Results 41 to 50 of about 28,808 (171)

Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination [PDF]

, 2017
Effective bidirectional signalling between axons and Schwann cells is essential for both the development and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can
Bennett, David L.H., Clark, Alex J., Galino, Jorge, Kaller, Malte S., Rinaldi, Simon, Willison, Hugh J.   +5 more
core   +2 more sources

Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, particularly their response to radiotherapy, is crucial for improving treatment outcomes and patient ...
Ahana Maitra, Morena Miciaccia, Manuela Mandorino, Domenico Armenise, Olga Maria Baldelli, Savina Ferorelli, Ludmila Papusha, Alexander Druy, Maria Grazia Perrone, Antonio Scilimati   +9 more
wiley   +1 more source

A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry [PDF]

, 2017
A novel bunyavirus was recently found to cause severe febrile illness with high mortality in agricultural regions of China, Japan, and South Korea. This virus, named severe fever with thrombocytopenia syndrome virus (SFTSV), represents a new group within
Bart, Stephen M., Bates, Paul, Brennan, Benjamin, Briley, Kenneth, Bushman, Frederic D., Drake, Mary Jane, Minutillo, Madeleine, Sherman, Eric, Szemiel, Agnieszka M.   +8 more
core   +3 more sources

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

Intercellular transfer of shed tumor cell gangliosides [PDF]

, 1996
Three distinct steps underlie immunosuppression by tumor gangliosides: (i) their shedding by the tumor cell, (ii) binding to target leukocytes in the tumor microenvironment, and (iii) action upon the target cell.
Ladisch, Stephan, Olshefski, Randal
core   +1 more source

Upregulation of ST3GAL5 predicts suppression of malignant biological behavior in bladder cancer

UroPrecision, EarlyView.
Abstract Background Bladder cancer (BLCA) is the most prevalent malignancy in the urinary tract system, while ST3GAL5 is a protein‐coding gene that catalyzes the formation of ganglioside monosialodihexosylganglioside 3 (GM3) synthase. GM3 synthase has been reported to significantly influence the malignant process of various cancers.
Song Ou‐Yang, Lei Tang, Lin Li, Yawei Zhao   +3 more
wiley   +1 more source

Sialic acid utilization by Cronobacter sakazakii [PDF]

, 2013
Background: The Cronobacter genus is composed of seven species, and can cause infections in all age groups. Of particular concern is C. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis and ...
Forsythe, S, Hariri, S, Joseph, S, Masood, N   +3 more
core   +1 more source

Effects of Aging on Glucose and Lipid Metabolism in Mice

Aging Cell, Volume 24, Issue 4, April 2025.
Lien et al. report a characterization of metabolism with aging across three different strains of mice. They find that glucose metabolism is robust during healthy aging; however, aging tissues exhibit evidence of upregulated fatty acid and sphingolipid metabolism reactions that regenerate NAD+ from NADH.
Evan C. Lien, Ngoc Vu, Anna M. Westermark, Laura V. Danai, Allison N. Lau, Yetiş Gültekin, Matthew A. Kukurugya, Bryson D. Bennett, Matthew G. Vander Heiden   +8 more
wiley   +1 more source

Low‐Intensity Pulsed Ultrasound Treatment Selectively Stimulates Senescent Cells to Promote SASP Factors for Immune Cell Recruitment

Aging Cell, Volume 24, Issue 5, May 2025.
The regulatory effects of low‐intensity pulsed ultrasound (LIPUS) stimulation in senescent cells are presented. LIPUS perturbs the membrane in senescent cells and induces intracellular reactive oxygen species via NOX4 expression. Consequently, secretion of senescence‐associated secretory phenotype, followed by migration of monocytes/macrophages and ...
HyeRan Gwak, Seoyoung Hong, Su Hyun Lee, In Woo Kim, Yonghan Kim, Hyungmin Kim, Ki Joo Pahk, So Yeon Kim   +7 more
wiley   +1 more source

Gangliosides for acute spinal cord injury. [PDF]

, 2005
BACKGROUND: Spinal cord injury (SCI) results in loss of feeling and movement. The consequences can be devastating for the patient and his or her carers. Global estimates of the number of new cases annually range from 15 to 40 per million.
Chinnock, P, Roberts, I
core   +1 more source