A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi [PDF]
Frontiers in Microbiology, 2022 The methyltransferase LaeA is a global regulator involved in the biosynthesis of secondary metabolites by ascomycete fungi. However, little is known of its regulatory role in basidiomycete fungi.
Qin Luo, Na Li, Jun-Wei Xu
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Metabolomic Insights into the Mechanisms of Ganoderic Acid: Protection against α-Amanitin-Induced Liver Injury [PDF]
Metabolites, 2023 α-Amanitin is a representative toxin found in the Amanita genus of mushrooms, and the consumption of mushrooms containing α-Amanitin can lead to severe liver damage.
Chong Zheng +7 more
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Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise-Induced Fatigue via AMPK/PGC-1α Pathway Activation. [PDF]
Food Sci NutrThis study investigated the effects of GAA, an active ingredient in Ganoderma lucidum, on exercise‐induced fatigue. GAA effectively enhances exercise performance by improving endurance duration while simultaneously reducing metabolic byproducts and muscle fiber damage.
Zhu J +8 more
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Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst [PDF]
Metabolites, 2022 Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents. Ganoderic acids are the most abundant triterpenoids that showed pharmacological activity.
Mohd Hafizur Rehman Ansari +4 more
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Putative identification of CASTOR1 as one of the targets of ganoderic acid a via thermal proteome profiling and molecular docking [PDF]
Frontiers in PharmacologyIn traditional Chinese medicine theory, aging is hypothesized to arise from severe deficiency of kidney essence, which is posited to induce “emptiness of the sea of marrow”.
Aifang Chen +4 more
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Characteristics of the Genome, Transcriptome and Ganoderic Acid of the Medicinal Fungus Ganoderma lingzhi [PDF]
Journal of Fungi, 2022 Ganoderma (Ganodermaceae) is a genus of edible and medicinal mushrooms that create a diverse set of bioactive compounds. Ganoderma lingzhi has been famous in China for more than 2000 years for its medicinal properties.
Qiang Wu +7 more
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Cross Talk between GlAQP and NOX Modulates the Effects of ROS Balance on Ganoderic Acid Biosynthesis of Ganoderma lucidum under Water Stress [PDF]
Microbiology Spectrum, 2022 Water stress affects both the growth and development of filamentous fungi; however, the mechanisms underlying their response to water stress remain unclear.
Quanyu Zhu +8 more
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Blue Light Receptor WC-2 Regulates Ganoderic Acid Biosynthesis in Ganoderma lingzhi [PDF]
Journal of FungiGanoderic acid (GA) is a key bioactive component with pharmacological properties that is found in Ganoderma lingzhi, a renowned medicinal mushroom. Currently, the regulatory mechanisms underlying GA biosynthesis in G.
Yan Xu +5 more
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ExplorationNeuroinflammation plays a critical role in cerebral ischemic injury, making it an important therapeutic target for stroke treatment. Ganoderic acids (GAs), the primary bioactive compounds isolated from Ganoderma lucidum, exhibit well‐demonstrated anti ...
Ang Ma +17 more
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The Efficacy & Molecular Mechanisms of a Terpenoid Compound Ganoderic Acid C1 on Corticosteroid-Resistant Neutrophilic Airway Inflammation: In vivo and in vitro Validation [PDF]
Journal of Inflammation ResearchZhen-Zhen Wang,1– 3,* Hang Li,4,* Anish R Maskey,2,* Kamal Srivastava,2,5,* Changda Liu,6,* Nan Yang,2,5 Taoyun Xie,7 Ziyi Fu,8 Junxiong Li,9 Xiaohong Liu,10 Hugh A Sampson,6 Xiu-Min Li2,11 1Academy of Chinese Medical Science, Henan ...
Wang ZZ +11 more
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