Results 11 to 20 of about 51,895 (265)
Anti-inflammatory role of GM1 and other gangliosides on microglia
Journal of Neuroinflammation, 2022 Background Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation.
Danny Galleguillos +15 more
doaj +2 more sources
Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications
Frontiers in Neuroscience, 2020 Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane microdomains (“lipid rafts”) and play important roles in the modulation of ...
Simonetta Sipione +4 more
doaj +2 more sources
O-acetylated Gangliosides as Targets for Cancer Immunotherapy
Cells, 2020 O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.
Sumeyye Cavdarli +2 more
doaj +2 more sources
Journal of Lipid Research, 1964 The results of recent studies on the complexities of gangliosides from brain, spleen, and erythrocyte stroma are described, and ganglioside nomenclature is discussed.
Lars Svennerholm
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Molecular recognition of gangliosides and their potential for cancer immunotherapies
Frontiers in Immunology, 2014 Gangliosides are sialic acid-containing glycosphingolipids expressed on all vertebrate cells. They are primarily positioned in the plasma membrane, with the ceramide part anchored in the membrane and the glycan part exposed on the surface of the cell ...
Ute eKrengel, Paula A Bousquet
doaj +2 more sources
How Do Gangliosides Regulate RTKs Signaling?
Cells, 2013 Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including ...
Sylvain Julien +4 more
doaj +2 more sources
Gangliosides as Signaling Regulators in Cancer
International Journal of Molecular Sciences, 2021 At the plasma membrane, gangliosides, a group of glycosphingolipids, are expressed along with glycosphingolipids, phospholipids, and cholesterol in so-called lipid rafts that interact with signaling receptors and related molecules.
Norihiko Sasaki, M. Toyoda, T. Ishiwata
semanticscholar +1 more source
Physiology of gangliosides and the role of antiganglioside antibodies in human diseases
Cellular & Molecular Immunology, 2020 Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human body.
G. Cutillo +2 more
semanticscholar +1 more source
Production of multiple brain-like ganglioside species is dispensable for fas-induced apoptosis of lymphoid cells. [PDF]
PLoS ONE, 2011 Activation of an acid sphingomyelinase (aSMase) leading to a biosynthesis of GD3 disialoganglioside has been associated with Fas-induced apoptosis of lymphoid cells. The present study was undertaken to clarify the role of this enzyme in the generation of
Iuliana Popa +5 more
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Glycomic analysis of high density lipoprotein shows a highly sialylated particle. [PDF]
, 2014 Many of the functional proteins and lipids in high density lipoprotein (HDL) particles are potentially glycosylated, yet very little is known about the glycoconjugates of HDL.
German, J Bruce +6 more
core +1 more source