Results 61 to 70 of about 218,731 (306)

Peritoneal macrophages attenuate retinal ganglion cell survival and neurite outgrowth

Neural Regeneration Research, 2021
Inflammation is a critical pathophysiological process that modulates neuronal survival in the central nervous system after disease or injury. However, the effects and mechanisms of macrophage activation on neuronal survival remain unclear. In the present
Jia-Jian Liang, Yu-Fen Liu, Tsz Kin Ng, Ci-Yan Xu, Mingzhi Zhang, Chi Pui Pang, Ling-Ping Cen   +6 more
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Inhibition of BDNF-AS Provides Neuroprotection for Retinal Ganglion Cells against Ischemic Injury. [PDF]

PLoS ONE, 2016
Brain-derived neurotrophic factor (BDNF) protects retinal ganglion cells against ischemia in ocular degenerative diseases. We aimed to determine the effect of BDNF-AS on the ischemic injury of retinal ganglion cells.The levels of BDNF and BDNF-AS were ...
Lifang Xu, Ziyin Zhang, Tianhua Xie, Xiaoyang Zhang, Tu Dai   +4 more
doaj   +1 more source

Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury

Neural Regeneration Research, 2023
[INLINE:1] Vision depends on accurate signal conduction from the retina to the brain through the optic nerve, an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.
Zhe Liu, Jingfei Xue, Canying Liu, Jiahui Tang, Siting Wu, Jicheng Lin, Jiaxu Han, Qi Zhang, Caiqing Wu, Haishun Huang, Ling Zhao, Yehong Zhuo, Yiqing Li   +12 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Spatial Expression Pattern of the Major Ca²⁺-Buffer Proteins in Mouse Retinal Ganglion Cells

Cells, 2020
The most prevalent Ca2+-buffer proteins (CaBPs: parvalbumin—PV; calbindin—CaB; calretinin—CaR) are widely expressed by various neurons throughout the brain, including the retinal ganglion cells (RGCs).
Tamás Kovács-Öller, Gergely Szarka, Ádám J. Tengölics, Alma Ganczer, Boglárka Balogh, Edina Szabó-Meleg, Miklós Nyitrai, Béla Völgyi   +7 more
doaj   +1 more source

Lepidium sativum as candidate against excitotoxicity in retinal ganglion cells

Translational Neuroscience, 2021
Glutamate excitotoxicity is considered one of the major causes of retinal ganglion cell death in many retinal diseases. Retinal ganglion cell degeneration causes severe blindness since visual signals from the eye to the brain are conducted only through ...
Al-Dbass Abeer, Amina Musarat, Al Musayeib Nawal M., El-Anssary Amira A., Bhat Ramesa Shafi, Fahmy Rania, Alhamdan Majd M., El-Ansary Afaf   +7 more
doaj   +1 more source

Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development

Frontiers in Molecular Biosciences, 2022
Although mutations in ADAMTS10 have long been known to cause autosomal recessive Weill-Marchesani Syndrome which is characterized by short stature and ocular abnormalities, more recent work has shown that certain mutations in ADAMTS10 cause glaucoma in ...
Lauren K. Wareham, Amy E. Whitener, Hang-Jing Wu, Shu-Yu Wu, Hassane S. Mchaourab, Douglas P. Mortlock, Rachel W. Kuchtey, Rachel W. Kuchtey, John Kuchtey   +8 more
doaj   +1 more source

On the Potential of the Excluded Volume and Auto-Correlation as Neuromorphometric Descriptors

, 2005
This work investigates at what degree two neuromorphometric measurements, namely the autocorrelation and the excluded volume of a neuronal cell can influence the characterization and classification of such a type of cells.
Barbosa, Boycott, Cajal, Coelho, Cook, Costa, Costa, Costa, Costa, Fernandez, Isihara, Jones, L. da F. Costa, M.S. Barbosa, McLachlan, Morigiwa, Morita, Onsager, Rodieck, Smith, V. Coupez, Wässle   +21 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source