Results 261 to 270 of about 79,768 (305)

Gangliosides of Melanoma

The Journal of Dermatology, 1992
AbstractThe relationships between the ganglioside composition of melanomas and their biologic behavior were investigated. (1) The amount of GM2 and/or GD2 in melanoma cells injected into nude mice correlated with the tumor growth rate. (2) GD2 content of melanoma cell lines correlated with sensitivity to radiation and vincristine. (3) GM2 expression of
T, Tsuchida, Y, Ishibashi
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Gangliosides in Neuroblastomas

Neurochemical Pathology, 1988
Neuroblastomas from children presenting with tumors at various ages and different primary sites (abdominal, adrenals, pelvic, and thoracic) were studied. Analysis of the ganglioside patterns of 53 tumors indicated that patients who were either disease positive 2 yr following surgery or dead of disease, had significantly (p less than 0.005) less GT1b ...
C L, Schengrund, S J, Shochat
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Ganglioside headgroup dynamics

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1980
Gangliosides, spin-labelled specifically on N-acetylneuraminic acid residues or on random-headgroup sugars, have been used to extend previous studies of headgroup behaviour. Headgroup sugar mobility is seen to be homogeneous and relatively unrestricted in a range of systems including three lines of cultured cells. The effects of temperature and pH have
P M, Lee, N V, Ketis, K R, Barber, C W, Grant   +3 more
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Human placenta gangliosides

Lipids, 1988
AbstractGangliosides extracted from human placenta were composed of four major components (G1–G4), which were purified by silica beads column chromatography. The structures of these gangliosides were analyzed by exoglycosidase treatments, 400 MHz proton magnetic resonance spectroscopy and gas chromatography‐mass spectrometry and were concluded to be as
T, Taki, K, Matsuo, K, Yamamoto, T, Matsubara, A, Hayashi, T, Abe, M, Matsumoto   +6 more
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Mouse liver gangliosides

Carbohydrate Research, 1986
The major gangliosides from mouse liver were purified and characterized by t.l.c., g.l.c., sialidase treatment, and a methylation study. GM3(NeuAc), GM3(NeuGc), GM2(NeuGc), GM1(NeuGc), and GDla(NeuGc, NeuGc) were identified. The structural identification of three of the gangliosides, GM2(NeuGc), GM1(NeuGc), and GDla(NeuGc, NeuGc), was supported by the ...
M, Suzuki, K, Nakamura, Y, Hashimoto, A, Suzuki, T, Yamakawa   +4 more
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Gangliosides and parkinsonism

Neurology, 1993
The protective effect of GM1 ganglioside against nerve cell death induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was analyzed in monkey mesencephalon. Administration of GM1 before and during MPTP treatment improved motor performances compared with MPTP-treated animals that received saline rather than GM1.
M T, Herrero, A, Kastner, I, Perez-Otaño, E C, Hirsch, M R, Luquin, F, Javoy-Agid, J, Del Río, J A, Obeso, Y, Agid   +8 more
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Gangliosides and Tumors

2018
Tumor-associated gangliosides play important roles in regulation of signal transduction induced by growth-factor receptors including EGFR, FGFR, HGF and PDGFR in a specific microdomain called glycosynapse in the cancer cell membranes, and in interaction with glycan recognition molecules involved in cell adhesion and immune regulation including ...
Reiji, Kannagi, Bi-He, Cai, Hsiang-Chi, Huang, Chia-Chun, Chao, Keiichiro, Sakuma   +4 more
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Neonatal dietary gangliosides

Early Human Development, 1998
Gangliosides are glycosphingolipids that are widely distributed in vertebrate tissues and body fluids and which are specially abundant in neural tissues. Milk from different species has a particular ganglioside content and profile. Human milk has a higher content of gangliosides than bovine milk.
R, Rueda, J, Maldonado, E, Narbona, A, Gil   +3 more
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Gangliosides and atherosclerosis

Lipids, 1994
AbstractThe ganglioside levels in atherosclerotic lesions of human aorta are considerably higher than those in unaffected areas of aorta, and atherosclerotic patients frequently have increased concentrations of serum gangliosides. The present review summarizes recent findings that suggest the possible involvement of aortic gangliosides in platelet ...
N V, Prokazova, L D, Bergelson
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Gangliosides as Immunomodulators

2007
Gangliosides are glycosphingolipids expressed at the outer leaflet of the plasmatic membrane of cells from vertebrate organisms. These molecules exert diverse biological functions including modulation of the immune system responses. Aberrant expression of gangliosides has been demonstrated on malignant cells. Besides expression on tumor cell membranes,
Miroslava, Potapenko, Galina V, Shurin, Joel, de León   +2 more
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