Results 81 to 90 of about 20,173 (228)

Intercellular transfer of shed tumor cell gangliosides

, 1996
Three distinct steps underlie immunosuppression by tumor gangliosides: (i) their shedding by the tumor cell, (ii) binding to target leukocytes in the tumor microenvironment, and (iii) action upon the target cell.
Olshefski, Randal, Ladisch, Stephan, Randal Olshefski, Stephan Ladisch   +3 more
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Gangliosides as modulators of cell function

, 1992
Gangliosides, sialic acid-containing glycosphingolipids, are found in the outer leaflet of the plasma membrane of all vertebrate tissues and species. This report presents a brief introduction to the gangliosides and reviews thechemistry and topography of
R. B. Marchase, C. B. Zeller
core   +1 more source

Partial synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification

Journal of Lipid Research, 2014
Within recent years, ganglioside patterns have been increasingly analyzed by MS. However, internal standards for calibration are only available for gangliosides GM1, GM2, and GM3.
Martin Gantner, Günter Schwarzmann, Konrad Sandhoff, Thomas Kolter   +3 more
doaj   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, Volume 13, Issue 33, 15 June 2026.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Gangliosides in subacute sclerosing leukoencephalitis: isolation and fatty acid composition of nine fractions

Journal of Lipid Research, 1968
Gangliosides from brain of an 8 yr old boy with subacute sclerosing leukoencephalitis have been studied in terms of pattern and structure. Thin-layer chromatography showed that both gray and white matter have a highly abnormal pattern, with elevation of ...
Robert Ledeen, Kenneth Salsman, Maria Cabrera   +2 more
doaj   +1 more source

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

: Gangliosides impair Langerhans cell function

, 2006
Gangliosides are ubiquitous, membrane-associated, glycosphingolipids, the composition and production of which is altered in many tumour cells. They have been shown to inhibit the in vitro generation and differentiation of dendritic cells (DCs) from ...
Jacques Portoukalian, Portoukalian, Jacques, Popa, Iuliana, Karim Bennaceur, Bennaceur, Karim, Josette Péguet-Navarro, Odile Berthier-Vergnes, Péguet-Navarro, Josette, Iuliana Popa, Berthier-Vergnes, Odile   +9 more
core   +1 more source

Gangliosides in the 21st century: therapeutic prospects for the brain and spine

Frontiers in Neurology
Gangliosides are sialylated glycosphingolipids highly enriched in the central nervous system, where they regulate membrane signaling, metabolism, neurogenesis, and immune responses.
Pierre J. Magistretti, Pierre J. Magistretti, Charles Finsterwald, Yutaka Itokazu, Yutaka Itokazu, Simonetta Sipione, Fred H. Geisler, Tarcisio Barros Filho   +7 more
doaj   +1 more source

Anabolic sialosylation of gangliosides in situ in rat brain cortical slices.

Journal of Lipid Research, 1989
Radiolabeling of the sialic acid residues of gangliosides was examined in thin slices of rat brain cerebral cortex incubated under physiologic conditions in the presence of either [14C]N-acetyl-mannosamine (ManNAc) or cytidine 5'-monophosphoryl-[14C]N ...
R Durrie, A Rosenberg
doaj   +1 more source