A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi [PDF]
Frontiers in Microbiology, 2022 The methyltransferase LaeA is a global regulator involved in the biosynthesis of secondary metabolites by ascomycete fungi. However, little is known of its regulatory role in basidiomycete fungi.
Qin Luo, Na Li, Jun-Wei Xu
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Metabolomic Insights into the Mechanisms of Ganoderic Acid: Protection against α-Amanitin-Induced Liver Injury [PDF]
Metabolites, 2023 α-Amanitin is a representative toxin found in the Amanita genus of mushrooms, and the consumption of mushrooms containing α-Amanitin can lead to severe liver damage.
Chong Zheng +7 more
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Quality Difference Study of 6 Varieties of Ganoderma Lucidum with Different Origins [PDF]
Frontiers in Pharmacology, 2012 The quality difference of 6 varieties Ganoderma Lucidum with different origins was investigated in this study by comparing the contents of ganoderic acid A and B, polysaccharide and triterpenoids .The contents of ganoderic acid A and B in G.lucidum were ...
Juan eLu +5 more
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Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise-Induced Fatigue via AMPK/PGC-1α Pathway Activation. [PDF]
Food Sci NutrThis study investigated the effects of GAA, an active ingredient in Ganoderma lucidum, on exercise‐induced fatigue. GAA effectively enhances exercise performance by improving endurance duration while simultaneously reducing metabolic byproducts and muscle fiber damage.
Zhu J +8 more
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Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst [PDF]
Metabolites, 2022 Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents. Ganoderic acids are the most abundant triterpenoids that showed pharmacological activity.
Mohd Hafizur Rehman Ansari +4 more
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Characteristics of the Genome, Transcriptome and Ganoderic Acid of the Medicinal Fungus Ganoderma lingzhi [PDF]
Journal of Fungi, 2022 Ganoderma (Ganodermaceae) is a genus of edible and medicinal mushrooms that create a diverse set of bioactive compounds. Ganoderma lingzhi has been famous in China for more than 2000 years for its medicinal properties.
Qiang Wu +7 more
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Synergistic Effect of Elicitors in Enhancement of Ganoderic Acid Production: Optimization and Gene Expression Studies [PDF]
Applied Food Biotechnology, 2015 Ganoderma lucidum is one of the most well-known fungi, and has many applications in medicine. Ganoderic acid is among the valuable secondary metabolites of Ganoderma lucidum, and responsible for the inhibition of the tumor cell growth and cancer ...
Motaharehsadat Heydarian +4 more
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Putative identification of CASTOR1 as one of the targets of ganoderic acid a via thermal proteome profiling and molecular docking [PDF]
Frontiers in PharmacologyIn traditional Chinese medicine theory, aging is hypothesized to arise from severe deficiency of kidney essence, which is posited to induce “emptiness of the sea of marrow”.
Aifang Chen +4 more
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Impact of Rifampin Induction on the Fermentation Production of Ganoderic Acids by Medicinal Mushroom Ganoderma lucidum [PDF]
Applied Food Biotechnology, 2016 Backgrounds and Objectives: Ganoderic acids are the most valuable secondary metabolites in Ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. However, application of ganoderic acids is limited due to
Fahimeh Nojoki +6 more
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Cross Talk between GlAQP and NOX Modulates the Effects of ROS Balance on Ganoderic Acid Biosynthesis of Ganoderma lucidum under Water Stress [PDF]
Microbiology Spectrum, 2022 Water stress affects both the growth and development of filamentous fungi; however, the mechanisms underlying their response to water stress remain unclear.
Quanyu Zhu +8 more
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