Results 71 to 80 of about 102,021 (351)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Port Site Hernia after Laparoscopic Surgery: Incidence, Pathogenesis and Management Strategies [PDF]

Journal of Clinical and Diagnostic Research
Although Port Site Hernia (PSH) is a rare complication after laparoscopic surgery, with an incidence of 0.65-2.8%, it can be deadly due to the inherent risk of bowel strangulation. Various factors like trocar size, design, improper closure of the defect,
Vinayak Vishnupant Kshirsagar, Yogesh Bhupal Langade, Prabhat Bhaskarrao Nichkaode, Nilam Sandeep Memane, Rakesh Diliprao Kothavale   +4 more
doaj   +1 more source

Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene

Frontiers in Microbiology, 2019
Clostridium perfringens (C. perfringens) is Gram-positive anaerobic, spore-forming rod-shaped bacterial pathogen that is widely distributed in nature. This bacterium is known as the causative agent of a foodborne illness and of gas gangrene.
K. Yamamura, H. Ashida, Tokuju Okano, Ryo Kinoshita-Daitoku, Shiho Suzuki, K. Ohtani, M. Hamagaki, T. Ikeda, Toshihiko Suzuki   +8 more
semanticscholar   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Fournier’s Gangrene: Clinical Presentation of 13 Cases

Medical Science Monitor, 2018
Background Fournier’s gangrene (FG) is a fulminant form of infective, polymicrobial, necrotizing fasciitis of the perineal, genital, and perianal regions.
B. Kuzaka, M. Wróblewska, T. Borkowski, D. Kawecki, P. Kuzaka, G. Młynarczyk, P. Radziszewski   +6 more
semanticscholar   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Análise dos fatores de risco relacionados às amputações maiores e menores de membros inferiores em hospital terciário

Jornal Vascular Brasileiro
Resumo Contexto As amputações dos membros inferiores, sejam definidas como maiores ou menores, são um grave problema de saúde, com altos índices de morbimortalidade e de relevante impacto social. Diferentes características clínicas dos pacientes parecem
Seleno Glauber de Jesus-Silva, João Pedro de Oliveira, Matheus Henrique Colepicolo Brianezi, Melissa Andreia de Moraes Silva, Arturo Eduardo Krupa, Rodolfo Souza Cardoso   +5 more
doaj   +1 more source

Survival and associated risk factors in patients with diabetes and amputations caused by infectious foot gangrene

Journal of Foot and Ankle Research, 2018
BackgroundInfectious gangrene of the foot is a serious complication of diabetes that usually leads to a certain level of lower-extremity amputation (LEA).
Yu-Yao Huang, Cheng-Wei Lin, Hui-Mei Yang, Shih-Yuan Hung, I-Wen Chen   +4 more
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

A curious case of black limb in tuberculosis

Journal of Global Infectious Diseases
With a global burden of 10 million new cases per year, tuberculosis (TB) is a major health problem in developing countries like India, with an incidence of 2.69 million.
Pournami Balasundaran, Heyma Krishna Manoharan, Jitendra Kishore Bhargava, Veerendra Arya, Gowtham Natarajan   +4 more
doaj   +1 more source