Results 31 to 40 of about 28,808 (171)

“Ears of the Lynx” Sign on Brain MRI in Siblings With Spastic Paraplegia: A Case Report

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Hereditary spastic paraplegia (HSP) is a rare, clinically and genetically heterogenous condition that selectively affects the terminal segment of the descending corticospinal tract of the lumbar spine area, causing lower extremity spastic weakness with or without associated complex neurological symptoms.
Qingqing Wang, Manikum Moodley
wiley   +1 more source

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

Gangliosides in milk

Mljekarstvo, 2016
Gangliosides belong to a group of glycosphingolipids which are naturally found in biological tissues and fluids including mammalian milks. Considering milk, gangliosides are exclusively found in the membrane of the milk fat globule. Recently, gangliosides are becoming more and more interesting due to their numerous functions.
Marko Mesarić, Slavica Potočki
openaire   +3 more sources

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source

Targeting SHMT2‐mediated membrane phospholipid remodeling for enhanced anti‐GCSCs treatment

Interdisciplinary Medicine, EarlyView.
Depletion of serine via serine hydroxymethyltransferase‐2 (SHMT2) knockdown in gastric cancer (GC) disrupted the maintenance of gastric cancer stem cell stemness by inducing membrane phospholipid remodeling and aberrant CD44 shedding within membrane lipid rafts. The synthesized HA‐Exo‐si SHMT2 demonstrated enhanced therapeutic efficacy and safety in GC.
Liping Yang, Fangli Liao, Yanran Tong, Tong Huang, Yan‐e Du, Siyang Wen, Linshan Jiang, Lanlang Peng, Hua Sun, Gaoli Zhang, Weixian Chen   +10 more
wiley   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Investigating the interaction between the tetraspanin CD82 and gangliosides, and, The binding partners of CLEC14A and the function of the CLEC14A extracellular domain [PDF]

, 2012
Project 1: CD82 is a tetraspanin involved in tumour metastasis suppression. It is downregulated in several cancers including breast, liver and prostate cancer.
Lodhia, Puja
core  

Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents [PDF]

, 2016
Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of ...
Ahmed, Albertini, Alfonso, Alfonso, Andreesen, Baeuerle, Battula, Bennaceur, Bennaceur, Biswas, Boligan, Brändlein, Cacciavillano, Caldwell, Cheever, Cheresh, Chu, Crespo, Crespo, Daniotti, Daniotti, Daniotti, d’Azzo, Esser, Gajdosik, Gilbert, Gilewski, Guerrera, Guillemard, Guillemard, Gómez, Hakomori, Hakomori, Hanada, Harlalka, Heitger, Hernández, Higgins, Hoon, Horwacik, Hu, Huang, Hudak, Hume, Iglesias-Bartolomé, Inokuchi, Irani, Iwamori, Jandus, Kanda, Kanda, Kanda, Kanda, Kawasaki, Kieber-Emmons, Kim, Kim, Kimata, Kimata, Kloppel, Kolter, Kolter, Kolter, Kudo, Kwon, Lacombe, Lahera, Lardone, Lauc, Lee, Lee, Lefebvre, Liu, Lo, Lode, Lopez, Louis, Maccioni, Maccioni, Maccioni, Mahata, Matthay, McKallip, Mencarelli, Merrill, Miyagi, Morton, Nakamori, Nasi, Navid, Nguyen, Nicoll, Nores, Olshefski, Parsons, Pearce, Pellegrini, Platt, Porcelli, Portoukalian, Prinetti, Proia, Pukel, Pule, Péguet-Navarro, Qiu, Raval, Ravindranath, Rayman, Regina Todeschini, Rodriguez-Walker, Rodriguez-Zhurbenko, Rodríguez-Zhurbenko, Sa, Sandhoff, Sarkar, Schneider, Sharma, Shen, Shen, Shusterman, Simpson, Slovin, Sonnino, Sriram, Tangvoranuntakul, Tettamanti, Thornton, Tokuda, Torbidoni, Torres Demichelis, Uzzo, van Cruijsen, Vilcaes, Vázquez, Vázquez, Vázquez, Wang, Webb, Weiner, Wondimu, Wölfl, Yamashita, Yogeeswaran, Young, Yu, Zamai, Zhang, Zhou, Zhu, Ziegler-Heitbrock, Ziulkoski, Zurita   +152 more
core   +2 more sources

The Role of Gangliosides in Neurodevelopment [PDF]

Nutrients, 2015
Gangliosides are important components of neuronal cell membranes and it is widely accepted that they play a critical role in neuronal and brain development. They are functionally involved in neurotransmission and are thought to support the formation and stabilization of functional synapses and neural circuits required as the structural basis of memory ...
Kate Palmano, Paul McJarrow, Jian Guan, Angela Rowan, Rozey Guillermo   +4 more
openaire   +3 more sources

Recent advances in high‐resolution traveling wave‐based ion mobility separations coupled to mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Recently, ion mobility spectrometry‐mass spectrometry (IMS‐MS) has become more readily incorporated into various omics‐based workflows. These growing applications are due to developments in instrumentation within the last decade that have enabled higher‐resolution ion mobility separations.
Cameron N. Naylor, Gabe Nagy
wiley   +1 more source