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Characterisation and Hypolipidaemic Effects of Tlayudas, Widely Consumed Tortillas, Containing <i>Ganoderma lucidum</i> Extracts on an In Vivo Model of Hypercholesterolaemia. [PDF]

Int J Food Sci
Preciado Iñiga G, Martínez-Carrera D, Meneses ME, Sánchez M, Argumedo A, Bonilla M, Castillo I, Petlacalco B, Morales A, Fernández N, Martínez W, Antonio-Bautista J, Sánchez-Tapia M, Coutiño-Hernández D, Torres N, Tovar AR, Leal-Lara H.   +16 more
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Ganoderic acid B attenuates LPS-induced lung injury

International Immunopharmacology, 2020
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious respiratory disease, the mechanism is unclear. This paper revealed the mechanism of ganoderic acid B (BB) on lipopolysaccharide-induced pneumonia in mice. Pneumonia model was induced by LPS in mice and A549 cells. Lung dry/wet weight (W/D) and myeloperoxidase (MPO) activity
Jiang, Shi, Huan, Wang, Jumin, Liu, Yang, Zhang, Junfang, Luo, Yan, Li, Chao, Yang, Junguang, Jiang   +7 more
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Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice

Food & Function, 2021
Ganoderic acid, isolated from Ganoderma lucidum, significantly ameliorated 5-FU induced cognitive impairment via preventing mitochondrial impairment and enhancing neuronal survival and growth.
Abudumijiti Abulizi, Jianhua Ran, Yuwei Ye, Yongpan An, Yukun Zhang, Zhizhen Huang, Simei Lin, Hong Zhou, Dongmei Lin, Lianfu Wang, Zhibin Lin, Min Li, Baoxue Yang   +12 more
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Mitochondrial pyruvate carrier influences ganoderic acid biosynthesis in Ganoderma lucidum

Applied Microbiology and Biotechnology, 2023
Mitochondrial pyruvate carriers (MPCs), located in the inner membrane of mitochondria, are essential carriers for pyruvate to enter mitochondria. MPCs regulate a wide range of intracellular metabolic processes, such as glycolysis, the tricarboxylic acid cycle (TCA cycle), fatty acid metabolism, and amino acid metabolism.
Juhong Chen, Wenzhao Xu, Zi Wang, Li Tian, Weidong Liu, Ang Ren, Rui Liu, Jing Zhu, Liang Shi   +8 more
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Biotechnological production and application of ganoderic acids

Applied Microbiology and Biotechnology, 2010
Ganoderic acids (GAs), a kind of highly oxygenated lanostane-type triterpenoids, are important bioactive constituents of the famous medicinal mushroom Ganoderma lucidum. They have received wide attention in recent years due to extraordinarily pharmacological functions. Submerged fermentation of G.
Jun-Wei, Xu, Wei, Zhao, Jian-Jiang, Zhong   +2 more
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Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor

Bioorganic & Medicinal Chemistry Letters, 2009
Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.
Jie, Liu, Jun, Shiono, Kuniyoshi, Shimizu, Akiko, Kukita, Toshio, Kukita, Ryuichiro, Kondo   +5 more
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Ganoderic Acid and Lucidenic Acid (Triterpenoid)

2014
Ganoderma species is known as a functional mushroom used in many Asian countries. Triterpenoids, ganoderic acids, and lucidenic acids have been isolated from Ganoderma species (Ganodermataceae family), such as Ganoderma lucidum. Triterpenoids have been investigated for their biological activities, including antibacterial, antiviral, antitumor ...
Chin-Lin, Hsu, Gow-Chin, Yen
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Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice

Pharmacology, 2020
<b><i>Background:</i></b> To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. <b><i>Methods:</i></b> ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0.
Gaoyan, Wen, Tian, Li, Hua, He, Xianmei, Zhou, Jia, Zhu   +4 more
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A new ganoderic acid from Ganoderma lucidum mycelia

Journal of Asian Natural Products Research, 2010
A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3 ...
Jia-Le, Wang, Ying-Bo, Li, Ru-Ming, Liu, Jian-Jiang, Zhong   +3 more
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Ganoderic acid, lanostanoid triterpene: a key player in apoptosis

Investigational New Drugs, 2017
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis.
Balraj Singh, Gill, , Navgeet, Richa, Mehra, Vicky, Kumar, Sanjeev, Kumar   +4 more
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