The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice [PDF]
, 2013 Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.
Cunningham, Madeleine E. +4 more
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TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines. [PDF]
PLoS ONE, 2018 Gangliosides are glycosphingolipids concentrated in glycolipid-enriched membrane microdomains. Mainly restricted to the nervous system in healthy adult, complex gangliosides such as GD3 and GD2 have been shown to be involved in aggressiveness and ...
Justine H Dewald +8 more
doaj +1 more source
Immune Response Modulation by Tumor-Secreted Glycosphingolipids [PDF]
, 2014 Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis.
Cely, Ingrid +3 more
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Ganglioside Biochemistry [PDF]
ISRN Biochemistry, 2012 Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence, and metabolism. Key functional, biochemical, and pathobiochemical aspects are
openaire +2 more sources
Diet-Induced Changes in Spectrum Patterns of Serum Gangliosides in 6-Month-Old Infants
Majalah Kedokteran Bandung, 2012 Human milk contains higher levels of gangliosides than infant formula. Gangliosides play a role in neuronal growth, migration and maturation, sinaptogenesis, and myelination.
Dida A. Gurnida +7 more
doaj +1 more source
Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance [PDF]
, 2016 Sialyltransferases are a family of 20 gene products in mice and humans that transfer sialic acid from its activated precursor, CMP-sialic acid, to the terminus of glycoprotein and glycolipid acceptors.
Aja, Susan +7 more
core +1 more source
Gangliosides: Treatment Avenues in Neurodegenerative Disease
Frontiers in Neurology, 2019 Gangliosides are cell membrane components, most abundantly in the central nervous system (CNS) where they exert among others neuro-protective and -restorative functions.
P. Magistretti +9 more
semanticscholar +1 more source
Recovery of gangliosides from aqueous solutions on styrene-divinylbenzene copolymer columns1
Journal of Lipid Research, 2002 An investigation was made using a styrene-divinylbenzene copolymer as a solid phase sorbent to recover gangliosides from aqueous solutions. A comparison with octadecyl-bonded (C18) silica gel showed that the general procedure used to purify gangliosides ...
Iuliana Popa +3 more
doaj +1 more source
Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]
PLoS ONE, 2012 Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez +6 more
doaj +1 more source
Frontiers in Nutrition, 2021 Background and Aims: Dietary gangliosides are present in human milk and consumed in low amounts from organ meats. Clinical and animal studies indicate that dietary gangliosides attenuate signaling processes that are a hallmark of inflammatory bowel ...
John J. Miklavcic +7 more
doaj +1 more source