Results 1 to 10 of about 28,808 (171)

GD2 is a Crucial Ganglioside in the Signal Modulation and Application as a Target of Cancer Therapeutics. [PDF]

Cancer Sci
Among cancer‐associated antigens, ganglioside GD2 is the most crucial and essential carbohydrate antigen as a modulator of malignant signals and as a target of immunotherapy for refractory cancers. In particular, GD2 is now believed to be a marker of cancer stem cells and to be essentially involved in the features of cancer stemness.
Furukawa K, Ohmi Y, Hamamura K, Ohkawa Y, Hashimoto N, Tajima O, Kaneko K, Furukawa K.   +7 more
europepmc   +2 more sources

Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single‐center, open‐label, prospective study

Ibrain, EarlyView., 2023
Compound porcine perebroside and ganglioside injection (CPCGI) was used to treat ischemic stroke. However, there was no clinical evidence of low‐dose CPCGI. We conducted a clinical study to analyze whether the clinical results of low‐dose and standard‐dose CPCGI in patients with ischemic stroke were different.
Ya Chen, Xia Zhang, Hai‐Qing Zhang, Zhong Luo, Xue‐Jiao Zhou, Tao Liang, Fei Yang, Jun Zhang, Zu‐Cai Xu   +8 more
wiley   +1 more source

Gangliosides and Neuroblastomas [PDF]

International Journal of Molecular Sciences, 2020
The focus of this review is the ganglio-series of glycosphingolipids found in neuroblastoma (NB) and the myriad of unanswered questions associated with their possible role(s) in this cancer. NB is one of the more common solid malignancies of children. Five-year survival for those diagnosed with low risk NB is 90–95%, while that for children with high ...
openaire   +2 more sources

Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil. [PDF]

, 2019
Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes.
Alcantara, Luiz Carlos Junior, de Siqueira, Isadora Cristina, do Rosário, Mateus Santana, Ernst, Joel D, Mota, Sabrina, Pereira de Jesus, Pedro Antônio, Rivera-Correa, Juan, Rodriguez, Ana   +7 more
core   +1 more source

Glycomic analysis of high density lipoprotein shows a highly sialylated particle. [PDF]

, 2014
Many of the functional proteins and lipids in high density lipoprotein (HDL) particles are potentially glycosylated, yet very little is known about the glycoconjugates of HDL.
German, J Bruce, Huang, Jincui, Lebrilla, Carlito B, Lee, Hyeyoung, Rivera, Nancy, Smilowitz, Jennifer T, Zivkovic, Angela M   +6 more
core   +1 more source

Neuromuscular synaptic transmission in aged ganglioside-deficient mice [PDF]

, 2011
Gangliosides are sialylated glycosphingolipids that are present in high density on neuronal membranes, especially at synapses, where they are assumed to play functional or modulating roles.
Furukawa, K., Furukawa, K., Jacobs, B.C., Plomp, J.J., Todorov, B., Verschuuren, J.J., Willison, H.J., Zitman, F.M.P.   +7 more
core   +1 more source

The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice [PDF]

, 2013
Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.
Cunningham, Madeleine E., Furukawa, Koichi, Rupp, Angie, Willison, Hugh J., Yao, Denggao   +4 more
core   +1 more source

Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Ando, Ang, B. Todorov, B.C. Jacobs, Buchwald, Bullens, Chamberlain, Chen, Chiavegatto, Desplats, Egorushkina, F.M.P. Zitman, Fishman, Furuse, Gong, Green, H.J. Willison, Hakomori, Halstead, Halstead, Hashiramoto, Inoue, Isaev, J.J. Plomp, J.J. Verschuuren, K. Furukawa, K. Furukawa, Kaja, Kappel, Kawai, Lang, Ledeen, Ledeen, Liu, Magleby, Marconi, McLachlan, Meir, Nakatani, Ngamukote, O'Hanlon, Okada, Ortiz, Plomp, Proia, Rahmann, Ramirez, Roth, Salaun, Santafe, Sheikh, Simpson, Sohn, Sonnino, Stevens, Sugiura, Susuki, Svennerholm, Takamiya, Tanaka, Taverna, Tettamanti, Varoqueaux, Wang, Wieraszko, Willison, Wood, Wu, Wu, Wu, Wu, Yamashita, Yates   +72 more
core   +1 more source

Immune Response Modulation by Tumor-Secreted Glycosphingolipids [PDF]

, 2014
Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis.
Cely, Ingrid, Lardone, Ricardo Dante, Lee, Delphine, Sieling, Peter A.   +3 more
core   +1 more source

Gangliosides of Human Melanoma2 [PDF]

JNCI: Journal of the National Cancer Institute, 1987
Human melanoma synthesizes a large quantity of gangliosides, glycosphingolipids containing sialic acid. The authors previously have demonstrated that the ganglioside profile differs among individual melanomas and is widely heterogeneous. In the current study, a retrospective study was performed to compare the relationship between the quantity of five ...
Romaine E. Saxton, Tetsuya Tsuchida, Donald L. Morton, Reiko F. Irie   +3 more
openaire   +5 more sources