Results 61 to 70 of about 28,808 (171)
Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy
The FEBS Journal, EarlyView.Neurodegeneration is thought to arise due to the disruption of the protein homeostasis. In synucleinopathies, alterations in the levels of functional and aggregated aSyn lead to proteinopenia and proteinopathy, respectively. aSyn and β‐glucocerebrosidase are closely linked to lipid metabolism, impacting organelle function and lipidostasis.
Manuel Flores‐León, Tiago F. Outeiro
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Cell Propagation of Cholera Toxin CTA ADP-Ribosylating Factor by Exosome Mediated Transfer [PDF]
, 2018 In this study, we report how the cholera toxin (CT) A subunit (CTA), the enzyme moiety responsible for signaling alteration in host cells, enters the exosomal pathway, secretes extracellularly, transmits itself to a cell population.
Boussadia, Zaira +11 more
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Ganglioside antibodies and neuropathies
Current Opinion in Neurology, 2008 Continuing progress in the field of antiganglioside antibodies is expanding our comprehension of the pathogenesis of the inflammatory neuropathies. Recent studies have helped unravel all aspects of this process, addressing a range of subjects from the bacterial and host factors involved in antibody induction through to their pathogenic effects.This ...
Rinaldi, S, Willison, H
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International Journal of Cosmetic Science, EarlyView.The facial SC lipid profiles of young Chinese women in the early aging stage exhibited significant changes with age. The average chain length of diacylglycerol, triacylglycerol and short‐chain ceramides decreases with age, while the cholesteryl ester and ceramide EO subclasses increase. Some ceramides correlate positively with TEWL, skin elasticity and
Yumei Fan +6 more
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Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins. [PDF]
, 2018 Clostridium perfringens uses its large arsenal of protein toxins to produce histotoxic, neurologic and intestinal infections in humans and animals. The major toxins involved in diseases are alpha (CPA), beta (CPB), epsilon (ETX), iota (ITX), enterotoxin (
McClane, Bruce A +2 more
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Gangliosides in Membrane Organization
, 2018 Since the structure of GM1 was elucidated 55years ago, researchers have been attracted by the sialylated glycans of gangliosides. Gangliosides head groups, protruding toward the extracellular space, significantly contribute to the cell glycocalyx; and in certain cells, such as neurons, are major determinants of the features of the cell surface ...
Sonnino, Sandro +5 more
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Retrograde tracing of breast cancer‐associated sensory neurons
Journal of Microscopy, Volume 298, Issue 2, Page 232-244, May 2025.Abstract Breast cancer is one of the leading causes of mortality among women. The tumour microenvironment, consisting of host cells and extracellular matrix, has been increasingly studied for its interplay with cancer cells, and the resulting effect on tumour progression.
Svetllana Kallogjerovic +3 more
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Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts [PDF]
, 2009 Human islet amyloid polypeptide (hIAPP) is the primary component of the amyloid deposits found in the pancreatic islets of patients with type 2 diabetes mellitus. However, it is unknown how amyloid fibrils are formed in vivo.
Matsuzaki, Katsumi, Wakabayashi, Masaki
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Periodontology 2000, EarlyView.AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer +4 more
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Analytical Science Advances, Volume 6, Issue 1, June 2025.Abstract Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI‐MSI) is an emerging imaging tool that allows visualisation of hundreds of analytes unbiasedly in a single experiment. This paper highlights the adaptations of MALDI‐MSI in different context in 2024, such as clinical diagnostic, pharmacology, forensics applications ...
Yuen Tung Ngai +3 more
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