Results 101 to 110 of about 20,173 (228)
Vascular Diseases and Gangliosides
, 2019 Vascular diseases, such as myocardial infarction and cerebral infarction, are most commonly caused by atherosclerosis, one of the leading causes of death worldwide. Risk factors for atherosclerosis include lifestyle and aging.
Masashi Toyoda, Norihiko Sasaki
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Frontiers in NeuroscienceGanglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GM3SD) causes an absence of GM3 and all downstream biosynthetic derivatives, including all the a-, b-, c-series gangliosides, commonly found ...
Jin-ichi Inokuchi +12 more
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The FEBS Journal, Volume 293, Issue 11, Page 3187-3210, June 2026.The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs +7 more
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Gangliosides activate cultured rat brain microglia.
, 1999 Microglia, brain resident macrophages, are activated in brain injuries and several neurodegenerative diseases. However, microglial activators that are produced in the brain are not yet defined.
Joe, E, Pyo, H, Lee, SH, Jung, S, Jou, I
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Gangliosides enhance M2-polarized macrophage elongation induced by IL-4 and IL-13 [PDF]
Kosin Medical JournalBackground Macrophage polarization plays a crucial role in the immune response, and gangliosides regulate macrophage function. In this study, we investigated the role of gangliosides in modulating macrophage morphology and function in response to M2 ...
Snehal Chandrakant Meshram +5 more
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Journal of the Peripheral Nervous System, Volume 31, Issue 2, June 2026.ABSTRACT Background and Aims Autoimmune nodopathy (AN) is a subtype of antibody‐mediated inflammatory neuropathy targeting the node of Ranvier (NoR). Diagnosis requires detection of anti‐(para)nodal autoantibodies like contactin‐1 and neurofascin‐155 via ELISA or cell‐based assays, but protocols are inconsistent. Causes of node autoimmunity are unknown,
Luise Appeltshauser +9 more
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Analyses of gangliosides by normal-phase LC-MS with regard to the glycan structure of gangliosides.
, 2015 A, Scheme of synthesis pathway of a- and b-series of gangliosides. B, Representative chromatograms of normal-phase LC-MS of gangliosides using an NH2 column.
Akemi Suzuki (142229) +8 more
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Gangliosides and autoimmune peripheral nerve diseases
, 2018 A wide range of neuroimmunological diseases, referred to as autoimmune neuropathies, affect the peripheral nervous systems (PNS). The PNS is structurally diverse with complex anatomical compartments enriched in many different myelin and neuronal ...
Goodfellow, John A. +3 more
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Gangliosides Inhibit Glucosylceramide Synthase: A Possible Role in Ganglioside Therapy [PDF]
, 1991 Gangliosides stimulate the hydrolysis of glucosylceramide (GlcCer), their precursor, and therefore may lower the level of cellular GlcCer and exert a feedback control effect to slow the formation of gangliosides.
Girja S. Shukla +5 more
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, 2018 Gangliosides are classified in 4 series according to the number of sialic acid residues linked to lactosylceramide (LacCer) [22]. The 0-series gangliosides are directly synthesized from LacCer and the precursors of other series are synthesized by ...
Clément P. Delannoy (5146082) +8 more
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