Results 21 to 30 of about 28,808 (171)
The biosynthesis of brain gangliosides. Separation of membranes with different ratios of ganglioside sialylating activity to gangliosides [PDF]
Biochemical Journal, 1977 Brain subcellular fractions were analysed for ganglioside-sialylating activity by measuring the incorporation of N-[3H]acetylneuraminic acid from CMP-N-[3H]acetylneuraminic acid into endogenous ganglioside acceptors (endogenous incorporation) and into exogenous lactosyceramide (haematoside synthetase activity). The ratios of endogenous incorporation to
Ranwel Caputto +3 more
openaire +3 more sources
Role of Prion protein-EGFR multimolecular complex during neuronal differentiation of human dental pulp-derived stem cells [PDF]
, 2018 Cellular prion protein (PrPC) is expressed in a wide variety of stem cells in which regulates their self-renewal as well as differentiation potential. In this study we investigated the presence of PrPCin human dental pulp-derived stem cells (hDPSCs) and ...
Manganelli, Valeria +6 more
core +1 more source
Glycosylphosphatidylinositols: More than just an anchor? [PDF]
, 2016 There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached ...
Bate, C, Nolan, W, Williams, A
core +1 more source
Vascular Diseases and Gangliosides [PDF]
International Journal of Molecular Sciences, 2019 Vascular diseases, such as myocardial infarction and cerebral infarction, are most commonly caused by atherosclerosis, one of the leading causes of death worldwide. Risk factors for atherosclerosis include lifestyle and aging. It has been reported that lifespan could be extended in mice by targeting senescent cells, which led to the suppression of ...
Norihiko Sasaki, Masashi Toyoda
openaire +2 more sources
Advanced Science, EarlyView.The molecular recognition of the sugar moiety of GD3 and Gb3 (globotriaosylceramide) derivatives by Siglec‐7 has been thoroughly studied offering insights for cancer diagnostics and therapies. A combination of structural biology techniques, nuclear magnetic resonance (NMR) spectroscopy, physicochemical analysis, and in silico methods suggested that ...
Cristina Di Carluccio +15 more
wiley +1 more source
Differential binding patterns of anti-sulfatide antibodies to glial membranes [PDF]
, 2018 Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may ...
Barrie, Jennifer A. +8 more
core +1 more source
Advanced Science, EarlyView.A reversible wet chemical surface functionalization results in dynamic multivalent receptors showing ligand‐specific high affinity for lectins and bacteria. Abstract The paper reports the design of multivalent bacterial receptors based on reversible self‐assembled monolayers (rSAMs) on gold and glass substrates, mimicking the ligand display on host ...
Thomas Hix‐Janssens +12 more
wiley +1 more source
Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]
, 2019 The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B +3 more
core +2 more sources
Animal Models and Experimental Medicine, EarlyView.Sydenham's chorea (SC) is the neurological manifestation associated with acute rheumatic fever (ARF), triggered by a group A streptococcal (GAS) infection. Anti‐GAS antibodies cross‐reacting with tissue proteins are implicated in the development of neurological changes. In this study, using an animal model, we demonstrate that a compromised blood–brain
Rukshan Ahamed Mohamed Rafeek +8 more
wiley +1 more source
Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. [PDF]
, 2013 VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that contains a large extracellular N terminus with 35 calcium-binding domains.
Fu, Ying-Hui +3 more
core +1 more source