Results 111 to 120 of about 44,745 (260)

Dietary gangliosides rescue GM3 synthase deficiency outcomes in mice accompanied by neurogenesis in the hippocampus

Frontiers in Neuroscience
Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GM3SD) causes an absence of GM3 and all downstream biosynthetic derivatives, including all the a-, b-, c-series gangliosides, commonly found ...
Jin-ichi Inokuchi, Jin-ichi Inokuchi, Shinji Go, Akemi Suzuki, Osamu Nakagawasai, Takayo Odaira-Satoh, Lucas Veillon, Takahiro Nitta, Paul McJarrow, Hirotaka Kanoh, Kei-ichiro Inamori, Koichi Tan-No, Michael Collett   +12 more
doaj   +1 more source

Late‐Onset Tay–Sachs Disease With SMALED‐Like Muscle MRI Pattern Despite a Distinct Clinical Phenotype

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background Late‐onset Tay–Sachs disease (LOTS) is a rare lysosomal disorder that contrasts with the classical infantile form by presenting with milder and heterogeneous neurological manifestations, including lower motor neuron phenotypes.
Rodrigo Siqueira Soares Frezatti, Trajano Aguiar Pires Gonçalves, Manoella Guerra de Albuquerque Bueno, André Clériston José dos Santos, Lindsay A. Wilson, Natalia Dominik, Michael G. Hanna, Jasper Morrow, Alex M. Rossor, Mary M. Reilly, Pedro José Tomaselli, Wilson Marques Junior   +11 more
wiley   +1 more source

Gangliosides and autoimmune diabetes

, 1997
Gangliosides are sialic acid-containing glycolipids which are formed by a hydrophobic portion, the ceramide, and a hydrophilic part, i.e. the oligosaccharide chain. First described in neural tissue, several studies have shown that gangliosides are almost
Farilla L., Misasi R., Dionisi S., Di Mario U., Carabba B., DOTTA, FRANCESCO, Lenti L.   +6 more
core   +1 more source

Characterization of a hamster melanoma-associated ganglioside antigen as 7-O-acetylated disialoganglioside GD3

Journal of Lipid Research, 1993
We previously reported a hamster animal model of melanoma in which the tumor tissue expresses gangliosides GM3, GD3, and O-acetyl GD3. This ganglioside pattern is similar to that in human melanomas (Ren, S., A. Slominski, and R. K. Yu.
S Ren, T Ariga, JN Scarsdale, Y Zhang, A Slominski, PO Livingston, G Ritter, Y Kushi, RK Yu   +8 more
doaj   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

Analyses of gangliosides by normal-phase LC-MS with regard to the glycan structure of gangliosides.

, 2015
A, Scheme of synthesis pathway of a- and b-series of gangliosides. B, Representative chromatograms of normal-phase LC-MS of gangliosides using an NH2 column.
Akemi Suzuki (142229), Hanaki Yasumori (709086), Naoto Oikawa (709083), Katsuhiko Yanagisawa (692095), Teruhiko Matsubara (709084), Ryoto Fukuda (709085), Shigeo Murayama (396047), Toshinori Sato (709087), Hiroyuki Hatsuta (527179)   +8 more
core   +1 more source

High Resolution 3‐T Magnetic Resonance Tractography Cannot Localise Conduction Block in Multifocal Motor Neuropathy With Conduction Block

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims Definite diagnosis of multifocal motor neuropathy with conduction block (MMNCB) requires identification of electrophysiological motor conduction block (CB), which is sometimes challenging to demonstrate. Magnetic resonance (MR) neurography is recommended as a supportive diagnostic criterion.
Ryan Y. S. Keh, Laura Zambreanu, Stephen Wastling, Carolynne M. Doherty, Hamza A. Salhab, Chandrashekar Hoskote, Sachit Shah, Julian Blake, Aisling S. Carr, John Thornton, Jasper M. Morrow, Michael P. Lunn   +11 more
wiley   +1 more source

Gangliosides enhance neurite outgrowth in PC12 cells

, 1983
Gangliosides are surface membrane components that have been suggested to play a significant role in the regulation of many cellular events including neuronal differentiation, growth and regeneration.
G. Ferrari, M. Fabris, A. Gorio
core   +1 more source

Membrane Complexity and Phase Behavior Dictate the Stability of Membrane‐Inserted Aβ42 Hexamers

ChemPhysChem, Volume 27, Issue 16, 27 August 2026.
Neuronal membrane order and the specific interplay of constituent lipids modulate the structural stability of Aβ(1–42) hexamers. This lipid environment facilitates the stabilization of a transmembrane β‐barrel conformation, providing a molecular basis for understanding how membrane composition influences the formation of stable amyloid pores in ...
Bastian Ferdinand Bundschuh, Franziska Kley, Yu Wang, Birgit Strodel   +3 more
wiley   +1 more source

Vascular Diseases and Gangliosides

, 2019
Vascular diseases, such as myocardial infarction and cerebral infarction, are most commonly caused by atherosclerosis, one of the leading causes of death worldwide. Risk factors for atherosclerosis include lifestyle and aging.
Masashi Toyoda, Norihiko Sasaki
core   +1 more source