
Fathiazar, Elham, Hilgen, Gerrit, Kretzberg, Jutta, Pirschel, Friederice   +3 more
core   +4 more sources

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Ganglion cell analysis versus retinal nerve fiber layer thickness in glaucoma diagnosis

Journal of the Egyptian Ophthalmological Society, 2019
Background Glaucoma is a progressive optic neuropathy, which can result in irreversible blindness. The main pathologic change in glaucoma is retinal ganglion cell loss. The macula has the greatest density of retinal ganglion cells (∼50%).
Tarek Tawfik Soliman, Elham Abd Alazeem Gad, Sarah Mohamed Selim   +2 more
doaj   +1 more source